| Long name: |
ALEXA FLUOR 555 Conjugated, KAT2B Polyclonal Antibody |
| Also known as: |
Anti-KAT2B PAb ALEXA FLUOR 555 |
| Category: |
Conjugated Primary Antibodies |
| Conjugated with: |
555, ALEXA FLUOR® |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
KAT2B |
| Specificity: |
This is a highly specific antibody against KAT2B |
| Modification: |
Unmodified |
| Modification Site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen range: |
460-510/832 |
| Subcellular location: |
Nucleus |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human KAT2B |
| Gene ID Number: |
5591 |
| Swiss Prot: |
P78527 |
| Tested applications: |
IF(IHC-P) |
| Recommended dilutions: |
IF(IHC-P)(1:50-200) |
| Crossreactivity: |
Mouse, Rat, Human |
| Cross-reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the antigen: |
Ability to phosphorylate p53/TP53 in the presence of supercoiled DNA is dependent on C1D, Also involved in modulation of transcription, Can phosphorylate C1D not only in the presence of linear DNA but also in the presence of supercoiled DNA, Contributes to the determination of the circadian period length by antagonizing phosphorylation of CRY1 'Ser-588' and increasing CRY1 protein stability, DHX9, Found at the ends of chromosomes, HSPCA, Interacts with CRY1 and CRY2, Involved in DNA non-homologous end joining (NHEJ) required for double-strand break (DSB) repair and V(D)J recombination, MYC and RFA2, May also act as a scaffold protein to aid the localization of DNA repair proteins to the site of damage, Must be bound to DNA to express its catalytic properties, PARP1, POU2F1, Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX, Phosphorylates DCLRE1C, Promotes processing of hairpin DNA structures in V(D)J recombination by activation of the hairpin endonuclease artemis (DCLRE1C), Recognizes the substrate consensus sequence [ST]-Q, Required to protect and align broken ends of DNA, SRF, The assembly of the DNA-PK complex at DNA ends is also required for the NHEJ ligation step, WRN, XRCC1, XRCC1, XRCC4, XRCC5, XRCC6, c-Abl/ABL1, c-jun/JUN, histone H1, most likely through an indirect machanism, negatively regulates CRY1 phosphorylation, p53/TP53, suggesting a further role in the maintenance of telomeric stability and the prevention of chromosomal end fusion, thereby regulating DNA damage response mechanism, Serine/threonine-protein kinase that acts as a molecular sensor for DNA damage |
| Purification: |
Purified by Protein A |
| Storage conditions: |
50% glycerol and 0, Keep refrigerated at 2 to 8 degrees Celcius for up to one year, 09% sodium azide, Store this antibody in aqueous buffered solution containing 1% BSA |
| Excitation emission: |
553nm/568nm |
| Synonyms: |
P/CAF GCN5 GCN5L |
| Properties: |
ALEXA FLUOR they should be stored frozen at - 24°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies, Very high photo stable ALEXA conjugate, C, C for long term storage and for short term at + 5°, For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
ALEXA FLUOR 555, Alexa Fluor |
| Gene target: |
KAT2B |
| Short name: |
KAT2B Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Label: |
ALEXA FLUOR 555 |
| Alternative name: |
ALEXA FLUOR 555, KAT2B (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
8638 |
| Gene: |
KAT2B |
More about : KAT2B |
| Long gene name: |
lysine acetyltransferase 2B |
| Synonyms gene: |
PCAF |
| Synonyms gene name: |
p300/CBP-associated factor K(lysine) acetyltransferase 2B |
| Locus: |
3p24, 3 |
| Discovery year: |
1999-02-10 |
| GenBank acession: |
U57316 |
| Entrez gene record: |
8850 |
| Pubmed identfication: |
8684459 9722949 |
| RefSeq identity: |
NM_003884 |
| Classification: |
Lysine acetyltransferases GCN5 related N-acetyltransferases ATAC complex SAGA complex |
| Havana BLAST/BLAT: |
OTTHUMG00000130481 |