CHK2 (Thr387) Antibody, Cy3 Conjugated

Catalog number:	bs-5275R-Cy3 Buy Now
Price:	350 €
Supplier:	Bioss Primary Conjugated Antibodies.
Product name:	CHK2 (Thr387) Antibody, Cy3 Conjugated
Quantity:	100ul
Related search:	chk thr antibody antibodies gene ser kinase checkpoint synonyms activation

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Long name:	Cy3 Conjugated, CHK2 (Thr387) Polyclonal Antibody
Category:	Conjugated Primary Antibodies
Conjugation:	cy3 conjugation kit
Host Organism:	Rabbit (Oryctolagus cuniculus)
Target Antigen:	CHK2 Thr387
Specificity:	This is a highly specific antibody against CHK2 Thr387
Modification:	Phosphorylation
Modification site:	Thr387
Clonality:	Polyclonal
Clone:	Polyclonal antibody
Concentration:	1ug per 1ul
Source:	KLH conjugated synthetic phosphopeptide derived from human CHK2 around the phosphorylation site of Thr387
Gene ID number:	11200
Tested applications:	IF(IHC-P)
Recommended dilutions:	IF(IHC-P)(1:50-200)
Crossreactivity:	Mouse, Rat, Human
Crossreactive species details:	not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Antigen background:	Chk2 inhibits CDC25C phosphatase by phosphorylating it on Ser-216, Chk2 is the mammalian ortholog of the budding yeast Rad53 and fission yeast Cds1 checkpoint kinases, Indeed, Kinase activity is up regulated by autophosphorylation and the protein is rapidly phosphorylated in response to DNA damage and to replication block, Phosphorylation at Thr68 is a prerequisite for the subsequent activation step, Ser28, Ser33, Ser35, Ser50 and Thr68) followed by glutamine (SQ or TQ motif), The SQ/TQ cluster domain, The amino-terminal domain of Chk2 contains a series of seven serine and threonine residues (Ser19, These are known to be preferred sites for phosphorylation by ATM/ATR kinases, This kinase may have a role in meiosis as well, Thr26, Thr68 and other sites in this region become phosphorylated by ATM/ATR, UV irradiation or hydroxyurea treatment, after DNA damage by ionizing radiation (IR), and may also participate in transduction of the DNA damage and replicational stress signals, preventing the entry into mitosis, seems to have a regulatory function, therefore, which is attributable to autophosphorylation of Chk2 on residues Thr383 and Thr387 in the activation loop of the kinase domain, Chk2 is a serine/threonine kinase involved in the control of cell cycle checkpoints
Purification method:	This antibody was purified via Protein A
Storage conditions:	50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA
Excitation Emission:	512, 550nm/570, 615nm
Synonyms:	CDS1 CHK2 HuCds1 PP1425 bA444G7
Properties:	1 of the CHK2 (Thr387) Antibody, Conjugated can be used in flow cytometry but typically shows lower fluorescence intensity comparable to that of PE or APC, Cy3 antibodies are excited by the 488-nanometer wave of an argon laser and the 633-nanometer line of a helium-neon diode laser, This Bioss Primary Conjugated Antibodies antibody is well suited for fluorescent microscopy, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°
Gene target:	CHK2 (Thr387) Conjugated
Short name:	Conjugated, CHK2 (Thr387) Antibody
Technique:	antibodies against human proteins, antibodies for, antibody Conjugates, Antibody
Label:	Cy3
Alternative name:	cyanine 3 coupled, CHK2 (Thr387) (Antibody to)
Alternative technique:	antibodies
Identity:	16627
Gene:	CHEK2 | More about : CHEK2
Long gene name:	checkpoint kinase 2
Synonyms gene:	RAD53
Synonyms gene name:	CHK2 (checkpoint, S, pombe) , pombe) homolog CHK2 checkpoint homolog (S
Locus:	22q12, 1
Discovery year:	2001-09-19
GenBank acession:	AF086904
Entrez gene record:	11200
Pubmed identfication:	9836640 10097108
RefSeq identity:	NM_001005735
Havana BLAST/BLAT:	OTTHUMG00000151023
Locus Specific Databases:	LRG_302

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