HER2 (Thr686) Antibody, Cy7 Conjugated

Catalog number:	bs-4004R-Cy7 Buy Now
Price:	350 €
Supplier:	Bioss Primary Conjugated Antibodies
Product name:	HER2 (Thr686) Antibody, Cy7 Conjugated
Quantity:	0.1ml
Related search:	thr antibody erbb cell homolog activation

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Long name:	Cy7 Conjugated, HER2 (Thr686) Polyclonal Antibody
Category:	Conjugated Primary Antibodies
Conjugation:	Cy7
Host Organism:	Rabbit (Oryctolagus cuniculus)
Target Antigen:	HER2 Thr686
Specificity:	This phosphorylation site is homologous to that of Thr687 in Mouse and Thr688 in Rat, This is a highly specific antibody against HER2 Thr686
Modification:	Phosphorylation
Modification site:	Thr686
Clonality:	Polyclonal
Clone:	Polyclonal antibody
Concentration:	1ug per 1ul
Immunogen_range:	660-700/1255
Subcellular location:	Cytoplasm
Source:	KLH conjugated synthetic phosphopeptide derived from human HER2 around the phosphorylation site of Thr686
Gene ID number:	2064
Swiss Prot:	P04626
Tested applications:	IF(IHC-P)
Recommended dilutions:	IF(IHC-P)(1:50-200)
Crossreactivity:	Mouse, Rat, Human
Crossreactive species details:	not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Antigen background:	Associates with the 5'-TCAAATTC-3' sequence in the PTGS2/COX-2 promoter and activates its transcription, Essential component of a neuregulin-receptor complex, GP30 is a potential ligand for this receptor, Implicated in transcriptional activation of CDKN1A, In the nucleus is involved in transcriptional regulation, In turn, Involved in the transcription of rRNA genes by RNA Pol I and enhances protein synthesis and cell growth, Regulates outgrowth and stabilization of peripheral microtubules (MTs), This prevents the phosphorylation of APC and CLASP2, Upon ERBB2 activation, allowing its association with the cell membrane, although neuregulins do not interact with it alone, but that apparently needs a coreceptor for ligand binding, membrane-bound APC allows the localization of MACF1 to the cell membrane, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane, the function involves STAT3 and SRC, which is required for microtubule capture and stabilization, Protein tyrosine kinase that is part of several cell surface receptor complexes
Purification method:	This antibody was purified via Protein A
Storage conditions:	50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA
Excitation Emission:	743nm/767nm
Synonyms:	NEU HER-2 CD340 HER2
Properties:	C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°
Conjugated:	These antibodies are excite for emission at 650 nm and detected at a 676 nm wavelengths
Gene target:	HER2 (Thr686) Conjugated
Short name:	Conjugated, HER2 (Thr686) Antibody
Technique:	antibodies against human proteins, antibodies for, antibody Conjugates, Antibody
Label:	Cy7
Alternative name:	cyanine 7 coupled, HER2 (Thr686) (Antibody to)
Alternative technique:	antibodies
Identity:	3430
Gene:	ERBB2 | More about : ERBB2
Long gene name:	erb-b2 receptor tyrosine kinase 2
Synonyms gene:	NGL
Synonyms gene name:	v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog) v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2
Synonyms name:	neuro/glioblastoma derived oncogene homolog human epidermal growth factor receptor 2
Locus:	17q12
Discovery year:	2001-06-22
GenBank acession:	X03363
Entrez gene record:	2064
RefSeq identity:	NM_004448
Classification:	CD molecules Minor histocompatibility antigens Erb-b2 receptor tyrosine kinases
Havana BLAST/BLAT:	OTTHUMG00000179300
Locus Specific Databases:	LRG_724

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• #antibody
• #erbb
• #cell
• #homolog
• #activation