| Long name: |
PLK1 (Thr210) Primary Polyclonal Antibody |
| Also known as: |
PLK1 (Thr210) PAb |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
PLK1 Thr210 |
| Specificity: |
This phosphorylation site is homologous across the listed species, This is a highly specific antibody against PLK1 Thr210 |
| Modification(s): |
Phosphorylation |
| Modification site(s): |
Thr210 |
| Clonality: |
Polyclonal antibody |
| Clone number: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen range: |
180-230/603 |
| Subcellular location: |
Nucleus, Cytoplasm |
| Source: |
KLH conjugated synthetic phosphopeptide derived from human PLK1 around the phosphorylation site of Thr210 |
| Gene ID number: |
5347 |
| Swiss Prot: |
P53350 |
| Tested Applications: |
IF(IHC-P), IHC-P, WB |
| Recommended dilutions: |
IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity: |
Mouse, Rat, Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
Contributes to the regulation of AURKA function, NEDD1 phosphorylation promotes subsequent targeting of the gamma-tubulin ring complex (gTuRC) to the centrosome, Phosphorylates BORA, Phosphorylates NEDD1, Phosphorylates SGOL1, Phosphorylates both ECT2 and RACGAP1, Promotes the central spindle recruitment of ECT2, Regulates TP53 stability through phosphorylation of TOPORS, Required for kinetochore localization of BUB1B, Required for recovery after DNA damage checkpoint and entry into mitosis, Required for spindle pole localization of isoform 3 of SGOL1 and plays a role in regulating its centriole cohesion function, an important step for spindle formation, and the regulation of mitotic exit and cytokinesis, and thereby promotes the degradation of BORA, and thereby stimulates their interaction that is essential for the cleavage furrow formation, including the regulation of centrosome maturation and spindle assembly, the inactivation of APC/C inhibitors, the removal of cohesins from chromosome arms, Serine/threonine-protein kinase that performs several important functions throughout M phase of the cell cycle |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
PLK-1, PLK1, Polo-like kinase 1, STPK13, Serine/threonine-protein kinase 13, Serine/threonine-protein kinase PLK1, PLK |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
PLK1 (Thr210) |
| Short name: |
PLK1 (Thr210) Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
PLK1 (Thr210) (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
9077 |
| Gene: |
PLK1 |
More about : PLK1 |
| Long gene name: |
polo like kinase 1 |
| Synonyms gene: |
PLK |
| Synonyms gene name: |
polo-like kinase (Drosophila) polo-like kinase 1 |
| Locus: |
16p12, 2 |
| Discovery year: |
1994-07-25 |
| Entrez gene record: |
5347 |
| Pubmed identfication: |
8127874 |
| RefSeq identity: |
NM_005030 |
| Havana BLAST/BLAT: |
OTTHUMG00000096984 |