| Long name: |
ALEXA FLUOR 647 Conjugated, KDM1A Polyclonal Antibody |
| Also known as: |
Anti-KDM1A PAb ALEXA FLUOR 647 |
| Category: |
Conjugated Primary Antibodies |
| Conjugated with: |
647, ALEXA FLUOR® |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
KDM1A |
| Specificity: |
This is a highly specific antibody against KDM1A |
| Modification: |
Unmodified |
| Modification Site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen range: |
120-170/852 |
| Subcellular location: |
Nucleus |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human KDM1A |
| Gene ID Number: |
23028 |
| Swiss Prot: |
O60341 |
| Tested applications: |
IF(IHC-P) |
| Recommended dilutions: |
IF(IHC-P)(1:50-200) |
| Crossreactivity: |
Mouse, Rat, Human |
| Cross-reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the antigen: |
Acts as a corepressor by mediating demethylation of H3K4me, Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed, Alone, Also acts as a coactivator of androgen receptor (ANDR)-dependent transcription, CDN7 and KRT8, Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, Demethylates and stabilizes the DNA methylase DNMT1, Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me, Demethylates di-methylated 'Lys-370' of p53/TP53 which prevents interaction of p53/TP53 with TP53BP1 and represses p53/TP53-mediated transcriptional activation, Effector of SNAI1-mediated transcription repression of E-cadherin/CDH1, May play a role in the repression of neuronal genes, Required for gastrulation during embryogenesis, Required for the maintenance of the silenced state of the SNAI1 target genes E-cadherin/CDH1 and CDN7, The presence of PRKCB in ANDR-containing complexes, a number of genes implicated in multilineage blood cell development, a specific tag for epigenetic transcriptional activation, a specific tag for epigenetic transcriptional repression, a specific tag that prevents demethylation H3K4me, by being recruited to ANDR target genes and mediating demethylation of H3K9me, depending on the context, it is unable to demethylate H3K4me on nucleosomes and requires the presence of RCOR1/CoREST to achieve such activity, prevents H3K4me demethylase activity of KDM1A, thereby acting as a coactivator or a corepressor, via histone deacetylase (HDAC) recruitment, which mediates phosphorylation of 'Thr-6' of histone H3 (H3T6ph), Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3 |
| Purification: |
Purified by Protein A |
| Storage conditions: |
50% glycerol and 0, Keep refrigerated at 2 to 8 degrees Celcius for up to one year, 09% sodium azide, Store this antibody in aqueous buffered solution containing 1% BSA |
| Excitation emission: |
650nm/665nm |
| Synonyms: |
KIAA0601 BHC110 LSD1 |
| Properties: |
ALEXA FLUOR made this Alexa Fluor 633 conjugate that can be used in multi-color flow cytometry with instruments equipped with a second red laser or red diode, ALEXA FLUOR they should be stored frozen at - 24°, Alexa Fluor 633 is a practical alternative to APC as well as Cy5, Bioss Primary Conjugated Antibodies, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies, It is detected in the FL4 detector of the core's upgraded 2-laser FACScans, Like other Alexa Fluor dyes, exhibits uncommon photo stability, making it an ideal choice for fluorescent microscopy, the KDM1A Antibody, C, C for long term storage and for short term at + 5°, For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
ALEXA FLUOR 647, Alexa Fluor |
| Gene target: |
KDM1A |
| Short name: |
KDM1A Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Label: |
ALEXA FLUOR 647 |
| Alternative name: |
ALEXA FLUOR 647, KDM1A (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
29079 |
| Gene: |
KDM1A |
More about : KDM1A |
| Long gene name: |
lysine demethylase 1A |
| Synonyms gene: |
AOF2 KDM1 |
| Synonyms gene name: |
amine oxidase (flavin containing) domain 2 lysine (K)-specific demethylase 1 |
| Locus: |
1p36, 12 |
| Discovery year: |
2004-02-26 |
| GenBank acession: |
AL031428 |
| Entrez gene record: |
23028 |
| Pubmed identfication: |
9628581 12493763 |
| RefSeq identity: |
NM_015013 |
| Classification: |
Lysine demethylases |
| Havana BLAST/BLAT: |
OTTHUMG00000003220 |