NFKB p65(Thr254) Antibody, Cy7 Conjugated

Catalog number:	bs-5662R-Cy7 Buy Now
Price:	333 €
Supplier:	Bioss Primary Conjugated Antibodies
Product name:	NFKB p65(Thr254) Antibody, Cy7 Conjugated
Quantity:	0.1ml
Related search:	nfkappab antibody complex factor the complexes

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Long name:	Cy7 Conjugated, NFKB p65(Thr254) Polyclonal Antibody
Category:	Conjugated Primary Antibodies
Conjugation:	Cy7
Host Organism:	Rabbit (Oryctolagus cuniculus)
Target Antigen:	NFKB p65 Thr254
Specificity:	This is a highly specific antibody against NFKB p65 Thr254
Modification:	Phosphorylation
Modification site:	Thr254
Clonality:	Polyclonal
Clone:	Polyclonal antibody
Concentration:	1ug per 1ul
Immunogen_range:	246-257/551
Subcellular location:	Nucleus, Cytoplasm
Source:	KLH conjugated synthetic phosphopeptide derived from human NFKBp65 around the phosphorylation site of Thr254
Gene ID number:	5970
Swiss Prot:	Q04206
Tested applications:	IF(IHC-P)
Recommended dilutions:	IF(IHC-P)(1:50-200)
Crossreactivity:	Mouse, Rat, Human
Crossreactive species details:	not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Antigen background:	Associates with chromatin at the NF-kappa-B promoter region via association with DDX1, Different dimer combinations act as transcriptional activators or repressors, Essential for cytokine gene expression in T-cells (PubMed:15790681), I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, In a conventional activation pathway, NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family, NF-kappa-B heterodimeric p65-p50 and p65-c-Rel complexes are transcriptional activators, NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one, RELB, The NF-kappa-B p65-p65 complex appears to be involved in invasin-mediated activation of IL-8 expression, The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity, The inhibitory effect of I-kappa-B upon NF-kappa-B the cytoplasm is exerted primarily through the interaction with p65, cell growth, differentiation, immunity, p65 shows a weak DNA-binding site which could contribute directly to DNA binding in the NF-kappa-B complex, respectively, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus, tumorigenesis and apoptosis, NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation
Purification method:	This antibody was purified via Protein A
Storage conditions:	50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA
Excitation Emission:	743nm/767nm
Synonyms:	NFKB3, Nuclear factor NF-kappa-B p65 subunit, Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, RELA, Transcription factor p65, p65
Properties:	C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°
Conjugated:	These antibodies are excite for emission at 650 nm and detected at a 676 nm wavelengths
Gene target:	NFKB p65(Thr254) Conjugated
Short name:	Conjugated, NFKB p65(Thr254) Antibody
Technique:	antibodies against human proteins, antibodies for, antibody Conjugates, Antibody
Label:	Cy7
Alternative name:	cyanine 7 coupled, NFKB p65(Thr254) (Antibody to)
Alternative technique:	antibodies

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