| Long name: |
MAP3K8 (Ser400) Primary Polyclonal Antibody |
| Also known as: |
MAP3K8 (Ser400) PAb |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
MAP3K8 Ser400 |
| Specificity: |
This phosphorylation site is homologous across the listed species, This is a highly specific antibody against MAP3K8 Ser400 |
| Modification(s): |
Phosphorylation |
| Modification site(s): |
Ser400 |
| Clonality: |
Polyclonal antibody |
| Clone number: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen range: |
370-420/467 |
| Subcellular location: |
Cytoplasm |
| Source: |
KLH conjugated synthetic phosphopeptide derived from human MAP3K8/Tpl2 around the phosphorylation site of Ser400 |
| Gene ID number: |
1326 |
| Swiss Prot: |
P41279 |
| Tested Applications: |
IF(IHC-P), IHC-P, WB |
| Recommended dilutions: |
IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity: |
Mouse, Rat, Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
In adipocytes, In vitro, Involved in mediating host resistance to bacterial infection through negative regulation of type I interferon (IFN) production, Involved in the regulation of T-helper cell differentiation and IFNG expression in T-cells, Isoform 1 shows some transforming activity, May also play a role in the transduction of TNF signals that activate JNK and NF-kappa-B in some cell types, Plays a role in the cell cycle, TLR4-mediated activation of the MAPK/ERK pathway in macrophages, Transduces CD40 and TNFRSF1A signals that activate ERK in B-cells and macrophages, activates MAPK/ERK pathway in an IKBKB-dependent manner in response to IL1B and TNF, activates MAPK/ERK pathway in response to IL1 in an IRAK1-independent manner, although it is much weaker than that of the activated oncogenic variant, and thus may play a role in the regulation of immunoglobulin production, but not insulin, leading to induction of lipolysis, leading to up-regulation of IL8 and CCL4, thus being critical for production of the proinflammatory cytokine TNF-alpha (TNF) during immune responses, Required for lipopolysaccharide (LPS)-induced |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
Cancer Osaka thyroid oncogene, EST, ESTF, MAP3K8, MEKK8, Mitogen-activated protein kinase kinase kinase 8, Proto-oncogene c-Cot, Serine/threonine-protein kinase cot, TPL2, Tpl-2, Tumor progression locus 2, c-COT, COT |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
MAP3K8 (Ser400) |
| Short name: |
MAP3K8 (Ser400) Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
MAP3K8 (Ser400) (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
6860 |
| Gene: |
MAP3K8 |
More about : MAP3K8 |
| Long gene name: |
mitogen-activated protein kinase kinase kinase 8 |
| Synonyms gene: |
COT ESTF |
| Synonyms: |
Tpl-2 EST c-COT MEKK8 |
| Locus: |
10p11, 23 |
| Discovery year: |
1992-09-14 |
| GenBank acession: |
D14497 |
| Entrez gene record: |
1326 |
| Pubmed identfication: |
2072910 8479752 |
| RefSeq identity: |
NM_005204 |
| Classification: |
Mitogen-activated protein kinase kinase kinases |
| Havana BLAST/BLAT: |
OTTHUMG00000017889 |