| Long name: |
CHMP1A Primary Polyclonal Antibody |
| Also known as: |
CHMP1A PAb |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
CHMP1A |
| Specificity: |
This is a highly specific antibody against CHMP1A |
| Modification(s): |
None |
| Modification site(s): |
Unmodified antibody |
| Clonality: |
Polyclonal antibody |
| Clone number: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen range: |
70-120/196 |
| Subcellular location: |
Cell membrane, Nucleus, Cytoplasm |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human CHMP1A |
| Gene ID number: |
5119 |
| Swiss Prot: |
Q9HD42 |
| Tested Applications: |
IF(IHC-P), IHC-P, WB |
| Recommended dilutions: |
IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity: |
Mouse, Rat, Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
-I, ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released, Involved in cytokinesis, Involved in recruiting VPS4A and/or VPS4B to the midbody of dividing cells, MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, May also be involved in chromosome condensation, May play a role in stable cell cycle progression and in PcG gene silencing, Targets the Polycomb group (PcG) protein BMI1/PCGF4 to regions of condensed chromatin, The ESCRT machinery also functions in topologically equivalent membrane fission events, The MVB pathway appears to require the sequential function of ESCRT-O, lysosomal enzymes and lipids, possibly in conjunction with the AAA ATPase VPS4, such as stimulated growth factor receptors, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses), -II and -III complexes, Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
CHMP1, CHMP1a, Charged multivesicular body protein 1a, Chromatin-modifying protein 1a, KIAA0047, PCOLN3, PRSM1, VPS46-1, VPS46A, Vacuolar protein sorting-associated protein 46-1, hVps46-1, PCH8 |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
CHMP1A |
| Short name: |
CHMP1A Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
CHMP1A (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
8740 |
| Gene: |
CHMP1A |
More about : CHMP1A |
| Long gene name: |
charged multivesicular body protein 1A |
| Synonyms gene: |
PRSM1 PCOLN3 |
| Synonyms gene name: |
procollagen (type III) N-endopeptidase chromatin modifying protein 1A |
| Synonyms: |
KIAA0047 CHMP1 Vps46A |
| Locus: |
16q24, 3 |
| Discovery year: |
1993-05-03 |
| GenBank acession: |
U58048 |
| Entrez gene record: |
5119 |
| Pubmed identfication: |
11559748 11559747 |
| RefSeq identity: |
NM_002768 |
| Classification: |
Charged multivesicular body proteins ESCRT-III associated factors |
| Havana BLAST/BLAT: |
OTTHUMG00000169521 |