| Long name: |
ALEXA FLUOR 488 Conjugated, p90RSK Polyclonal Antibody |
| Also known as: |
Anti-p90RSK PAb ALEXA FLUOR 488 |
| Category: |
Conjugated Primary Antibodies |
| Conjugated with: |
488, ALEXA FLUOR® |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
p90RSK |
| Specificity: |
This is a highly specific antibody against p90RSK |
| Modification: |
Unmodified |
| Modification Site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen range: |
650-700/732 |
| Subcellular location: |
Nucleus, Cytoplasm |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human p90RSK |
| Gene ID Number: |
6195 |
| Swiss Prot: |
Q15418 |
| Tested applications: |
IF(IHC-P) |
| Recommended dilutions: |
IF(IHC-P)(1:50-200) |
| Crossreactivity: |
Mouse, Rat, Human |
| Cross-reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the antigen: |
ETV1/ER81 and NR4A1/NUR77, In fibroblast, In response to insulin, In response to mitogenic stimulation (EGF and PMA), Is involved in the mTOR nutrient-sensing pathway by directly phosphorylating TSC2 at 'Ser-1798', Mediates cell survival by phosphorylating the pro-apoptotic proteins BAD and DAPK1 and suppressing their pro-apoptotic function, Mediates induction of hepatocyte prolifration by TGFA through phosphorylation of CEBPB (By similarity), Phosphorylates RPS6 in response to serum or EGF via an mTOR-independent mechanism and promotes translation initiation by facilitating assembly of the pre-initiation complex, Promotes the survival of hepatic stellate cells by phosphorylating CEBPB in response to the hepatotoxin carbon tetrachloride (CCl4), Upon insulin-derived signal, acts indirectly on the transcription regulation of several genes by phosphorylating GSK3B at 'Ser-9' and inhibiting its activity, and differentiation by modulating mTOR signaling and repressing pro-apoptotic function of BAD and DAPK1, and mediates cellular proliferation, and mediates phosphorylation of RPTOR, enhancing EIF4B affinity for the EIF3 complex and stimulating cap-dependent translation, is required for EGF-stimulated phosphorylation of CREB1, phosphorylates EIF4B, phosphorylates and activates NR4A1/NUR77 and ETV1/ER81 transcription factors and the cofactor CREBBP, regulates translation through RPS6 and EIF4B phosphorylation, survival, which potently inhibits TSC2 ability to suppress mTOR signaling, which regulates mTORC1 activity and may promote rapamycin-sensitive signaling independently of the PI3K/AKT pathway, which results in the subsequent transcriptional activation of several immediate-early genes, Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of the transcription factors CREB1 |
| Purification: |
Purified by Protein A |
| Storage conditions: |
50% glycerol and 0, Keep refrigerated at 2 to 8 degrees Celcius for up to one year, 09% sodium azide, Store this antibody in aqueous buffered solution containing 1% BSA |
| Excitation emission: |
499nm/519nm |
| Synonyms: |
RSK RSK1 HU-1 p90Rsk |
| Properties: |
ALEXA FLUOR they should be stored frozen at - 24°, Alexa Fluor 488 has the same range to that of fluorescein isothiocyanate (FITC), Also Alexa Fluor 488 is pH stable, As a result of this photo stability, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies, It is distinguished in the FL1 of a FACS-Calibur or FACScan, has a very high photo stability, it has turned into an antibody for fluorescent microscopy and FACS FLOW cytometry, yet the p90RSK Antibody, C, C for long term storage and for short term at + 5°, For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Gene target: |
p90RSK |
| Short name: |
p90RSK Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Label: |
ALEXA FLUOR 488 |
| Alternative name: |
ALEXA FLUOR 488, p90RSK (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
10430 |
| Gene: |
RPS6KA1 |
More about : RPS6KA1 |
| Long gene name: |
ribosomal protein S6 kinase A1 |
| Synonyms gene name: |
90kD, polypeptide 1 , ribosomal protein S6 kinase |
| Locus: |
1p36, 11 |
| Discovery year: |
1994-07-11 |
| GenBank acession: |
BC014966 |
| Entrez gene record: |
6195 |
| Pubmed identfication: |
8141249 |
| RefSeq identity: |
NM_002953 |
| Classification: |
Mitogen-activated protein kinase-activated protein kinases |
| Havana BLAST/BLAT: |
OTTHUMG00000004003 |