| Long name: |
FITC Conjugated, LRP5 Polyclonal Antibody |
| Category: |
Conjugated Primary Antibodies |
| Conjugation: |
Anti-FITC Antibody |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
LRP5 |
| Specificity: |
This antibody will recognize LRP6 due to high sequence similarity, This is a highly specific antibody against LRP5 |
| Modification: |
Unmodified |
| Modification site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen_range: |
500-550/1615 |
| Subcellular location: |
Extracellular |
| Source: |
KLH conjugated synthetic peptide derived from human LRP5 |
| Gene ID number: |
4041 |
| Swiss Prot: |
O75197 |
| Tested applications: |
IF(IHC-P) |
| Recommended dilutions: |
IF(IHC-P)(1:50-200) |
| Crossreactivity: |
Mouse, Rat, Human |
| Crossreactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Antigen background: |
Appears be required for postnatal control of vascular regression in the eye, Cell-surface coreceptor of Wnt/beta-catenin signaling, Required for posterior patterning of the epiblast during gastrulation, The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalsomes and inhibiting AXIN1/GSK3-mediated phosphorylation and destruction of beta-catenin, which plays a pivotal role in bone formation, Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA |
| Excitation Emission: |
494nm/518nm |
| Synonyms: |
LR3 BMND1 HBM OPS OPTA1 VBCH2 EVR4 |
| Properties: |
Bioss Primary Conjugated Antibodies FITC is highly sensitive to pH extremes, FITC has a green emission that's usually collected at 530 nanometers, FITC has a high quantum yield (efficiency of energy transfer from absorption to emission fluorescence) and approximately half of the absorbed photons are emitted as fluorescent light, For fluorescent microscopy applications, This Bioss Primary Conjugated Antibodies Fluorescein isothiocyanate (FITC) antibody is currently after some BD antibodies the most commonly used fluorescent dye for FACS, When excited at 488 nanometers, its photo bleaching effects are not observed due to a very brief interaction at the laser intercept, the 1 FITC is seldom used as it photo bleaches rather quickly though in flow cytometry applications, the FL1 detector of a FACSCalibur or FACScan, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
LRP5 Conjugated |
| Short name: |
FITC Conjugated, LRP5 Antibody |
| Technique: |
Fluorescein, antibodies against human proteins, antibodies for, antibody Conjugates, Antibody |
| Label: |
FITC |
| Alternative name: |
fluorecein coupled, low density lipoprotein receptor-related protein 5 (Antibody to) |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
BMND1 and EVR1 and EVR4 and HBM and LR3 and LRP-5 and LRP7 and OPPG and OPS and OPTA1 and VBCH2, DNA-templated and biological process this GO :0045944 and positive regulation of transcription from RNA polymerase II promoter and biological process this GO :0046849 and bone remodeling and biological process this GO :0046850 and regulation of bone remodeling and biological process this GO :0048539 and bone marrow development and biological process this GO :0048596 and embryonic camera-type eye morphogenesis and biological process this GO :0051091 and positive regulation of sequence-specific DNA binding transcription factor activity and biological process this GO :0060033 and anatomical structure regression and biological process this GO :0060042 and retina morphogenesis in camera-type eye and biological process this GO :0060059 and embryonic retina morphogenesis in camera-type eye and biological process this GO :0060070 and canonical Wnt signaling pathway and biological process this GO :0060348 and bone development and biological process this GO :0060349 and bone morphogenesis and biological process this GO :0060444 and branching involved in mammary gland duct morphogenesis and biological process this GO :0060603 and mammary gland duct morphogenesis and biological process this GO :0060612 and adipose tissue development and biological process this GO :0060764 and cell-cell signaling involved in mammary gland development and biological process this GO :0060828 and regulation of canonical Wnt signaling pathway and biological process this GO :0061178 and regulation of insulin secretion involved in cellular response to glucose stimulus and biological process this GO :0061299 and retina vasculature morphogenesis in camera-type eye and biological process this GO :0061304 and retinal blood vessel morphogenesis and biological process this GO :0071901 and negative regulation of protein serine/threonine kinase activity and biological process this GO :1902262 and apoptotic process involved in patterning of blood vessels and biological process, LRP5 and IDBG-61383 and ENSG00000162337 and 4041, LRP5 and IDBG-644859 and ENSBTAG00000005903 and 534450, Lrp5 and IDBG-128306 and ENSMUSG00000024913 and 16973, Plasma membranes, Wnt-activated receptor activity, this GO :0001702 and gastrulation with mouth forming second and biological process this GO :0001944 and vasculature development and biological process this GO :0002053 and positive regulation of mesenchymal cell proliferation and biological process this GO :0002076 and osteoblast development and biological process this GO :0005515 and protein binding and molecular function this GO :0005739 and mitochondrion and cellular component this GO :0005783 and endoplasmic reticulum and cellular component this GO :0005886 and plasma membrane and cellular component this GO :0006007 and glucose catabolic process and biological process this GO :0006897 and endocytosis and biological process this GO :0008203 and cholesterol metabolic process and biological process this GO :0008217 and regulation of blood pressure and biological process this GO :0008284 and positive regulation of cell proliferation and biological process this GO :0009952 and anterior/posterior pattern specification and biological process this GO :0015026 and coreceptor activity and molecular function this GO :0016021 and integral component of membrane and cellular component this GO :0016055 and Wnt signaling pathway and biological process this GO :0017147 and Wnt-protein binding and molecular function this GO :0030326 and embryonic limb morphogenesis and biological process this GO :0033690 and positive regulation of osteoblast proliferation and biological process this GO :0035019 and somatic stem cell maintenance and biological process this GO :0035108 and limb morphogenesis and biological process this GO :0035426 and extracellular matrix-cell signaling and biological process this GO :0042074 and cell migration involved in gastrulation and biological process this GO :0042632 and cholesterol homeostasis and biological process this GO :0042733 and embryonic digit morphogenesis and biological process this GO :0042813 and Wnt-activated receptor activity and molecular function this GO :0042981 and regulation of apoptotic process and biological process this GO :0043235 and receptor complex and cellular component this GO :0043434 and response to peptide hormone and biological process this GO :0044332 and Wnt signaling pathway involved in dorsal/ventral axis specification and biological process this GO :0045600 and positive regulation of fat cell differentiation and biological process this GO :0045668 and negative regulation of osteoblast differentiation and biological process this GO :0045840 and positive regulation of mitosis and biological process this GO :0045893 and positive regulation of transcription, this GO :0005515 : protein binding, this GO :0005515 : protein binding and also this GO :0015026 : coreceptor activity and also this GO :0017147 : Wnt-protein binding and also this GO :0042813 : Wnt-activated receptor activity, this GO :0015026 : coreceptor activity, this GO :0017147 : Wnt-protein binding, this GO :0042813 : Wnt-activated receptor activity, low density lipoprotein receptor-related protein 5 |
| Identity: |
6697 |
| Gene: |
LRP5 |
More about : LRP5 |
| Long gene name: |
LDL receptor related protein 5 |
| Synonyms gene: |
LRP7 OPPG EVR1 |
| Synonyms gene name: |
osteoporosis pseudoglioma syndrome exudative vitreoretinopathy 1 low density lipoprotein receptor-related protein 5 |
| Locus: |
11q13, 2 |
| Discovery year: |
1998-04-07 |
| GenBank acession: |
AF064548 |
| Entrez gene record: |
4041 |
| Pubmed identfication: |
9714764 10049586 |
| RefSeq identity: |
NM_002335 |
| Classification: |
Low density lipoprotein receptors |
| Havana BLAST/BLAT: |
OTTHUMG00000167570 |
| Locus Specific Databases: |
LOVD - Leiden Open Variation Database |