| Long name: |
FITC Conjugated, Tuberin/TSC2 (Ser939) Antibody |
| Category: |
Conjugated Primary Antibodies |
| Conjugation: |
Anti-FITC Antibody |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
Tuberin/TSC2 Ser939 |
| Specificity: |
This is a highly specific antibody against Tuberin/TSC2 Ser939 |
| Modification: |
Phosphorylation |
| Modification site: |
Ser939 |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Source: |
KLH conjugated synthetic phosphopeptide derived from human Tuberin around the phosphorylation site of Ser939 |
| Gene ID number: |
7249 |
| Tested applications: |
IF(IHC-P) |
| Recommended dilutions: |
IF(IHC-P)(1:50-200) |
| Crossreactivity: |
Mouse, Rat, Human |
| Crossreactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Antigen background: |
At least three isoforms of Tuberin exist, Interaction between hamartin (TSC1) and tuberin may facilitate vesicular docking, It may function in vesicular transport, It specifically stimulates the intrinsic GTPase activity of the Ras related protein RAP1A and RAB5, Mutations in tuberin lead to constitutive activation of RAP1A in tumors, and may also play a role in the regulation of cell growth arrest and in the regulation of transcription mediated by steroid receptors, is implicated as a tumor suppressor, or TSC2 (Tuberous sclerosis complex), suggesting a possible mechanism for its role in regulating cellular growth, Tuberin |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA |
| Excitation Emission: |
494nm/518nm |
| Synonyms: |
tuberin LAM PPP1R160 |
| Properties: |
Bioss Primary Conjugated Antibodies FITC is highly sensitive to pH extremes, FITC has a green emission that's usually collected at 530 nanometers, FITC has a high quantum yield (efficiency of energy transfer from absorption to emission fluorescence) and approximately half of the absorbed photons are emitted as fluorescent light, For fluorescent microscopy applications, This Bioss Primary Conjugated Antibodies Fluorescein isothiocyanate (FITC) antibody is currently after some BD antibodies the most commonly used fluorescent dye for FACS, When excited at 488 nanometers, its photo bleaching effects are not observed due to a very brief interaction at the laser intercept, the 1 FITC is seldom used as it photo bleaches rather quickly though in flow cytometry applications, the FL1 detector of a FACSCalibur or FACScan, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
Tuberin/TSC2 (Ser939) Conjugated |
| Short name: |
FITC Conjugated, Tuberin/TSC2 (Ser939) Antibody |
| Technique: |
Fluorescein, antibodies against human proteins, antibodies for, antibody Conjugates, Antibody |
| Label: |
FITC |
| Alternative name: |
fluorecein coupled, Tuberin/tuberous sclerosis 2 (Ser939) (Antibody to) |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
14-3-3 protein binding, LAM and PPP1R160 and TSC4, TSC2 and IDBG-635000 and ENSBTAG00000020617 and 504985, TSC2 and IDBG-9819 and ENSG00000103197 and 7249, Tsc2 and IDBG-147651 and ENSMUSG00000002496 and 22084, nuclei, this GO :0001666 and response to hypoxia and biological process this GO :0001843 and neural tube closure and biological process this GO :0005096 and GTPase activator activity and molecular function this GO :0005488 and binding and molecular function this GO :0005515 and protein binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0005794 and this GO lgi apparatus and cellular component this GO :0005829 and cytosol and cellular component this GO :0005856 and cytoskeleton and cellular component this GO :0005901 and caveola and cellular component this GO :0006469 and negative regulation of protein kinase activity and biological process this GO :0006606 and protein import into nucleus and biological process this GO :0006897 and endocytosis and biological process this GO :0006953 and acute-phase response and biological process this GO :0007050 and cell cycle arrest and biological process this GO :0007165 and signal transduction and biological process this GO :0007173 and epidermal growth factor receptor signaling pathway and biological process this GO :0007507 and heart development and biological process this GO :0008104 and protein localization and biological process this GO :0008285 and negative regulation of cell proliferation and biological process this GO :0008286 and insulin receptor signaling pathway and biological process this GO :0008543 and fibroblast growth factor receptor signaling pathway and biological process this GO :0014065 and phosphatidylinositol 3-kinase signaling and biological process this GO :0014067 and negative regulation of phosphatidylinositol 3-kinase signaling and biological process this GO :0016020 and membrane and cellular component this GO :0016192 and vesicle-mediated transport and biological process this GO :0019902 and phosphatase binding and molecular function this GO :0030030 and cell projection organization and biological process this GO :0030100 and regulation of endocytosis and biological process this GO :0030178 and negative regulation of Wnt signaling pathway and biological process this GO :0030425 and dendrite and cellular component this GO :0030426 and growth cone and cellular component this GO :0032007 and negative regulation of TOR signaling and biological process this GO :0032320 and positive regulation of Ras GTPase activity and biological process this GO :0033596 and TSC1-TSC2 complex and cellular component this GO :0038095 and Fc-epsilon receptor signaling pathway and biological process this GO :0042803 and protein homodimerization activity and molecular function this GO :0043005 and neuron projection and cellular component this GO :0043025 and neuronal cell body and cellular component this GO :0043231 and intracellular membrane-bounded organelle and cellular component this GO :0043234 and protein complex and cellular component this GO :0043407 and negative regulation of MAP kinase activity and biological process this GO :0043491 and protein kinase B signaling and biological process this GO :0043547 and positive regulation of GTPase activity and biological process this GO :0045087 and innate immune response and biological process this GO :0045121 and membrane raft and cellular component this GO :0045184 and establishment of protein localization and biological process this GO :0045792 and negative regulation of cell size and biological process this GO :0046626 and regulation of insulin receptor signaling pathway and biological process this GO :0046627 and negative regulation of insulin receptor signaling pathway and biological process this GO :0046982 and protein heterodimerization activity and molecular function this GO :0048009 and insulin-like growth factor receptor signaling pathway and biological process this GO :0048011 and neurotrophin TRK receptor signaling pathway and biological process this GO :0048015 and phosphatidylinositol-mediated signaling and biological process this GO :0048471 and perinuclear region of cytoplasm and cellular component this GO :0050680 and negative regulation of epithelial cell proliferation and biological process this GO :0050918 and positive chemotaxis and biological process this GO :0051056 and regulation of small GTPase mediated signal transduction and biological process this GO :0051260 and protein homooli this GO merization and biological process this GO :0051291 and protein heterooli this GO merization and biological process this GO :0051726 and regulation of cell cycle and biological process this GO :0051898 and negative regulation of protein kinase B signaling and biological process this GO :0071889 and 14-3-3 protein binding and molecular function, this GO :0005096 : GTPase activator activity, this GO :0005096 : GTPase activator activity and also this GO :0005488 : binding and also this GO :0005515 : protein binding and also this GO :0019902 : phosphatase binding and also this GO :0042803 : protein homodimerization activity and also this GO :0046982 : protein heterodimerization activity and also this GO :0071889 : 14-3-3 protein binding, this GO :0005488 : binding, this GO :0005515 : protein binding, this GO :0019902 : phosphatase binding, this GO :0042803 : protein homodimerization activity, this GO :0046982 : protein heterodimerization activity, this GO :0071889 : 14-3-3 protein binding, tuberous sclerosis 2 |
| Identity: |
12363 |
| Gene: |
TSC2 |
More about : TSC2 |
| Long gene name: |
tuberous sclerosis 2 |
| Synonyms gene: |
TSC4 |
| Synonyms name: |
protein phosphatase 1, regulatory subunit 160 |
| Locus: |
16p13, 3 |
| Discovery year: |
1989-05-25 |
| GenBank acession: |
AB014460 |
| Entrez gene record: |
7249 |
| Pubmed identfication: |
1303246 7558029 |
| RefSeq identity: |
NM_000548 |
| Classification: |
Protein phosphatase 1 regulatory subunits |
| Havana BLAST/BLAT: |
OTTHUMG00000128745 |
| Locus Specific Databases: |
TSC2 Mutation Database Tuberous sclerosis database LRG_487 |