| Long name: |
FAK2/PYK2 Primary Polyclonal Antibody |
| Also known as: |
FAK2/PYK2 PAb |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
FAK2/PYK2 |
| Specificity: |
This is a highly specific antibody against FAK2/PYK2 |
| Modification(s): |
None |
| Modification site(s): |
Unmodified antibody |
| Clonality: |
Polyclonal antibody |
| Clone number: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen range: |
20-70/1009 |
| Subcellular location: |
Cell membrane, Nucleus, Cytoplasm |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human FAK2/Pyk2 |
| Gene ID number: |
2185 |
| Swiss Prot: |
Q14289 |
| Tested Applications: |
IF(IHC-P), IHC-P, WB |
| Recommended dilutions: |
IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity: |
Mouse, Rat, Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
'Tyr-373', Acts as a scaffold, Forms multisubunit signaling complexes with SRC and SRC family members upon activation, Functions in signaling downstream of integrin and collagen receptors, G-protein coupled receptors (GPCR), MAPK3/ERK1 and MAPK8/JNK1, May inhibit differentiation and activity of osteoprogenitor cells, P53/TP53 ubiquitination and proteasomal degradation, Plays a role in the regulation of the humoral immune response, Promotes activation of Rho family GTPases, Promotes activation of phosphatidylinositol 3-kinase and of the AKT1 signaling cascade, Promotes activation of the MAP kinase signaling cascade, Promotes osteoclastic bone resorption, Promotes phosphorylation of NMDA receptors by SRC family members, Recruits the ubiquitin ligase MDM2 to P53/TP53 in the nucleus, Regulates cytoskeleton rearrangement and cell spreading in T-cells, Regulates numerous signaling pathways, Regulates production of the cellular messenger cGMP, Required for normal macrophage polarization and migration towards sites of inflammation, adhesion, and 'Tyr-376', and contributes to the regulation of T-cell responses, and is required for normal levels of marginal B-cells in the spleen and normal migration of splenic B-cells, and mediates responses to cellular stress, and thereby contributes to the regulation of NMDA receptor ion channel activity and intracellular Ca(2+) levels, and thereby regulates P53/TP53 activity, binding to both PDPK1 and SRC, cell migration, cell polarization, chemokine and growth factor receptors, creating binding sites for scaffold proteins, cytokine, effectors and substrates, immune receptors, including activation of MAPK1/ERK2, spreading and bone remodeling, such as RHOA and RAC1, thereby allowing SRC to phosphorylate PDPK1 at 'Tyr-9, this leads to the phosphorylation of additional tyrosine residues, this requires both PTK2B/PYK2 and SRC, Non-receptor protein-tyrosine kinase that regulates reorganization of the actin cytoskeleton |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
CADTK, CAK-beta, CAKB, Calcium-dependent tyrosine kinase, Calcium-regulated non-receptor proline-rich tyrosine kinase, Cell adhesion kinase beta, FADK 2, FADK2, FAK2, Focal adhesion kinase 2, PTK, PTK2B, PYK2, Proline-rich tyrosine kinase 2, Protein-tyrosine kinase 2-beta, RAFTK, Related adhesion focal tyrosine kinase, PKB |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
FAK2/PYK2 |
| Short name: |
FAK2/PYK2 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
FAK2/PYK2 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
9612 |
| Gene: |
PTK2B |
More about : PTK2B |
| Long gene name: |
protein tyrosine kinase 2 beta |
| Synonyms gene: |
FAK2 |
| Synonyms gene name: |
protein tyrosine kinase 2 beta PTK2B protein tyrosine kinase 2 beta |
| Synonyms: |
CAKB PYK2 RAFTK PTK CADTK |
| Locus: |
8p21, 2 |
| Discovery year: |
1998-06-22 |
| GenBank acession: |
U33284 |
| Entrez gene record: |
2185 |
| Pubmed identfication: |
7544443 7499242 |
| RefSeq identity: |
NM_004103 |
| Classification: |
Minor histocompatibility antigens FERM domain containing |
| Havana BLAST/BLAT: |
OTTHUMG00000102082 |