| Long name: |
HER2 (Thr686) Primary Polyclonal Antibody |
| Also known as: |
HER2 (Thr686) PAb |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
HER2 Thr686 |
| Specificity: |
This phosphorylation site is homologous to that of Thr687 in Mouse and Thr688 in Rat, This is a highly specific antibody against HER2 Thr686 |
| Modification(s): |
Phosphorylation |
| Modification site(s): |
Thr686 |
| Clonality: |
Polyclonal antibody |
| Clone number: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen range: |
660-700/1255 |
| Subcellular location: |
Cytoplasm |
| Source: |
KLH conjugated synthetic phosphopeptide derived from human HER2 around the phosphorylation site of Thr686 |
| Gene ID number: |
2064 |
| Swiss Prot: |
P04626 |
| Tested Applications: |
IF(IHC-P), IHC-P, WB |
| Recommended dilutions: |
IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity: |
Mouse, Rat, Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
Associates with the 5'-TCAAATTC-3' sequence in the PTGS2/COX-2 promoter and activates its transcription, Essential component of a neuregulin-receptor complex, GP30 is a potential ligand for this receptor, Implicated in transcriptional activation of CDKN1A, In the nucleus is involved in transcriptional regulation, In turn, Involved in the transcription of rRNA genes by RNA Pol I and enhances protein synthesis and cell growth, Regulates outgrowth and stabilization of peripheral microtubules (MTs), This prevents the phosphorylation of APC and CLASP2, Upon ERBB2 activation, allowing its association with the cell membrane, although neuregulins do not interact with it alone, but that apparently needs a coreceptor for ligand binding, membrane-bound APC allows the localization of MACF1 to the cell membrane, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane, the function involves STAT3 and SRC, which is required for microtubule capture and stabilization, Protein tyrosine kinase that is part of several cell surface receptor complexes |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
CD340, ERBB2, HER-2, HER-2/neu, HER2, MLN 19, MLN19, Metastatic lymph node gene 19 protein, NGL, Proto-oncogene Neu, Proto-oncogene c-ErbB-2, Receptor tyrosine-protein kinase erbB-2, TKR1, Tyrosine kinase-type cell surface receptor HER2, p185erbB2, NEU |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
HER2 (Thr686) |
| Short name: |
HER2 (Thr686) Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
HER2 (Thr686) (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
3430 |
| Gene: |
ERBB2 |
More about : ERBB2 |
| Long gene name: |
erb-b2 receptor tyrosine kinase 2 |
| Synonyms gene: |
NGL |
| Synonyms gene name: |
v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog) v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 |
| Synonyms: |
NEU HER-2 CD340 HER2 |
| Synonyms name: |
neuro/glioblastoma derived oncogene homolog human epidermal growth factor receptor 2 |
| Locus: |
17q12 |
| Discovery year: |
2001-06-22 |
| GenBank acession: |
X03363 |
| Entrez gene record: |
2064 |
| RefSeq identity: |
NM_004448 |
| Classification: |
CD molecules Minor histocompatibility antigens Erb-b2 receptor tyrosine kinases |
| Havana BLAST/BLAT: |
OTTHUMG00000179300 |
| Locus Specific Databases: |
LRG_724 |