| Long name: |
(Phospho-Tyr857) Primary Polyclonal Antibody, PDGF Receptor &beta |
| Also known as: |
(Phospho-Tyr857) PAb, PDGF Receptor &beta |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
(Phospho-Tyr857), PDGF Receptor &beta |
| Specificity: |
(Phospho-Tyr857), This is a highly specific antibody against PDGF Receptor &beta |
| Modification(s): |
Phosphorylation |
| Modification site(s): |
Tyr857 |
| Clonality: |
Polyclonal antibody |
| Clone number: |
Polyclonal antibody |
| Source: |
Synthetic phospholyrated peptide (KLH coupled) corresponding to residues surrounding Tyr 857 of human PDGF Receptor |
| Gene ID number: |
5159 |
| Swiss Prot: |
P09619 |
| Tested Applications: |
WB |
| Recommended dilutions: |
WB (1:2000) |
| Cross reactivity: |
Mouse, Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1, Binding of its cognate ligands - homodimeric PDGFB, CBL, PIK3R1, PTPN11, Phosphorylates PLCG1, Phosphorylation of PIK3R1, Phosphorylation of SHC1, Plays a role in the migration of vascular smooth muscle cells and the formation of neointima at vascular injury sites, Plays an essential role in blood vessel development by promoting proliferation, Promotes rearrangement of the actin cytoskeleton and the formation of membrane ruffles, RAF1 and down-stream MAP kinases, RASA1/GAP, Required for normal development of the cardiovascular system, Required for normal recruitment of pericytes (mesangial cells) in the kidney glomerulus, SHC1 and NCK1, and for normal formation of a branched network of capillaries in kidney glomeruli, and plays an essential role in the regulation of embryonic development, cell proliferation, chemotaxis and migration, creates a binding site for GRB2, differentiation, heterodimers formed by PDGFA and PDGFB or homodimeric PDGFD -leads to the activation of several signaling cascades, including MAPK1/ERK2 and/or MAPK3/ERK1, leads to the activation of the AKT1 signaling pathway, migration and recruitment of pericytes and smooth muscle cells to endothelial cells, mobilization of cytosolic Ca(2+) and the activation of protein kinase C, or of the C-terminus of PTPN11, resulting in the activation of HRAS, survival, the regulatory subunit of phosphatidylinositol 3-kinase, the response depends on the nature of the bound ligand and is modulated by the formation of heterodimers between PDGFRA and PDGFRB, 4, 5-trisphosphate, Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
Beta platelet-derived growth factor receptor, Beta-type platelet-derived growth factor receptor, CD140 antigen-like family member B, CD140B, IBGC4, JTK12, KOGS, PDGF-R-beta, PDGFR, PDGFR-1, PDGFR-beta, PDGFR1, PDGFRB, PENTT, Platelet-derived growth factor receptor 1, Platelet-derived growth factor receptor beta, IMF1 |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
(Phospho-Tyr857), PDGF Receptor &beta |
| Short name: |
(Phospho-Tyr857) Antibody, PDGF Receptor &beta |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
(phosphorilated-Tyr857) (Antibody to), PDGF Receptor &beta |
| Alternative technique: |
antibodies |