| Long name: |
ALEXA FLUOR 647 Conjugated, ACVRL1 Polyclonal Antibody |
| Also known as: |
Anti-ACVRL1 PAb ALEXA FLUOR 647 |
| Category: |
Conjugated Primary Antibodies |
| Conjugated with: |
647, ALEXA FLUOR® |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
ACVRL1 |
| Specificity: |
This is a highly specific antibody against ACVRL1 |
| Modification: |
Unmodified |
| Modification Site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen range: |
30-80/503 |
| Subcellular location: |
Extracellular |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human ALK1 |
| Gene ID Number: |
94 |
| Swiss Prot: |
P37023 |
| Tested applications: |
IF(IHC-P) |
| Recommended dilutions: |
IF(IHC-P)(1:50-200) |
| Crossreactivity: |
Mouse, Rat, Human |
| Cross-reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the antigen: |
May bind activin as well, On ligand binding, Type II receptors phosphorylate and activate type I receptors which autophosphorylate, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases, then bind and activate SMAD transcriptional regulators, Type I receptor for TGF-beta family ligands BMP9/GDF2 and BMP10 and important regulator of normal blood vessel development |
| Purification: |
Purified by Protein A |
| Storage conditions: |
50% glycerol and 0, Keep refrigerated at 2 to 8 degrees Celcius for up to one year, 09% sodium azide, Store this antibody in aqueous buffered solution containing 1% BSA |
| Excitation emission: |
650nm/665nm |
| Synonyms: |
HHT2 ALK1 HHT |
| Properties: |
ALEXA FLUOR made this Alexa Fluor 633 conjugate that can be used in multi-color flow cytometry with instruments equipped with a second red laser or red diode, ALEXA FLUOR they should be stored frozen at - 24°, Alexa Fluor 633 is a practical alternative to APC as well as Cy5, Bioss Primary Conjugated Antibodies, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies, It is detected in the FL4 detector of the core's upgraded 2-laser FACScans, Like other Alexa Fluor dyes, exhibits uncommon photo stability, making it an ideal choice for fluorescent microscopy, the ACVRL1 Antibody, C, C for long term storage and for short term at + 5°, For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
ALEXA FLUOR 647, Alexa Fluor |
| Gene target: |
ACVRL1 |
| Short name: |
ACVRL1 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Label: |
ALEXA FLUOR 647 |
| Alternative name: |
ALEXA FLUOR 647, activin A receptor classification II-like 1 (Antibody to) |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
ACVRL1 and IDBG-33826 and ENSG00000139567 and 102723650, ACVRLK1 and ALK-1 and ALK1 and HHT and HHT2 and ORW2 and SKR3 and TSR-I, Acvrl1 and IDBG-185502 and ENSMUSG00000000530 and 11482, BT, Cell surfaces, DNA-templated and biological process this GO :0006468 and protein phosphorylation and biological process this GO :0007162 and negative regulation of cell adhesion and biological process this GO :0007165 and signal transduction and biological process this GO :0007178 and transmembrane receptor protein serine/threonine kinase signaling pathway and biological process this GO :0007179 and transforming growth factor beta receptor signaling pathway and biological process this GO :0008015 and blood circulation and biological process this GO :0008217 and regulation of blood pressure and biological process this GO :0008285 and negative regulation of cell proliferation and biological process this GO :0009986 and cell surface and cellular component this GO :0010596 and negative regulation of endothelial cell migration and biological process this GO :0010862 and positive regulation of pathway-restricted SMAD protein phosphorylation and biological process this GO :0016020 and membrane and cellular component this GO :0016021 and integral component of membrane and cellular component this GO :0016361 and activin receptor activity, DNA-templated and biological process this GO :0045944 and positive regulation of transcription from RNA polymerase II promoter and biological process this GO :0046332 and SMAD binding and molecular function this GO :0046872 and metal ion binding and molecular function this GO :0048185 and activin binding and molecular function this GO :0048514 and blood vessel morphogenesis and biological process this GO :0050431 and transforming growth factor beta binding and molecular function this GO :0051291 and protein heterooli this GO merization and biological process this GO :0051895 and negative regulation of focal adhesion assembly and biological process this GO :0060836 and lymphatic endothelial cell differentiation and biological process this GO :0060840 and artery development and biological process this GO :0060841 and venous blood vessel development and biological process this GO :0061154 and endothelial tube morphogenesis and biological process this GO :0061298 and retina vasculature development in camera-type eye and biological process this GO :0071560 and cellular response to transforming growth factor beta stimulus and biological process this GO :0071773 and cellular response to BMP stimulus and biological process this GO :2000279 and negative regulation of DNA biosynthetic process and biological process, spreading of epidermal cells and biological process this GO :0043025 and neuronal cell body and cellular component this GO :0043535 and regulation of blood vessel endothelial cell migration and biological process this GO :0043537 and negative regulation of blood vessel endothelial cell migration and biological process this GO :0045602 and negative regulation of endothelial cell differentiation and biological process this GO :0045603 and positive regulation of endothelial cell differentiation and biological process this GO :0045766 and positive regulation of angiogenesis and biological process this GO :0045893 and positive regulation of transcription, this GO :0001525 and angiogenesis and biological process this GO :0001701 and in utero embryonic development and biological process this GO :0001936 and regulation of endothelial cell proliferation and biological process this GO :0001937 and negative regulation of endothelial cell proliferation and biological process this GO :0001938 and positive regulation of endothelial cell proliferation and biological process this GO :0001946 and lymphangiogenesis and biological process this GO :0001955 and blood vessel maturation and biological process this GO :0001974 and blood vessel remodeling and biological process this GO :0002043 and blood vessel endothelial cell proliferation involved in sprouting angiogenesis and biological process this GO :0004672 and protein kinase activity and molecular function this GO :0004674 and protein serine/threonine kinase activity and molecular function this GO :0004675 and transmembrane receptor protein serine/threonine kinase activity and molecular function this GO :0004702 and receptor signaling protein serine/threonine kinase activity and molecular function this GO :0004713 and protein tyrosine kinase activity and molecular function this GO :0005024 and transforming growth factor beta-activated receptor activity and molecular function this GO :0005025 and transforming growth factor beta receptor activity, this GO :0004672 : protein kinase activity, this GO :0004672 : protein kinase activity and also this GO :0004674 : protein serine/threonine kinase activity and also this GO :0004675 : transmembrane receptor protein serine/threonine kinase activity and also this GO :0004702 : receptor signaling protein serine/threonine kinase activity and also this GO :0004713 : protein tyrosine kinase activity and also this GO :0005024 : transforming growth factor beta-activated receptor activity and also this GO :0005025 : transforming growth factor beta receptor activity, this GO :0004674 : protein serine/threonine kinase activity, this GO :0004675 : transmembrane receptor protein serine/threonine kinase activity, this GO :0004702 : receptor signaling protein serine/threonine kinase activity, this GO :0004713 : protein tyrosine kinase activity, this GO :0005024 : transforming growth factor beta-activated receptor activity, this GO :0005025 : transforming growth factor beta receptor activity, this GO :0005515 : protein binding, this GO :0005524 : ATP binding, this GO :0016361 : activin receptor activity, this GO :0016772 : transferase activity, this GO :0019901 : protein kinase binding, this GO :0046332 : SMAD binding, this GO :0046872 : metal ion binding, this GO :0048185 : activin binding, this GO :0050431 : transforming growth factor beta binding, transferring phosphorus-containing groups, transferring phosphorus-containing groups and also this GO :0019901 : protein kinase binding and also this GO :0046332 : SMAD binding and also this GO :0046872 : metal ion binding and also this GO :0048185 : activin binding and also this GO :0050431 : transforming growth factor beta binding, transferring phosphorus-containing groups and molecular function this GO :0019901 and protein kinase binding and molecular function this GO :0023014 and signal transduction by phosphorylation and biological process this GO :0030308 and negative regulation of cell growth and biological process this GO :0030336 and negative regulation of cell migration and biological process this GO :0030425 and dendrite and cellular component this GO :0030509 and BMP signaling pathway and biological process this GO :0030513 and positive regulation of BMP signaling pathway and biological process this GO :0032332 and positive regulation of chondrocyte differentiation and biological process this GO :0032924 and activin receptor signaling pathway and biological process this GO :0035313 and wound healing, transforming growth factor beta receptor activity, type I, type I, type I and also this GO :0005515 : protein binding and also this GO :0005524 : ATP binding and also this GO :0016361 : activin receptor activity, type I and also this GO :0016772 : transferase activity, type I and molecular function this GO :0005515 and protein binding and molecular function this GO :0005524 and ATP binding and molecular function this GO :0005887 and integral component of plasma membrane and cellular component this GO :0006275 and regulation of DNA replication and biological process this GO :0006355 and regulation of transcription, type I and molecular function this GO :0016772 and transferase activity, 28710 and IDBG-632173 and ENSBTAG00000013843 and 534536, 94, activin A receptor type II-like 1 |
| Identity: |
175 |
| Gene: |
ACVRL1 |
More about : ACVRL1 |
| Long gene name: |
activin A receptor like type 1 |
| Synonyms gene: |
ACVRLK1 ORW2 |
| Synonyms gene name: |
activin A receptor type II-like 1 activin A receptor type IL |
| Locus: |
12q13, 13 |
| Discovery year: |
1994-12-12 |
| GenBank acession: |
L17075 |
| Entrez gene record: |
94 |
| Pubmed identfication: |
8397373 8640225 22718755 |
| RefSeq identity: |
NM_000020 |
| Classification: |
Type 1 receptor serine/threonine kinases |
| Havana BLAST/BLAT: |
OTTHUMG00000169507 |
| Locus Specific Databases: |
Hereditary Hemorrhagic Telangiectasia (HHT) Mutation Database LRG_543 |