| Long name: |
LATS2 (Ser83) Primary Polyclonal Antibody |
| Also known as: |
LATS2 (Ser83) PAb |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
LATS2 Ser83 |
| Specificity: |
This phosphorylation site is homologous to that of Ser82 in Mouse and Ser83 Rat, This is a highly specific antibody against LATS2 Ser83 |
| Modification(s): |
Phosphorylation |
| Modification site(s): |
Ser83 |
| Clonality: |
Polyclonal antibody |
| Clone number: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen range: |
70-100/1088 |
| Subcellular location: |
Nucleus, Cytoplasm |
| Source: |
KLH conjugated synthetic phosphopeptide derived from human LATS2 around the phosphorylation site of Ser83 |
| Gene ID number: |
26524 |
| Swiss Prot: |
Q9NRM7 |
| Tested Applications: |
IF(IHC-P), IHC-P, WB |
| Recommended dilutions: |
IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity: |
Mouse, Rat, Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
Acts as a tumor suppressor which plays a critical role in centrosome duplication, Negative regulator of the androgen receptor, Negatively regulates G1/S transition by down-regulating cyclin E/CDK2 kinase activity, Phosphorylates SNAI1 in the nucleus leading to its nuclear retention and stabilization, Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, This tumor-promoting activity is independent of its effects upon YAP1 or WWTR1/TAZ, and cell migration, cell death, in complex with its regulatory protein SAV1, maintenance of mitotic fidelity and genomic stability, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which enhances its epithelial-mesenchymal transition and tumor cell invasion/migration activities, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ, Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
Kinase phosphorylated during mitosis protein, LATS2, Large tumor suppressor homolog 2, Serine/threonine-protein kinase LATS2, Serine/threonine-protein kinase kpm, Warts-like kinase, KPM |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
LATS2 (Ser83) |
| Short name: |
LATS2 (Ser83) Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
homolog 2 (Drosophila) (Ser83) (Antibody to), large tumor suppressor, LATS |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
LATS2 and IDBG-13987 and ENSG00000150457 and 26524, LATS2 and IDBG-631161 and ENSBTAG00000014406 and, Lats2 and IDBG-168883 and ENSMUSG00000021959 and 50523, homolog 2 (Drosophila), large tumor suppressor, nuclei, this GO :0000082 and G1/S transition of mitotic cell cycle and biological process this GO :0000922 and spindle pole and cellular component this GO :0004672 and protein kinase activity and molecular function this GO :0004674 and protein serine/threonine kinase activity and molecular function this GO :0004713 and protein tyrosine kinase activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005524 and ATP binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005815 and microtubule organizing center and cellular component this GO :0005829 and cytosol and cellular component this GO :0006468 and protein phosphorylation and biological process this GO :0007067 and mitotic nuclear division and biological process this GO :0009755 and hormone-mediated signaling pathway and biological process this GO :0016772 and transferase activity, this GO :0004672 : protein kinase activity, this GO :0004672 : protein kinase activity and also this GO :0004674 : protein serine/threonine kinase activity and also this GO :0004713 : protein tyrosine kinase activity and also this GO :0005515 : protein binding and also this GO :0005524 : ATP binding and also this GO :0016772 : transferase activity, this GO :0004674 : protein serine/threonine kinase activity, this GO :0004713 : protein tyrosine kinase activity, this GO :0005515 : protein binding, this GO :0005524 : ATP binding, this GO :0016772 : transferase activity, this GO :0046872 : metal ion binding, transferase activity, transferring phosphorus-containing groups, transferring phosphorus-containing groups and also this GO :0046872 : metal ion binding, transferring phosphorus-containing groups and molecular function this GO :0030216 and keratinocyte differentiation and biological process this GO :0034613 and cellular protein localization and biological process this GO :0035329 and hippo signaling and biological process this GO :0035556 and intracellular signal transduction and biological process this GO :0045736 and negative regulation of cyclin-dependent protein serine/threonine kinase activity and biological process this GO :0046620 and regulation of organ growth and biological process this GO :0046872 and metal ion binding and molecular function this GO :0090090 and negative regulation of canonical Wnt signaling pathway and biological process, LATS |
| Identity: |
6515 |
| Gene: |
LATS2 |
More about : LATS2 |
| Long gene name: |
large tumor suppressor kinase 2 |
| Synonyms gene name: |
Drosophila) homolog 2 LATS, LATS (large tumor suppressor, homolog 2 (Drosophila) , large tumor suppressor |
| Locus: |
13q12, 11 |
| Discovery year: |
1999-12-07 |
| GenBank acession: |
AB028019 |
| Entrez gene record: |
26524 |
| Pubmed identfication: |
10673337 |
| Havana BLAST/BLAT: |
OTTHUMG00000016531 |