| Catalog number: | bs-3969R-A350 |
|---|---|
| Price: | 332 € |
| Supplier: | Bioss Primary Conjugated Antibodies. |
| Product name: | PRKAR1 Antibody, ALEXA FLUOR 350 |
| Quantity: | 100ul |
| Related search: |
| Long name: | ALEXA FLUOR 350 Conjugated, PRKAR1 Polyclonal Antibody |
|---|---|
| Also known as: | Anti-PRKAR1 PAb ALEXA FLUOR 350 |
| Category: | Conjugated Primary Antibodies |
| Conjugated with: | 350, ALEXA FLUOR® |
| Host Organism: | Rabbit (Oryctolagus cuniculus) |
| Target Antigen: | PRKAR1 |
| Specificity: | This is a highly specific antibody against PRKAR1 |
| Modification: | Unmodified |
| Modification Site: | None |
| Clonality: | Polyclonal |
| Clone: | Polyclonal antibody |
| Concentration: | 1ug per 1ul |
| Source: | This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human Protein Kinase A regulatory subunit I alpha |
| Gene ID Number: | 5573 |
| Tested applications: | IF(IHC-P) |
| Recommended dilutions: | IF(IHC-P)(1:50-200) |
| Crossreactivity: | Mouse, Rat, Human |
| Cross-reactive species details: | not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the antigen: | A nonconventional nuclear localization sequence (NLS) has been found for this protein which suggests a role in DNA replication via the protein serving as a nuclear transport protein for the second subunit of the Replication Factor C (RFC40), Four different regulatory subunits and three catalytic subunits have been identified in humans, Jul 2008], Mutations in this gene cause Carney complex (CNC), The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits, This gene can fuse to the RET protooncogene by gene rearrangement and form the thyroid tumor-specific chimeric oncogene known as PTC2, This gene encodes one of the regulatory subunits, This protein was found to be a tissue-specific extinguisher that down-regulates the expression of seven liver genes in hepatoma x fibroblast hybrids, Three alternatively spliced transcript variants encoding the same protein have been observed, [provided by RefSeq, cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits, cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins, cAMP is a signaling molecule important for a variety of cellular functions |
| Purification: | Purified by Protein A |
| Storage conditions: | 50% glycerol and 0, Keep refrigerated at 2 to 8 degrees Celcius for up to one year, 09% sodium azide, Store this antibody in aqueous buffered solution containing 1% BSA |
| Excitation emission: | 343nm/442nm |
| Synonyms: | CNC1 |
| Properties: | ALEXA FLUOR they should be stored frozen at - 24°, Alexa Fluor 350 conjugates can be used in multi-color flow cytometry with FACS's equipped with a second red laser or red diode, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies, C, C for long term storage and for short term at + 5°, For facs or microscopy Alexa 1 conjugate |
| Conjugation: | ALEXA FLUOR 350, Alexa Fluor |
| Gene target: | PRKAR1 |
| Short name: | PRKAR1 Antibody |
| Technique: | antibodies against human proteins, antibodies for, Antibody |
| Label: | ALEXA FLUOR 350 |
| Alternative name: | ALEXA FLUOR 350, PRKAR1 (Antibody to) |
| Alternative technique: | antibodies |
| Identity: | 9388 |
| Gene: | PRKAR1A | More about : PRKAR1A |
| Long gene name: | protein kinase cAMP-dependent type I regulatory subunit alpha |
| Synonyms gene: | PRKAR1 TSE1 |
| Synonyms gene name: | alpha protein kinase, cAMP-dependent, cAMP-dependent, regulatory, regulatory subunit type I alpha , tissue specific extinguisher 1 protein kinase, type I |
| Synonyms name: | Carney complex type 1 |
| Locus: | 17q24, 2 |
| Discovery year: | 1988-05-11 |
| Entrez gene record: | 5573 |
| Pubmed identfication: | 3479018 10973256 |
| Havana BLAST/BLAT: | OTTHUMG00000180128 |
| Locus Specific Databases: | LRG_514 |
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