SHC (Tyr427) Antibody, Cy7 Conjugated

Catalog number:	bs-3412R-Cy7 Buy Now
Price:	333 €
Supplier:	Bioss Primary Conjugated Antibodies
Product name:	SHC (Tyr427) Antibody, Cy7 Conjugated
Quantity:	0.1ml
Related search:	shc antibody tyr pshc signaling year

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Long name:	Cy7 Conjugated, SHC (Tyr427) Polyclonal Antibody
Category:	Conjugated Primary Antibodies
Conjugation:	Cy7
Host Organism:	Rabbit (Oryctolagus cuniculus)
Target Antigen:	SHC Tyr427
Specificity:	This is a highly specific antibody against SHC Tyr427
Modification:	Phosphorylation
Modification site:	Tyr427
Clonality:	Polyclonal
Clone:	Polyclonal antibody
Concentration:	1ug per 1ul
Immunogen_range:	405-455/583
Subcellular location:	Mitochondrion, Cytoplasm
Source:	KLH conjugated synthetic phosphopeptide derived from human SHC around the phosphorylation site of Tyr427
Gene ID number:	6464
Swiss Prot:	P29353
Tested applications:	IF(IHC-P)
Recommended dilutions:	IF(IHC-P)(1:50-200)
Crossreactivity:	Mouse, Rat, Human
Crossreactive species details:	not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Antigen background:	Isoform p46Shc and isoform p52Shc, Isoform p46Shc and isoform p52Shc may thus function as initiators of the Ras signaling cascade in various non-neuronal systems, Isoform p66Shc acts as a downstream target of the tumor suppressor p53 and is indispensable for the ability of stress-activated p53 to induce elevation of intracellular oxidants, Isoform p66Shc does not mediate Ras activation, Participates in a signaling cascade initiated by activated KIT and KITLG/SCF, Participates in signaling downstream of the angiopoietin receptor TEK/TIE2, The expression of isoform p66Shc has been correlated with life span (By similarity), and plays a role in the regulation of endothelial cell migration and sprouting angiogenesis, but is involved in signal transduction pathways that regulate the cellular response to oxidative stress and life span, couple activated receptor tyrosine kinases to Ras via the recruitment of the GRB2/SOS complex and are implicated in the cytoplasmic propagation of mitogenic signals, cytochrome c release and apoptosis, once phosphorylated, Signaling adapter that couples activated growth factor receptors to signaling pathways
Purification method:	This antibody was purified via Protein A
Storage conditions:	50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA
Excitation Emission:	743nm/767nm
Synonyms:	p66 ShcA
Properties:	C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°
Conjugated:	These antibodies are excite for emission at 650 nm and detected at a 676 nm wavelengths
Gene target:	SHC (Tyr427) Conjugated
Short name:	Conjugated, SHC (Tyr427) Antibody
Technique:	antibodies against human proteins, antibodies for, antibody Conjugates, Antibody
Label:	Cy7
Alternative name:	cyanine 7 coupled, SHC (Tyr427) (Antibody to)
Alternative technique:	antibodies
Identity:	10840
Gene:	SHC1 | More about : SHC1
Long gene name:	SHC adaptor protein 1
Synonyms gene:	SHC
Synonyms gene name:	SHC (Src homology 2 domain-containing) transforming protein 1
Locus:	1q21, 3
Discovery year:	1993-02-17
GenBank acession:	U73377
Entrez gene record:	6464
Pubmed identfication:	1623525
RefSeq identity:	NM_183001
Classification:	SH2 domain containing
Havana BLAST/BLAT:	OTTHUMG00000037295

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