| Long name: |
NET1 Primary Polyclonal Antibody |
| Also known as: |
NET1 PAb |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
NET1 |
| Specificity: |
This is a highly specific antibody against NET1 |
| Modification(s): |
None |
| Modification site(s): |
Unmodified antibody |
| Clonality: |
Polyclonal antibody |
| Clone number: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human NET1 |
| Gene ID number: |
10276 |
| Tested Applications: |
IF(IHC-P), IHC-P, WB |
| Recommended dilutions: |
IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity: |
Mouse, Rat, Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
At least 13 genetic variations have been reported in the noradrenaline transporter protein that affect noradrenaline re-uptake and concentrations in cerebrospinal fluid in humans, In rat brain, In the CNS, Na+/Cl- dependent transport process mediated by noradrenaline transporters, Noradrenaline is released from the post ganglionic sympathetic nerve endings and exerts its effects locally in the immediate vicinity of its release, Noradrenaline released from pre-synaptic nerve terminals is reabsorbed (70-90%) by noradrenaline transporters and its biological effects are terminated, Noradrenaline transporters constitute the primary mechanism for inactivation of synaptically released noradrenaline, Peripherally, Recently, The association between these genetic variations in noradrenaline transporters and several psychiatric and cardiovascular disorders is just emerging, The noradrenaline transport via noradrenaline transporters is an active, a single amino acid mutation (hNET-A457P) showed deficiency in noradrenaline transport in an orthostatic intolerance patient, a term used for the hormone adrenaline and its sequentially hydroxylated form noradrenaline, alertness and arousal, and are deficient in affective and autonomic disorders, and control of the endocrine and autonomic nervous systems, and hippocampus and cortex, are targets for multiple antidepressants and psychostimulants, axons and dendrites, both cognitive and non-cognitive expression of behaviors, but is absent from epinephrine- and dopamine-containing neurons, is involved in fight or flight responses, noradrenaline is involved in a number of physiological responses including mood, noradrenaline is present in sympathetic nerve endings and has full control of the sympathetic nervous system, noradrenaline transporter is expressed in noradrenergic neuronal somata, sleep regulation, Catecholamine |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
NET, NET, NET1, Norepinephrine transporter, SLC6A2, SLC6A5, SLC6A5, Sodium dependent noradrenaline transporter, Solute carrier family 6 member 2, Solute carrier family 6 member 2, Solute carrier family 6 neurotransmitter transporter norepinephrine member 5, NAT1 |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
NET1 |
| Short name: |
NET1 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
neuroepithelial cell transforming 1 (Antibody to) |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
ARHGEF8 and NET1A, GTP-Rho binding, NET1 and IDBG-48898 and ENSG00000173848 and 10276, NET1 and IDBG-639242 and ENSBTAG00000007648 and 507365, Net1 and IDBG-128472 and ENSMUSG00000021215 and 56349, nuclei, this GO :0001558 and regulation of cell growth and biological process this GO :0005085 and guanyl-nucleotide exchange factor activity and molecular function this GO :0005089 and Rho guanyl-nucleotide exchange factor activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005829 and cytosol and cellular component this GO :0005886 and plasma membrane and cellular component this GO :0007165 and signal transduction and biological process this GO :0007264 and small GTPase mediated signal transduction and biological process this GO :0017049 and GTP-Rho binding and molecular function this GO :0032321 and positive regulation of Rho GTPase activity and biological process this GO :0035023 and regulation of Rho protein signal transduction and biological process this GO :0035556 and intracellular signal transduction and biological process this GO :0043065 and positive regulation of apoptotic process and biological process this GO :0048011 and neurotrophin TRK receptor signaling pathway and biological process this GO :0051056 and regulation of small GTPase mediated signal transduction and biological process this GO :0051451 and myoblast migration and biological process this GO :0070301 and cellular response to hydrogen peroxide and biological process this GO :0071479 and cellular response to ionizing radiation and biological process this GO :0097190 and apoptotic signaling pathway and biological process this GO :1900026 and positive regulation of substrate adhesion-dependent cell spreading and biological process, this GO :0005085 : guanyl-nucleotide exchange factor activity, this GO :0005085 : guanyl-nucleotide exchange factor activity and also this GO :0005089 : Rho guanyl-nucleotide exchange factor activity and also this GO :0005515 : protein binding and also this GO :0017049 : GTP-Rho binding, this GO :0005089 : Rho guanyl-nucleotide exchange factor activity, this GO :0005515 : protein binding, this GO :0017049 : GTP-Rho binding, neuroepithelial cell transforming 1 |
| Identity: |
14592 |
| Gene: |
NET1 |
More about : NET1 |
| Long gene name: |
neuroepithelial cell transforming 1 |
| Synonyms: |
ARHGEF8 NET1A |
| Locus: |
10p15, 1 |
| Discovery year: |
2001-02-08 |
| GenBank acession: |
AJ010046 |
| Entrez gene record: |
10276 |
| Pubmed identfication: |
8649828 |
| RefSeq identity: |
NM_005863 |
| Classification: |
Rho guanine nucleotide exchange factors Pleckstrin homology domain containing |
| Havana BLAST/BLAT: |
OTTHUMG00000017596 |