| Long name: |
ALEXA FLUOR 350 Conjugated, Bad (Ser118) Polyclonal Antibody |
| Also known as: |
Anti-Bad Ser118 PAb ALEXA FLUOR 350 |
| Category: |
Conjugated Primary Antibodies |
| Conjugated with: |
350, ALEXA FLUOR® |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
Bad Ser118 |
| Specificity: |
This is a highly specific antibody against Bad Ser118 |
| Modification: |
Phosphorylation |
| Modification Site: |
Ser118 |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Source: |
KLH conjugated synthetic phosphopeptide derived from human BAD around the phosphorylation site of Ser118 |
| Gene ID Number: |
572 |
| Tested applications: |
IF(IHC-P) |
| Recommended dilutions: |
IF(IHC-P)(1:50-200) |
| Crossreactivity: |
Mouse, Rat, Human |
| Cross-reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the antigen: |
Alternative splicing of this gene results in two transcript variants which encode the same isoform, Bad is found on the outer mitochondrial membrane and, Cdc2-induced phosphorylation of Bad serine 128 has an inhibitory effect on its interaction with 14-3-3 proteins, JNK-induced phosphorylation of BAD serine 128 promotes the apoptotic role of Bad by opposing the inhibitory effect of growth factor on Bad-mediated apoptosis, The latter interaction is critical for Bad phosphorylation at serine 155, The phosphorylation status of Bad represents a key checkpoint for death or cell survival, a site within the BH3 domain that leads to the release of BclxL and the promotion of cell survival, once phosphorylated in response to growth stimuli, thus preventing them from binding with BAX, translocates to the cytoplasm, Bad is a member of the Bcl2 family and acts to promote apoptosis by forming heterodimers with the survival proteins Bcl2 and BclxL |
| Purification: |
Purified by Protein A |
| Storage conditions: |
50% glycerol and 0, Keep refrigerated at 2 to 8 degrees Celcius for up to one year, 09% sodium azide, Store this antibody in aqueous buffered solution containing 1% BSA |
| Excitation emission: |
343nm/442nm |
| Synonyms: |
BBC 2, BBC2, BBC6, BCL X / BCL 2 Binding Protein, Bad phospho Ser118, Bcl 2 Antagonist of Cell Death, Bcl 2 Binding Component 6, mouse BAD Ser155, p-Bad S118, p-Bad phospho Ser118, rat BAD Ser156, Bad phospho S118, p- Bad Ser118 |
| Properties: |
ALEXA FLUOR they should be stored frozen at - 24°, Alexa Fluor 350 conjugates can be used in multi-color flow cytometry with FACS's equipped with a second red laser or red diode, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies, C, C for long term storage and for short term at + 5°, For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
ALEXA FLUOR 350, Alexa Fluor |
| Gene target: |
Bad (Ser118) |
| Short name: |
Bad (Ser118) Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Label: |
ALEXA FLUOR 350 |
| Alternative name: |
ALEXA FLUOR 350, BCL2-associated a this GO nist on cell death (Ser118) (Antibody to) |
| Alternative technique: |
antibodies |