| Long name: |
Biotin Conjugated, SIRT7 Polyclonal Antibody |
| Category: |
Conjugated Primary Antibodies |
| Conjugation: |
Biotinylated |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
SIRT7 |
| Specificity: |
This is a highly specific antibody against SIRT7 |
| Modification: |
Unmodified |
| Modification site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen_range: |
250-300/400 |
| Subcellular location: |
Nucleus, Cytoplasm |
| Source: |
KLH conjugated synthetic peptide derived from human SIRT7 |
| Gene ID number: |
51547 |
| Swiss Prot: |
Q9NRC8 |
| Tested applications: |
IHC-F, IHC-P, WB |
| Recommended dilutions: |
IHC-F(1:100-500), IHC-P(1:100-500), WB(1:100-1000) |
| Crossreactivity: |
Mouse, Rat, Human |
| Crossreactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Antigen background: |
Also required to restore the transcription of ribosomal RNA (rRNA) at the exit from mitosis: promotes the association of RNA polymerase I with the rDNA promoter region and coding region, H3K18 hypoacetylation has been reported as a marker of malignancy in various cancers and seems to maintain the transformed phenotype of cancer cells, H3K18Ac, H3K18Ac is mainly present around the transcription start site of genes and has been linked to activation of nuclear hormone receptors, In contrast to other histone deacetylases, May also deacetylate p53/TP53 and promotes cell survival, Moreover, SIRT7 thereby acts as a transcription repressor, Stimulates transcription activity of the RNA polymerase I complex, These data suggest that SIRT7 may play a key role in oncogenic transformation by suppresses expression of tumor suppressor genes by locus-specific deacetylation of H3K18Ac at promoter regions, directly linked to control of gene expression, displays selectivity for a single histone mark, however such data need additional confirmation, NAD-dependent protein deacetylase that specifically mediates deacetylation of histone H3 at 'Lys-18' (H3K18Ac) |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA |
| Properties: |
Avidin and Streptavidin bind to the small biotin and are couple to HRP or AP for ELISA, Biotin conjugates can be detected by horseradish peroxidase, To break the streptavidin Biotin bond we suggest to use a 6 molar guanidine HCl solution with acidity of pH 1, alkaline phosphatase substrates or anti biotin conjugated antibodies, 6, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
SIRT7 Conjugated |
| Short name: |
Conjugated, SIRT7 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, antibody Conjugates, Antibody |
| Label: |
Biotin |
| Alternative name: |
biotinilated coupled, SIRT7 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
14935 |
| Gene: |
SIRT7 |
More about : SIRT7 |
| Long gene name: |
sirtuin 7 |
| Synonyms gene name: |
S, cerevisiae) , homolog) 7 sirtuin (silent mating type information regulation 2 homolog) 7 (S, sirtuin (silent mating type information regulation 2, cerevisiae |
| Locus: |
17q25, 3 |
| Discovery year: |
2001-03-20 |
| GenBank acession: |
AF233395 |
| Entrez gene record: |
51547 |
| Pubmed identfication: |
10873683 16618798 |
| RefSeq identity: |
NM_016538 |
| Classification: |
Sirtuins |
| Havana BLAST/BLAT: |
OTTHUMG00000177957 |