| Long name: |
FITC Conjugated, Rb/P105 RB (Ser807 + Ser811) Antibody |
| Category: |
Conjugated Primary Antibodies |
| Conjugation: |
Anti-FITC Antibody |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
Rb/P105 RB Ser807 + Ser811 |
| Specificity: |
This is a highly specific antibody against Rb/P105 RB Ser807 + Ser811 |
| Modification: |
Phosphorylation |
| Modification site: |
Ser807 + Ser811 |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Source: |
KLH conjugated synthetic phosphopeptide derived from human P105 RB around the phosphorylation site of Ser807/Ser811 |
| Gene ID number: |
5925 |
| Tested applications: |
IF(IHC-P) |
| Recommended dilutions: |
IF(IHC-P)(1:50-200) |
| Crossreactivity: |
Mouse, Rat, Human |
| Crossreactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Antigen background: |
ATF2, Aberrations in the Rb gene have been implicated in cancers of breast, Elf1 and cAbl, It forms a complex with SV40 large T antigen, PU1, Rb is phosphorylated on serine and threonine, Rb protein may act by regulating transcription and loss of its function leads to uncontrolled cell growth, This ability of Rb to alter transcription is regulated by phosphorylation catalyzed by the cyclin dependent protein kinases (cdks), UBF, adenovirus E1A, and human papilloma virus 16E, and leukemia, but not on tyrosine residues, colon, kidney, nasopharynx, prostate, Nuclear MarkerRb is a tumor suppressor gene which functions as a negative regulator of the cell cycle by interacting with transcription factors including E2F1 |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA |
| Excitation Emission: |
494nm/518nm |
| Synonyms: |
LYT-10 p52 p105 NF-kB2 p49/p100 |
| Properties: |
Bioss Primary Conjugated Antibodies FITC is highly sensitive to pH extremes, FITC has a green emission that's usually collected at 530 nanometers, FITC has a high quantum yield (efficiency of energy transfer from absorption to emission fluorescence) and approximately half of the absorbed photons are emitted as fluorescent light, For fluorescent microscopy applications, This Bioss Primary Conjugated Antibodies Fluorescein isothiocyanate (FITC) antibody is currently after some BD antibodies the most commonly used fluorescent dye for FACS, When excited at 488 nanometers, its photo bleaching effects are not observed due to a very brief interaction at the laser intercept, the 1 FITC is seldom used as it photo bleaches rather quickly though in flow cytometry applications, the FL1 detector of a FACSCalibur or FACScan, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
Rb/P105 RB (Ser807 + Ser811) Conjugated |
| Short name: |
FITC Conjugated, Rb/P105 RB (Ser807 + Ser811) Antibody |
| Technique: |
Fluorescein, antibodies against human proteins, antibodies for, antibody Conjugates, Antibody |
| Label: |
FITC |
| Alternative name: |
fluorecein coupled, Rb/P105 RB (Ser807 and Ser811) (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
7795 |
| Gene: |
NFKB2 |
More about : NFKB2 |
| Long gene name: |
nuclear factor kappa B subunit 2 |
| Synonyms gene name: |
nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) |
| Locus: |
10q24, 32 |
| Discovery year: |
1991-11-14 |
| GenBank acession: |
X61498 |
| Entrez gene record: |
4791 |
| Pubmed identfication: |
1876189 |
| Classification: |
Ankyrin repeat domain containing NF-kappa B complex subunits |
| Havana BLAST/BLAT: |
OTTHUMG00000018962 |