| Long name: |
VAV2 Primary Polyclonal Antibody |
| Also known as: |
VAV2 PAb |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
VAV2 |
| Specificity: |
This is a highly specific antibody against VAV2 |
| Modification(s): |
None |
| Modification site(s): |
Unmodified antibody |
| Clonality: |
Polyclonal antibody |
| Clone number: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human VAV2 |
| Gene ID number: |
7410 |
| Tested Applications: |
IF(IHC-P), IHC-P, WB |
| Recommended dilutions: |
IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity: |
Mouse, Rat, Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
Both proteins are comprised of a Dbl homology (DH) domain with guanosine nucleotide exchange (GEF) activity exclusively directed towards Rho/Rac GTPases, Constitutive expression of a VAV2 oncoprotein may result in morphological alterations including highly enlarged cells in which karyokinesis and cytokinesis frequently are uncoupled, GEF activity of RhoA family G proteins is induced by tyrosine phosphorylation in wild type VAV2, a calponin-homology (CH) region, a pleckstrin homology (PH) domain, an acidic domain (AD) a zinc finger butterfly motif, and is constitutively activated in N terminus deleted oncogene forms, two SH3 regions and one SH2 domain, VAV2 is a ubiquitously expressed structural homolog of the VAV protooncogene that is expressed preferentially in hematopoetic cells |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
Protein vav 2, VAV 2, VAV2 oncogene, VAV2_HUMAN, Vav 2 oncogene, Oncogene VAV2 |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
VAV2 |
| Short name: |
VAV2 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
vav 2 guanine nucleotide exchange factor (Antibody to) |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
Plasma membranes, VAV-2, VAV2 and IDBG-640833 and ENSBTAG00000004511 and 515718, VAV2 and IDBG-91583 and ENSG00000160293 and 7410, Vav2 and IDBG-151026 and ENSMUSG00000009621 and 22325, metal ion binding, this GO :0001525 and angiogenesis and biological process this GO :0005085 and guanyl-nucleotide exchange factor activity and molecular function this GO :0005089 and Rho guanyl-nucleotide exchange factor activity and molecular function this GO :0005154 and epidermal growth factor receptor binding and molecular function this GO :0005515 and protein binding and molecular function this GO :0005737 and cytoplasm and cellular component this GO :0005829 and cytosol and cellular component this GO :0005886 and plasma membrane and cellular component this GO :0007165 and signal transduction and biological process this GO :0007264 and small GTPase mediated signal transduction and biological process this GO :0007411 and axon guidance and biological process this GO :0007596 and blood coagulation and biological process this GO :0010468 and regulation of gene expression and biological process this GO :0016477 and cell migration and biological process this GO :0030031 and cell projection assembly and biological process this GO :0030032 and lamellipodium assembly and biological process this GO :0030168 and platelet activation and biological process this GO :0030193 and regulation of blood coagulation and biological process this GO :0032321 and positive regulation of Rho GTPase activity and biological process this GO :0035023 and regulation of Rho protein signal transduction and biological process this GO :0035556 and intracellular signal transduction and biological process this GO :0038095 and Fc-epsilon receptor signaling pathway and biological process this GO :0038096 and Fc-gamma receptor signaling pathway involved in pha this GO cytosis and biological process this GO :0043065 and positive regulation of apoptotic process and biological process this GO :0043087 and regulation of GTPase activity and biological process this GO :0043547 and positive regulation of GTPase activity and biological process this GO :0043552 and positive regulation of phosphatidylinositol 3-kinase activity and biological process this GO :0045087 and innate immune response and biological process this GO :0046872 and metal ion binding and molecular function this GO :0048011 and neurotrophin TRK receptor signaling pathway and biological process this GO :0051056 and regulation of small GTPase mediated signal transduction and biological process this GO :0097190 and apoptotic signaling pathway and biological process, this GO :0005085 : guanyl-nucleotide exchange factor activity, this GO :0005085 : guanyl-nucleotide exchange factor activity and also this GO :0005089 : Rho guanyl-nucleotide exchange factor activity and also this GO :0005154 : epidermal growth factor receptor binding and also this GO :0005515 : protein binding and also this GO :0046872 : metal ion binding, this GO :0005089 : Rho guanyl-nucleotide exchange factor activity, this GO :0005154 : epidermal growth factor receptor binding, this GO :0005515 : protein binding, this GO :0046872 : metal ion binding, vav 2 guanine nucleotide exchange factor |
| Identity: |
12658 |
| Gene: |
VAV2 |
More about : VAV2 |
| Long gene name: |
vav guanine nucleotide exchange factor 2 |
| Synonyms gene name: |
vav 2 oncogene vav 2 guanine nucleotide exchange factor |
| Locus: |
9q34, 2 |
| Discovery year: |
1994-07-15 |
| Entrez gene record: |
7410 |
| Pubmed identfication: |
7762982 |
| Classification: |
Rho guanine nucleotide exchange factors Pleckstrin homology domain containing SH2 domain containing |
| Havana BLAST/BLAT: |
OTTHUMG00000020882 |