| Long name: |
PRMT6 Primary Polyclonal Antibody |
| Also known as: |
PRMT6 PAb |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
PRMT6 |
| Specificity: |
This is a highly specific antibody against PRMT6 |
| Modification(s): |
None |
| Modification site(s): |
Unmodified antibody |
| Clonality: |
Polyclonal antibody |
| Clone number: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen range: |
330-375/375 |
| Subcellular location: |
Nucleus |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human PRMT6 |
| Gene ID number: |
55170 |
| Swiss Prot: |
Q96LA8 |
| Tested Applications: |
IF(IHC-P), IHC-P, WB |
| Recommended dilutions: |
IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity: |
Mouse, Rat, Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
Acts as a regulator of DNA base excision during DNA repair by mediating the methylation of DNA polymerase beta (POLB), Acts as a transcriptional coactivator of a number of steroid hormone receptors including ESR1, Acts as a transcriptional repressor of various genes such as HOXA2, Also methylates histone H2A and H4 'Arg-3' (H2AR3me and H4R3me, ESR2, H3R2me2a represents a specific tag for epigenetic transcriptional repression and is mutually exclusive with methylation on histone H3 'Lys-4' (H3K4me2 and H3K4me3), May play a role in innate immunity against HIV-1 in case of infection by methylating and impairing the function of various HIV-1 proteins such as Tat, Methylates HMGA1, PGR and NR3C1, Preferentially methylates arginyl residues present in a glycine and arginine-rich domain and displays preference for monomethylated substrates, Promotes fasting-induced transcriptional activation of the gluconeogenic program through methylation of the CRTC2 transcription coactivator, Regulates alternative splicing events, Repression of TP53 blocks cellular senescence (By similarity), Rev and Nucleocapsid protein p7 (NC), Specifically mediates the asymmetric dimethylation of histone H3 'Arg-2' to form H3R2me2a, THBS1 and TP53, leading to the stimulation of its polymerase activity by enhancing DNA binding and processivity, respectively), with a strong preference for the formation of aDMA, Arginine methyltransferase that can catalyze the formation of both omega-N monomethylarginine (MMA) and asymmetrical dimethylarginine (aDMA) |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
Heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 6, Histone-arginine N-methyltransferase PRMT6, PRMT6, Protein arginine N-methyltransferase 6, HRMT1L6 |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
PRMT6 |
| Short name: |
PRMT6 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
PRMT6 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
18241 |
| Gene: |
PRMT6 |
More about : PRMT6 |
| Long gene name: |
protein arginine methyltransferase 6 |
| Synonyms gene: |
HRMT1L6 |
| Synonyms gene name: |
HMT1 hnRNP methyltransferase-like 6 (S, cerevisiae) |
| Synonyms: |
FLJ10559 |
| Locus: |
1p13, 3 |
| Discovery year: |
2004-06-22 |
| GenBank acession: |
AK001421 |
| Entrez gene record: |
55170 |
| Pubmed identfication: |
11724789 |
| RefSeq identity: |
NM_018137 |
| Classification: |
Protein arginine methyltransferases |
| Havana BLAST/BLAT: |
OTTHUMG00000010964 |