| Long name: |
PKC alpha/beta II (Thr638/641) Antibody |
| Also known as: |
PKC alpha/beta II (Thr638/641) Antibody |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
PKC alpha/beta II Thr638/641 |
| Specificity: |
This is a highly specific antibody against PKC alpha/beta II Thr638/641 |
| Modification(s): |
Phosphorylation |
| Modification site(s): |
Thr638/641 |
| Clonality: |
Polyclonal antibody |
| Clone number: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen range: |
606-641/672 |
| Subcellular location: |
Cytoplasm |
| Source: |
KLH conjugated synthetic phosphopeptide derived from human PKC alpha/beta II around the phosphorylation site of Thr638/641 |
| Gene ID number: |
5578 |
| Swiss Prot: |
P17252 |
| Tested Applications: |
IF(IHC-P), IHC-P, WB |
| Recommended dilutions: |
IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity: |
Dog, Mouse, Rat, Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
PKC alpha is an ubiquitously expressed PKC isozyme that has been implicated in the regulation of a broad range of cellular functions including proliferation, The activation loop threonine (threonine 497 in PKC alpha) of conventional PKCs is phosphorylated by phosphoinositide dependent kinase 1 (PDK1), This phosphorylation is necessary for the autophosphorylation of threonine 638 in the carboxy terminus of PKC alpha, a step that is critical for regulating the rate of PKC alpha dephosphorylation and inactivation, and solute transport, cell cell adhesion, cell extracellular matrix adhesion, cell survival and transcriptional regulation, development, diacylglycerol, differentiation, migration, phosphatidylserine and phorbol esters) of the PKC family of serine/ threonine kinases that are involved in a wide range of physiological processes including mitogenesis, Protein Kinase c alpha (PKC alpha) is an 77 kDa member of the conventional group (cPKCs: sensitive to calcium |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
PKC-A, PKC-alpha, PKCA, PRKACA, PRKCA, Protein kinase C alpha type, AAG6 |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
PKC alpha/beta II (Thr638/641) |
| Short name: |
PKC alpha/beta II (Thr638/641) Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
PKC a/b II (Thr638/641) (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
30500 |
| Gene: |
PRRT2 |
More about : PRRT2 |
| Long gene name: |
proline rich transmembrane protein 2 |
| Synonyms gene: |
ICCA DYT10 |
| Synonyms gene name: |
infantile convulsions and paroxysmal choreoathetosis dystonia 10 proline-rich transmembrane protein 2 |
| Synonyms: |
FLJ25513 DKFZp547J199 IFITMD1 FICCA DSPB3 PKC EKD1 |
| Synonyms name: |
interferon induced transmembrane protein domain containing 1 |
| Locus: |
16p11, 2 |
| Discovery year: |
2005-11-25 |
| GenBank acession: |
BC011405 |
| Entrez gene record: |
112476 |
| Pubmed identfication: |
22101681 22243967 |
| RefSeq identity: |
NM_145239 |
| Classification: |
Proline rich transmembrane proteins |
| Havana BLAST/BLAT: |
OTTHUMG00000177142 |