| Long name: |
Cy7 Conjugated, VEGFR2 (Tyr1175) Polyclonal Antibody |
| Category: |
Conjugated Primary Antibodies |
| Conjugation: |
Cy7 |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
VEGFR2 Tyr1175 |
| Specificity: |
This phosphorylation site is homologous to that of Ser1173 in Mouse and Ser1171 in Rat, This is a highly specific antibody against VEGFR2 Tyr1175 |
| Modification: |
Phosphorylation |
| Modification site: |
Tyr1175 |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen_range: |
1150-1200/1356 |
| Subcellular location: |
Cell membrane, Cytoplasm |
| Source: |
KLH conjugated synthetic phosphopeptide derived from human VEGFR2 around the phosphorylation site of Tyr1175 |
| Gene ID number: |
3791 |
| Swiss Prot: |
P35968 |
| Tested applications: |
IF(IHC-P) |
| Recommended dilutions: |
IF(IHC-P)(1:50-200) |
| Crossreactivity: |
Mouse, Rat, Human |
| Crossreactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Antigen background: |
Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1, Binding of vascular growth factors to isoform 1 leads to the activation of several signaling cascades, Isoform 2 plays an important role as negative regulator of VEGFA- and VEGFC-mediated lymphangiogenesis by limiting the amount of free VEGFA and/or VEGFC and preventing their binding to FLT4, Isoforms lacking a transmembrane domain, MAPK3/ERK1 and the MAP kinase signaling pathway, Mediates activation of MAPK1/ERK2, Mediates phosphorylation of PIK3R1, Modulates FLT1 and FLT4 signaling by forming heterodimers, NCK1, NOS3, PIK3R1, PTK2/FAK1 and SRC, Phosphorylates PLCG1, Plays an essential role in the regulation of angiogenesis, Promotes phosphorylation of FYN, Promotes proliferation, Promotes reorganization of the actin cytoskeleton, Required for VEGFA-mediated induction of NOS2 and NOS3, VEGFC and VEGFD, VEGFC and/or VEGFD, and embryonic hematopoiesis, as well as of the AKT1 signaling pathway, leading to the production of the signaling molecule nitric oxide (NO) by endothelial cells, may function as decoy receptors for VEGFA, migration and differentiation of endothelial cells, reorganization of the actin cytoskeleton and activation of PTK2/FAK1, such as isoform 2 and isoform 3, survival, the regulatory subunit of phosphatidylinositol 3-kinase, vascular development, vascular permeability, 4, 5-trisphosphate and the activation of protein kinase C, Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA |
| Excitation Emission: |
743nm/767nm |
| Synonyms: |
FLK1 VEGFR VEGFR2 CD309 |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24° |
| Conjugated: |
These antibodies are excite for emission at 650 nm and detected at a 676 nm wavelengths |
| Gene target: |
VEGFR2 (Tyr1175) Conjugated |
| Short name: |
Conjugated, VEGFR2 (Tyr1175) Antibody |
| Technique: |
antibodies against human proteins, antibodies for, antibody Conjugates, Antibody |
| Label: |
Cy7 |
| Alternative name: |
cyanine 7 coupled, VEGFR2 (Tyr1175) (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
6307 |
| Gene: |
KDR |
More about : KDR |
| Long gene name: |
kinase insert domain receptor |
| Synonyms gene name: |
kinase insert domain receptor (a type III receptor tyrosine kinase) |
| Synonyms name: |
vascular endothelial growth factor receptor 2 fetal liver kinase 1 |
| Locus: |
4q12 |
| Discovery year: |
1991-07-10 |
| GenBank acession: |
AF035121 |
| Entrez gene record: |
3791 |
| Pubmed identfication: |
1417831 |
| Classification: |
I-set domain containing CD molecules V-set domain containing Immunoglobulin like domain containing Receptor Tyrosine Kinases |
| Havana BLAST/BLAT: |
OTTHUMG00000128734 |
| Locus Specific Databases: |
The Globin Gene Server |