| Long name: |
FLASH/CASP8AP2 Primary Polyclonal Antibody |
| Also known as: |
FLASH/CASP8AP2 PAb |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
FLASH/CASP8AP2 |
| Specificity: |
This is a highly specific antibody against FLASH/CASP8AP2 |
| Modification(s): |
None |
| Modification site(s): |
Unmodified antibody |
| Clonality: |
Polyclonal antibody |
| Clone number: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human FLASH/CASP8AP2 |
| Gene ID number: |
9994 |
| Tested Applications: |
IF(IHC-P), IHC-P, WB |
| Recommended dilutions: |
IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity: |
Mouse, Rat, Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
FLASH interacts with the DEDs of caspase-8 and FADD through the DED-like domain of FLASH and mediates activation of caspase-8, Fas binding adapter FADD, It is recruited to Fas after the receptor cross-linking, Overexpression of wild type of FLASH facilitates and its dominant negative form inhibits Fas induced apoptosis, There are parallels between FLASH and Apaf-1/CED-4 although there are arguments against their structural similarity, and caspase 8, and plays a regulatory role in Fas mediated apoptosis, FLASH is involved in Fas induced apoptosis, Studies of FLASH protein suggested that this protein may be a component of the death inducing signaling complex that includes Fas receptor |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
AA387232, C8AP2_HUMAN, CASP8 associated protein 2, CASP8-associated protein 2, CASP8AP2, CED 4, CED4, Caspase 8 associated protein 2, D4Ertd659e, FLASH homolog, FLASH homolog RIP 25, FLASH homolog RIP25, FLICE associated huge, FLICE associated huge protein, FLICE-associated huge protein, FLICE-associated huge protein, FLJ11208, KIAA1315, OTTMUSP00000005125, RIP 25, RIP25, RP23-69G24, mKIAA1315, 1, CASP 8 associated protein 2 |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
FLASH/CASP8AP2 |
| Short name: |
FLASH/CASP8AP2 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
FLASH/caspase 8 associated protein 2 (Antibody to) |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
BT, CASP8AP2 and IDBG-94347 and ENSG00000118412 and 9994, CED-4 and FLASH and RIP25, Casp8ap2 and IDBG-133238 and ENSMUSG00000028282 and 26885, identical protein binding, multiple, this GO :0002020 and protease binding and molecular function this GO :0003677 and DNA binding and molecular function this GO :0005515 and protein binding and molecular function this GO :0006919 and activation of cysteine-type endopeptidase activity involved in apoptotic process and biological process this GO :0008625 and extrinsic apoptotic signaling pathway via death domain receptors and biological process this GO :0008656 and cysteine-type endopeptidase activator activity involved in apoptotic process and molecular function this GO :0042802 and identical protein binding and molecular function, this GO :0002020 : protease binding, this GO :0002020 : protease binding and also this GO :0003677 : DNA binding and also this GO :0005515 : protein binding and also this GO :0008656 : cysteine-type endopeptidase activator activity involved in apoptotic process and also this GO :0042802 : identical protein binding, this GO :0003677 : DNA binding, this GO :0005515 : protein binding, this GO :0008656 : cysteine-type endopeptidase activator activity involved in apoptotic process, this GO :0042802 : identical protein binding, 102649 and IDBG-632350 and ENSBTAG00000011313 and 505138, caspase 8 associated protein 2 |
| Identity: |
1510 |
| Gene: |
CASP8AP2 |
More about : CASP8AP2 |
| Long gene name: |
caspase 8 associated protein 2 |
| Synonyms gene name: |
CASP8 associated protein 2 |
| Synonyms: |
FLASH CED-4 RIP25 FLJ11208 KIAA1315 |
| Synonyms name: |
FLICE-associated huge protein |
| Locus: |
6q15 |
| Discovery year: |
1999-12-10 |
| GenBank acession: |
AB037736 |
| Entrez gene record: |
9994 |
| Pubmed identfication: |
10235259 17245429 17003126 |
| RefSeq identity: |
NM_001137667 |
| Havana BLAST/BLAT: |
OTTHUMG00000015212 |