| Long name: |
ALEXA FLUOR 594 Conjugated, CDKN2A (Ser8) Polyclonal Antibody |
| Also known as: |
Anti-CDKN2A Ser8 PAb ALEXA FLUOR 594 |
| Category: |
Conjugated Primary Antibodies |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
CDKN2A Ser8 |
| Specificity: |
This is a highly specific antibody against CDKN2A Ser8 |
| Modification: |
Phosphorylation |
| Modification Site: |
Ser8 |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Source: |
KLH conjugated synthetic phosphopeptide derived from human CDKN2A around the phosphorylation site of Ser8 [GS(p-S)ME] |
| Gene ID Number: |
1029 |
| Tested applications: |
IF(IHC-P) |
| Recommended dilutions: |
IF(IHC-P)(1:50-200) |
| Crossreactivity: |
Human |
| Cross-reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the antigen: |
At least three alternatively spliced variants encoding distinct proteins have been reported, In spite of the structural and functional differences, Sep 2012], The remaining transcript includes an alternate first exon located 20 Kb upstream of the remainder of the gene, This ARF product functions as a stabilizer of the tumor suppressor protein p53 as it can interact with, This gene is frequently mutated or deleted in a wide variety of tumors, [provided by RefSeq, a protein responsible for the degradation of p53, and is known to be an important tumor suppressor gene, and sequester, share a common functionality in cell cycle G1 control, the CDK inhibitor isoforms and the ARF product encoded by this gene, the E3 ubiquitin-protein ligase MDM2, this transcript contains an alternate open reading frame (ARF) that specifies a protein which is structurally unrelated to the products of the other variants, through the regulatory roles of CDK4 and p53 in cell cycle G1 progression, two of which encode structurally related isoforms known to function as inhibitors of CDK4 kinase, This gene generates several transcript variants which differ in their first exons |
| Purification: |
Purified by Protein A |
| Storage conditions: |
50% glycerol and 0, Keep refrigerated at 2 to 8 degrees Celcius for up to one year, 09% sodium azide, Store this antibody in aqueous buffered solution containing 1% BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
CDK4I p16 INK4a MTS1 CMM2 ARF p19 p14 INK4 p16INK4a p19Arf p14ARF |
| Properties: |
ALEXA FLUOR they should be stored frozen at - 24°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies, C, C for long term storage and for short term at + 5°, For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
594, ALEXA FLUOR®, Alexa Fluor |
| Conjugated: |
Alexa conjugate 1 |
| Gene target: |
CDKN2A (Ser8) |
| Short name: |
CDKN2A (Ser8) Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Label: |
ALEXA FLUOR 594 |
| Alternative name: |
ALEXA FLUOR 594, cyclin-dependent kinase inhibitor 2A (Ser8) (Antibody to) |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
ARF and CDK4I and CDKN2 and CMM2 and INK4 and INK4A and MLM and MTS-1 and MTS1 and P14 and P14ARF and P16 and P16-INK4A and P16INK4 and P16INK4A and P19 and P19ARF and TP16, CDKN2A and IDBG-54547 and ENSG00000147889 and 1029, CDKN2A and IDBG-630043 and ENSBTAG00000034220 and 616369, DNA-templated and biological process this GO :0006364 and rRNA processing and biological process this GO :0006469 and negative regulation of protein kinase activity and biological process this GO :0006919 and activation of cysteine-type endopeptidase activity involved in apoptotic process and biological process this GO :0007050 and cell cycle arrest and biological process this GO :0007265 and Ras protein signal transduction and biological process this GO :0008134 and transcription factor binding and molecular function this GO :0008285 and negative regulation of cell proliferation and biological process this GO :0008637 and apoptotic mitochondrial changes and biological process this GO :0010389 and regulation of G2/M transition of mitotic cell cycle and biological process this GO :0016301 and kinase activity and molecular function this GO :0016310 and phosphorylation and biological process this GO :0016604 and nuclear body and cellular component this GO :0019901 and protein kinase binding and molecular function this GO :0030308 and negative regulation of cell growth and biological process this GO :0030889 and negative regulation of B cell proliferation and biological process this GO :0031647 and regulation of protein stability and biological process this GO :0031648 and protein destabilization and biological process this GO :0032088 and negative regulation of NF-kappaB transcription factor activity and biological process this GO :0033088 and negative regulation of immature T cell proliferation in thymus and biological process this GO :0033235 and positive regulation of protein sumoylation and biological process this GO :0034393 and positive regulation of smooth muscle cell apoptotic process and biological process this GO :0035985 and senescence-associated heterochromatin focus and cellular component this GO :0035986 and senescence-associated heterochromatin focus assembly and biological process this GO :0042326 and negative regulation of phosphorylation and biological process this GO :0043234 and protein complex and cellular component this GO :0043517 and positive regulation of DNA damage response, DNA-templated and biological process this GO :0045893 and positive regulation of transcription, DNA-templated and biological process this GO :0045944 and positive regulation of transcription from RNA polymerase II promoter and biological process this GO :0046825 and regulation of protein export from nucleus and biological process this GO :0048103 and somatic stem cell division and biological process this GO :0050821 and protein stabilization and biological process this GO :0051059 and NF-kappaB binding and molecular function this GO :0051444 and negative regulation of ubiquitin-protein transferase activity and biological process this GO :0055105 and ubiquitin-protein transferase inhibitor activity and molecular function this GO :0070534 and protein K63-linked ubiquitination and biological process this GO :0071158 and positive regulation of cell cycle arrest and biological process this GO :0090398 and cellular senescence and biological process this GO :0090399 and replicative senescence and biological process this GO :0097371 and MDM2/MDM4 family protein binding and molecular function this GO :1902510 and regulation of apoptotic DNA fragmentation and biological process this GO :2000111 and positive regulation of macrophage apoptotic process and biological process this GO :2000774 and positive regulation of cellular senescence and biological process, MDM2/MDM4 family protein binding, nuclei, signal transduction by p53 class mediator and biological process this GO :0044822 and poly(A) RNA binding and molecular function this GO :0045087 and innate immune response and biological process this GO :0045736 and negative regulation of cyclin-dependent protein serine/threonine kinase activity and biological process this GO :0045892 and negative regulation of transcription, this GO :0000075 and cell cycle checkpoint and biological process this GO :0000082 and G1/S transition of mitotic cell cycle and biological process this GO :0000209 and protein polyubiquitination and biological process this GO :0000278 and mitotic cell cycle and biological process this GO :0001953 and negative regulation of cell-matrix adhesion and biological process this GO :0002039 and p53 binding and molecular function this GO :0003677 and DNA binding and molecular function this GO :0004861 and cyclin-dependent protein serine/threonine kinase inhibitor activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005654 and nucleoplasm and cellular component this GO :0005730 and nucleolus and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0005739 and mitochondrion and cellular component this GO :0005829 and cytosol and cellular component this GO :0006351 and transcription, this GO :0002039 : p53 binding, this GO :0002039 : p53 binding and also this GO :0003677 : DNA binding and also this GO :0004861 : cyclin-dependent protein serine/threonine kinase inhibitor activity and also this GO :0005515 : protein binding and also this GO :0008134 : transcription factor binding and also this GO :0016301 : kinase activity and also this GO :0019901 : protein kinase binding and also this GO :0044822 : poly(A) RNA binding and also this GO :0051059 : NF-kappaB binding and also this GO :0055105 : ubiquitin-protein transferase inhibitor activity and also this GO :0097371 : MDM2/MDM4 family protein binding, this GO :0003677 : DNA binding, this GO :0004861 : cyclin-dependent protein serine/threonine kinase inhibitor activity, this GO :0005515 : protein binding, this GO :0008134 : transcription factor binding, this GO :0016301 : kinase activity, this GO :0019901 : protein kinase binding, this GO :0044822 : poly(A) RNA binding, this GO :0051059 : NF-kappaB binding, this GO :0055105 : ubiquitin-protein transferase inhibitor activity, this GO :0097371 : MDM2/MDM4 family protein binding, cyclin-dependent kinase inhibitor 2A |
| Identity: |
1787 |
| Gene: |
CDKN2A |
More about : CDKN2A |
| Long gene name: |
cyclin dependent kinase inhibitor 2A |
| Synonyms gene: |
CDKN2 MLM |
| Synonyms gene name: |
cyclin-dependent kinase inhibitor 2A (melanoma, inhibits CDK4) , p16 |
| Locus: |
9p21, 3 |
| Discovery year: |
1994-05-19 |
| GenBank acession: |
L27211 |
| Entrez gene record: |
1029 |
| Pubmed identfication: |
8152487 7606716 |
| RefSeq identity: |
NM_000077 |
| Havana BLAST/BLAT: |
OTTHUMG00000019686 |
| Locus Specific Databases: |
LOVD - Leiden Open Variation Database LRG_11 |