| Long name: |
IKBKE Primary Polyclonal Antibody |
| Also known as: |
IKBKE PAb |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
IKBKE |
| Specificity: |
This is a highly specific antibody against IKBKE |
| Modification(s): |
None |
| Modification site(s): |
Unmodified antibody |
| Clonality: |
Polyclonal antibody |
| Clone number: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen range: |
530-580/716 |
| Subcellular location: |
Nucleus, Cytoplasm |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human IKBKE |
| Gene ID number: |
9641 |
| Swiss Prot: |
Q14164 |
| Tested Applications: |
IF(IHC-P), IHC-P, WB |
| Recommended dilutions: |
IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity: |
Mouse, Rat, Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
AZI2/NAP1 or TBKBP1/SINTBAD can be recruited to the IKBKE-containing-complexes, Activated by polyubiquitination in response to TNFA and interleukin-1, Also involved in TNFA and inflammatory cytokines, Also plays an important role in energy balance regulation by sustaining a state of chronic, Following activation of viral RNA sensors, IKBKE forms several different complexes whose composition depends on the type of cell and cellular stimuli, IRF3 and IRF7, In addition, In order to establish such an antiviral state, NF-kappa-B and STAT signaling, Phosphorylates AKT1, Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor, Phosphorylation of STAT1 at 'Ser-708' seems also to promote the assembly and DNA binding of ISGF3 (STAT1:STAT2:IRF9) complexes compared to GAF (STAT1:STAT1) complexes, Protects cells against DNA damage-induced cell death, TANK, This activity allows subsequent homodimerization and nuclear translocation of the IRF3 leading to transcriptional activation of pro-inflammatory and antiviral genes including IFNB, Thus, as well as DDX3X, associates with DDX3X and phosphorylates interferon regulatory factors (IRFs), at least, in this way regulating the balance between type I and type II IFN responses, is also required for the induction of a subset of ISGs which displays antiviral activity, like Interleukin-1, low-grade inflammation in obesity, may be through the phosphorylation of STAT1 at 'Ser-708', regulates the NF-kappa-B signaling pathway through, several scaffolding molecules including IPS1/MAVS, signaling, such as RIG-I-like receptors, the phosphorylation of CYLD, through the activation of the type I IFN, wich leads to a negative impact on insulin sensitivity, Serine/threonine kinase that plays an essential role in regulating inflammatory responses to viral infection |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
I-kappa-B kinase epsilon, IKK-E, IKK-epsilon, IKK-i, IKKI, IkBKE, Inducible I kappa-B kinase, Inhibitor of nuclear factor kappa-B kinase subunit epsilon, KIAA0151, IKKE |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
IKBKE |
| Short name: |
IKBKE Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
kinase epsilon (Antibody to), inhibitor on kappa light polypeptide gene enhancer in B-cells |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
BT, IKBKE and IDBG-776557 and ENSG00000263528 and 9641, IKK-E and IKK-i and IKKE and IKKI, Ikbke and IDBG-190983 and ENSMUSG00000042349 and 56489, kinase epsilon, nuclei, this GO :0002224 and toll-like receptor signaling pathway and biological process this GO :0002756 and MyD88-independent toll-like receptor signaling pathway and biological process this GO :0004672 and protein kinase activity and molecular function this GO :0004704 and NF-kappaB-inducing kinase activity and molecular function this GO :0004713 and protein tyrosine kinase activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005524 and ATP binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0005829 and cytosol and cellular component this GO :0006468 and protein phosphorylation and biological process this GO :0006955 and immune response and biological process this GO :0007252 and I-kappaB phosphorylation and biological process this GO :0008384 and IkappaB kinase activity and molecular function this GO :0008630 and intrinsic apoptotic signaling pathway in response to DNA damage and biological process this GO :0010008 and endosome membrane and cellular component this GO :0016605 and PML body and cellular component this GO :0016772 and transferase activity, this GO :0004672 : protein kinase activity, this GO :0004672 : protein kinase activity and also this GO :0004704 : NF-kappaB-inducing kinase activity and also this GO :0004713 : protein tyrosine kinase activity and also this GO :0005515 : protein binding and also this GO :0005524 : ATP binding and also this GO :0008384 : IkappaB kinase activity and also this GO :0016772 : transferase activity, this GO :0004704 : NF-kappaB-inducing kinase activity, this GO :0004713 : protein tyrosine kinase activity, this GO :0005515 : protein binding, this GO :0005524 : ATP binding, this GO :0008384 : IkappaB kinase activity, this GO :0016772 : transferase activity, transferase activity, transferring phosphorus-containing groups, transferring phosphorus-containing groups, transferring phosphorus-containing groups and molecular function this GO :0032480 and negative regulation of type I interferon production and biological process this GO :0034138 and toll-like receptor 3 signaling pathway and biological process this GO :0034142 and toll-like receptor 4 signaling pathway and biological process this GO :0035666 and TRIF-dependent toll-like receptor signaling pathway and biological process this GO :0038061 and NIK/NF-kappaB signaling and biological process this GO :0043123 and positive regulation of I-kappaB kinase/NF-kappaB signaling and biological process this GO :0045087 and innate immune response and biological process, 54851 and IDBG-629048 and ENSBTAG00000010408 and 533216, inhibitor of kappa light polypeptide gene enhancer in B-cells |
| Identity: |
14552 |
| Gene: |
IKBKE |
More about : IKBKE |
| Long gene name: |
inhibitor of nuclear factor kappa B kinase subunit epsilon |
| Synonyms gene name: |
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon |
| Synonyms: |
IKKE IKK-i KIAA0151 |
| Locus: |
1q32, 1 |
| Discovery year: |
2002-12-02 |
| GenBank acession: |
AB016590 |
| Entrez gene record: |
9641 |
| Pubmed identfication: |
10421793 10882136 |
| Havana BLAST/BLAT: |
OTTHUMG00000184613 |