| Long name: |
Cy3 Conjugated, VAV3 Polyclonal Antibody |
| Category: |
Conjugated Primary Antibodies |
| Conjugation: |
cy3 conjugation kit |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
VAV3 |
| Specificity: |
This is a highly specific antibody against VAV3 |
| Modification: |
Unmodified |
| Modification site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen_range: |
710-760/847 |
| Subcellular location: |
Cytoplasm |
| Source: |
KLH conjugated synthetic peptide derived from mouse VAV3 |
| Gene ID number: |
57257 |
| Swiss Prot: |
Q9R0C8 |
| Tested applications: |
IF(IHC-P) |
| Recommended dilutions: |
IF(IHC-P)(1:50-200) |
| Crossreactivity: |
Mouse, Rat, Human |
| Crossreactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Antigen background: |
Binds physically to the nucleotide-free states of those GTPases (By similarity), Does not affect integrin beta-1-mediated adhesion, In osteoclasts, In the course of wound healing, Its recruitment by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly, May be important for integrin-mediated signaling, Necessary for proper wound healing, Plays an important role in angiogenesis, Rac1, Responsible for integrin beta-2-mediated macrophage adhesion and, RhoG and, This signaling pathway involves RAC1, a crucial event for osteoclast proper cytoskeleton organization and function, activation, along with SYK tyrosine kinase, at least in some cell types, but not RHO, contributes to beta-3-mediated adhesion, required for signaling through integrin alpha-v/beta-1 (ITAGV-ITGB1), required for the phagocytotic cup formation preceding macrophage phagocytosis of apoptotic neutrophils, to a lesser extent, to a lesser extent, Exchange factor for GTP-binding proteins RhoA |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA |
| Excitation Emission: |
512, 550nm/570, 615nm |
| Properties: |
1 of the VAV3 Antibody, Conjugated can be used in flow cytometry but typically shows lower fluorescence intensity comparable to that of PE or APC, Cy3 antibodies are excited by the 488-nanometer wave of an argon laser and the 633-nanometer line of a helium-neon diode laser, This Bioss Primary Conjugated Antibodies antibody is well suited for fluorescent microscopy, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
VAV3 Conjugated |
| Short name: |
Conjugated, VAV3 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, antibody Conjugates, Antibody |
| Label: |
Cy3 |
| Alternative name: |
cyanine 3 coupled, vav 3 guanine nucleotide exchange factor (Antibody to) |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
Plasma membranes, VAV3 and IDBG-100649 and ENSG00000134215 and 10451, VAV3 and IDBG-635847 and ENSBTAG00000031575 and 521961, Vav3 and IDBG-188386 and ENSMUSG00000033721 and 57257, metal ion binding, this GO :0001525 and angiogenesis and biological process this GO :0005070 and SH3/SH2 adaptor activity and molecular function this GO :0005085 and guanyl-nucleotide exchange factor activity and molecular function this GO :0005089 and Rho guanyl-nucleotide exchange factor activity and molecular function this GO :0005096 and GTPase activator activity and molecular function this GO :0005154 and epidermal growth factor receptor binding and molecular function this GO :0005515 and protein binding and molecular function this GO :0005737 and cytoplasm and cellular component this GO :0005829 and cytosol and cellular component this GO :0005886 and plasma membrane and cellular component this GO :0006906 and vesicle fusion and biological process this GO :0006974 and cellular response to DNA damage stimulus and biological process this GO :0007229 and integrin-mediated signaling pathway and biological process this GO :0007264 and small GTPase mediated signal transduction and biological process this GO :0007596 and blood coagulation and biological process this GO :0009967 and positive regulation of signal transduction and biological process this GO :0016477 and cell migration and biological process this GO :0030031 and cell projection assembly and biological process this GO :0030032 and lamellipodium assembly and biological process this GO :0030168 and platelet activation and biological process this GO :0030593 and neutrophil chemotaxis and biological process this GO :0030676 and Rac guanyl-nucleotide exchange factor activity and molecular function this GO :0030890 and positive regulation of B cell proliferation and biological process this GO :0032314 and regulation of Rac GTPase activity and biological process this GO :0032319 and regulation of Rho GTPase activity and biological process this GO :0032321 and positive regulation of Rho GTPase activity and biological process this GO :0035023 and regulation of Rho protein signal transduction and biological process this GO :0035556 and intracellular signal transduction and biological process this GO :0038095 and Fc-epsilon receptor signaling pathway and biological process this GO :0038096 and Fc-gamma receptor signaling pathway involved in pha this GO cytosis and biological process this GO :0042493 and response to drug and biological process this GO :0043065 and positive regulation of apoptotic process and biological process this GO :0043087 and regulation of GTPase activity and biological process this GO :0043547 and positive regulation of GTPase activity and biological process this GO :0043552 and positive regulation of phosphatidylinositol 3-kinase activity and biological process this GO :0045087 and innate immune response and biological process this GO :0045785 and positive regulation of cell adhesion and biological process this GO :0046872 and metal ion binding and molecular function this GO :0048011 and neurotrophin TRK receptor signaling pathway and biological process this GO :0050853 and B cell receptor signaling pathway and biological process this GO :0051056 and regulation of small GTPase mediated signal transduction and biological process this GO :0070062 and extracellular vesicular exosome and cellular component this GO :0097190 and apoptotic signaling pathway and biological process, this GO :0005070 : SH3/SH2 adaptor activity, this GO :0005070 : SH3/SH2 adaptor activity and also this GO :0005085 : guanyl-nucleotide exchange factor activity and also this GO :0005089 : Rho guanyl-nucleotide exchange factor activity and also this GO :0005096 : GTPase activator activity and also this GO :0005154 : epidermal growth factor receptor binding and also this GO :0005515 : protein binding and also this GO :0030676 : Rac guanyl-nucleotide exchange factor activity and also this GO :0046872 : metal ion binding, this GO :0005085 : guanyl-nucleotide exchange factor activity, this GO :0005089 : Rho guanyl-nucleotide exchange factor activity, this GO :0005096 : GTPase activator activity, this GO :0005154 : epidermal growth factor receptor binding, this GO :0005515 : protein binding, this GO :0030676 : Rac guanyl-nucleotide exchange factor activity, this GO :0046872 : metal ion binding, vav 3 guanine nucleotide exchange factor |
| Identity: |
12659 |
| Gene: |
VAV3 |
More about : VAV3 |
| Long gene name: |
vav guanine nucleotide exchange factor 3 |
| Synonyms gene name: |
vav 3 oncogene vav 3 guanine nucleotide exchange factor |
| Locus: |
1p13, 3 |
| Discovery year: |
1999-07-07 |
| GenBank acession: |
AF118886 |
| Entrez gene record: |
10451 |
| RefSeq identity: |
NM_006113 |
| Classification: |
Rho guanine nucleotide exchange factors Pleckstrin homology domain containing SH2 domain containing |
| Havana BLAST/BLAT: |
OTTHUMG00000010995 |