| Long name: |
ALEXA FLUOR 594 Conjugated, SIAH1/2 Polyclonal Antibody |
| Also known as: |
Anti-SIAH1/2 PAb ALEXA FLUOR 594 |
| Category: |
Conjugated Primary Antibodies |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
SIAH1/2 |
| Specificity: |
This is a highly specific antibody against SIAH1/2 |
| Modification: |
Unmodified |
| Modification Site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen range: |
200-250/324 |
| Subcellular location: |
Nucleus, Cytoplasm |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human SIAH2 |
| Gene ID Number: |
6477, 6478 |
| Swiss Prot: |
Q8IUQ4, O43255 |
| Tested applications: |
IF(IHC-P) |
| Recommended dilutions: |
IF(IHC-P)(1:50-200) |
| Crossreactivity: |
Mouse, Rat, Human |
| Cross-reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the antigen: |
BAG1), DCC), E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targets, NCOR1), PML, POU2AF1, SYP), Siah2 has some overlapping function with SIAH1 but is able to trigger the ubiquitin-mediated degradation of TRAF2, Siah2 triggers the ubiquitin-mediated degradation of many proteins, and proteins involved in synaptic vesicle function in neurons (e, antiapoptotic proteins (e, cell surface receptors (e, including transcription regulators (e, whereas SIAH1 can not, Siah2 is a E3 Ubiquitin ligase protein that mediates ubiquitination and subsequent proteasomal degradation of target proteins, g, g, g, g |
| Purification: |
Purified by Protein A |
| Storage conditions: |
50% glycerol and 0, Keep refrigerated at 2 to 8 degrees Celcius for up to one year, 09% sodium azide, Store this antibody in aqueous buffered solution containing 1% BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
hSIAH1 |
| Properties: |
ALEXA FLUOR they should be stored frozen at - 24°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies, C, C for long term storage and for short term at + 5°, For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
594, ALEXA FLUOR®, Alexa Fluor |
| Conjugated: |
Alexa conjugate 1 |
| Gene target: |
SIAH1/2 |
| Short name: |
SIAH1/2 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Label: |
ALEXA FLUOR 594 |
| Alternative name: |
ALEXA FLUOR 594, siah E3 ubiquitin protein ligase 1/2 (Antibody to) |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
BT, SIAH1 and IDBG-30112 and ENSG00000196470 and 6477, SIAH1A, ligase activity, nuclei, this GO :0004842 and ubiquitin-protein transferase activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0005769 and early endosome and cellular component this GO :0005829 and cytosol and cellular component this GO :0005886 and plasma membrane and cellular component this GO :0006508 and proteolysis and biological process this GO :0006511 and ubiquitin-dependent protein catabolic process and biological process this GO :0006915 and apoptotic process and biological process this GO :0007049 and cell cycle and biological process this GO :0007275 and multicellular organismal development and biological process this GO :0007283 and spermatogenesis and biological process this GO :0007399 and nervous system development and biological process this GO :0007411 and axon guidance and biological process this GO :0008022 and protein C-terminus binding and molecular function this GO :0008270 and zinc ion binding and molecular function this GO :0009653 and anatomical structure morphogenesis and biological process this GO :0016874 and ligase activity and molecular function this GO :0030163 and protein catabolic process and biological process this GO :0030877 and beta-catenin destruction complex and cellular component this GO :0031648 and protein destabilization and biological process this GO :0042787 and protein ubiquitination involved in ubiquitin-dependent protein catabolic process and biological process this GO :0043065 and positive regulation of apoptotic process and biological process this GO :0043161 and proteasome-mediated ubiquitin-dependent protein catabolic process and biological process this GO :0045087 and innate immune response and biological process this GO :0051402 and neuron apoptotic process and biological process this GO :2001244 and positive regulation of intrinsic apoptotic signaling pathway and biological process, this GO :0004842 : ubiquitin-protein transferase activity, this GO :0004842 : ubiquitin-protein transferase activity and also this GO :0005515 : protein binding and also this GO :0008022 : protein C-terminus binding and also this GO :0008270 : zinc ion binding and also this GO :0016874 : ligase activity, this GO :0005515 : protein binding, this GO :0008022 : protein C-terminus binding, this GO :0008270 : zinc ion binding, this GO :0016874 : ligase activity, 37798 and IDBG-631496 and ENSBTAG00000010868 and 534655, siah E3 ubiquitin protein ligase 1 |
| Identity: |
10857 |
| Gene: |
SIAH1 |
More about : SIAH1 |
| Long gene name: |
siah E3 ubiquitin protein ligase 1 |
| Synonyms gene name: |
seven in absentia homolog 1 (Drosophila) |
| Locus: |
16q12, 1 |
| Discovery year: |
1997-09-12 |
| GenBank acession: |
U76247 |
| Entrez gene record: |
6477 |
| Pubmed identfication: |
9403064 9334332 |
| Havana BLAST/BLAT: |
OTTHUMG00000175417 |