Smad3 (Ser425) Antibody

Catalog number:	bs-5616R Buy Now
Price:	368 €
Supplier:	Bioss Primary Conjugated Antibodies
Product name:	Smad3 (Ser425) Antibody
Quantity:	0.1ml
Related search:	smad antibody antibodies primary homolog family

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Long name:	Smad3 (Ser425) Primary Polyclonal Antibody
Also known as:	Smad3 (Ser425) PAb
Category:	Primary Antibodies
Conjugation:	Unconjugated
Target Antigen:	Smad3 Ser425
Specificity:	This is a highly specific antibody against Smad3 Ser425
Modification(s):	Phosphorylation
Modification site(s):	Ser425
Clonality:	Polyclonal antibody
Clone number:	Polyclonal antibody
Concentration:	1ug per 1ul
Immunogen range:	410-425/425
Subcellular location:	Nucleus, Cytoplasm
Source:	KLH conjugated synthetic phosphopeptide derived from human Smad3 around the phosphorylation site of Ser425 [SV(p-S)]
Gene ID number:	4088
Swiss Prot:	P84022
Tested Applications:	IF(IHC-P), IHC-P, WB
Recommended dilutions:	IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000)
Cross reactivity:	Mouse, Rat, Human
Cross reactive species details:	not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen:	Also can form a SMAD3/SMAD4/JUN/FOS complex at the AP-1/SMAD site to regulate TGF-beta-mediated transcription, Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, Has an inhibitory effect on wound healing probably by modulating both growth and migration of primary keratinocytes and by altering the TGF-mediated chemotaxis of monocytes, Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator, Regulator of chondrogenesis and osteogenesis and inhibits early healing of bone fractures, This effect on wound healing appears to be hormone-sensitive, activates transcription, on formation of the SMAD3/SMAD4 complex, Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases
Purification method:	This antibody was purified via Protein A
Storage conditions:	50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names:	HSPC193, HsT17436, JV15-2, LDS1C, MAD homolog 3, MADH3, Mad3, Mothers against DPP homolog 3, Mothers against decapentaplegic homolog 3, SMAD 3, SMAD family member 3, Smad3, hMAD-3, hSMAD3, LDS3
Properties:	C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
Gene target:	Smad3 (Ser425)
Short name:	Smad3 (Ser425) Antibody
Technique:	antibodies against human proteins, antibodies for, Antibody
Alternative name:	SMAD family member 3 (Ser425) (Antibody to)
Alternative technique:	antibodies

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