| Long name: |
MYPT1 (Ser668) Primary Polyclonal Antibody |
| Also known as: |
MYPT1 (Ser668) PAb |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
MYPT1 Ser668 |
| Specificity: |
This is a highly specific antibody against MYPT1 Ser668 |
| Modification(s): |
Phosphorylation |
| Modification site(s): |
Ser668 |
| Clonality: |
Polyclonal antibody |
| Clone number: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Source: |
KLH conjugated synthetic phosphopeptide derived from human around the phosphorylation site of Ser668 |
| Gene ID number: |
4659 |
| Tested Applications: |
IF(IHC-P), IHC-P, WB |
| Recommended dilutions: |
IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity: |
Mouse, Rat, Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
Overexpression of RhoA or activated RhoA in NIH 3T3 cells increased phosphorylation of MBS and MLC, Rho associated kinase (Rho kinase), RhoA, The guanosine triphosphate (GTP) bound, The small guanosine triphosphatase Rho is implicated in myosin light chain (MLC) phosphorylation, Therefore Rho appears to inhibit myosin phosphatase through the action of Rho kinase, active form of RhoA (GTP, phosphorylated MBS and consequently inactivated myosin phosphatase, which is activated by GTP, which regulates the extent of phosphorylation of MLC, which results in contraction of smooth muscle and interaction of actin and myosin in non muscle cells, Myosin phosphatase regulates the interaction of actin and myosin downstream of the guanosine triphosphatase Rho, RhoA) specifically interacted with the myosin binding subunit (MBS) of myosin phosphatase |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
M130, MBS, MGC133042, MYPT 1, MYPT1, MYPT1_HUMAN, Myosin Phosphatase, Myosin Phosphatase phospho S668, Myosin Phosphatase phospho Ser668, Myosin phosphatase target subunit 1, Myosin phosphatase targeting subunit 1, Myosin phosphatase-targeting subunit 1, PPP1R12A, Protein phosphatase 1 regulatory inhibitor subunit 12A, Protein phosphatase 1 regulatory subunit 12A, Protein phosphatase myosin binding subunit, Protein phosphatase myosin-binding subunit, p-MYPT1Ser668, MYPT1 Ser668 |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
MYPT1 (Ser668) |
| Short name: |
MYPT1 (Ser668) Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
MYPT1 (Ser668) (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
7618 |
| Gene: |
PPP1R12A |
More about : PPP1R12A |
| Long gene name: |
protein phosphatase 1 regulatory subunit 12A |
| Synonyms gene: |
MYPT1 |
| Synonyms gene name: |
protein phosphatase 1, regulatory (inhibitor) subunit 12A protein phosphatase 1, regulatory subunit 12A |
| Synonyms: |
MBS M130 |
| Synonyms name: |
myosin phosphatase-targeting subunit 1 myosin binding subunit |
| Locus: |
12q21, 2-q21, 31 |
| Discovery year: |
1997-12-23 |
| GenBank acession: |
D87930 |
| Entrez gene record: |
4659 |
| Pubmed identfication: |
9286714 |
| RefSeq identity: |
NM_002480 |
| Classification: |
Ankyrin repeat domain containing Protein phosphatase 1 regulatory subunits |
| Havana BLAST/BLAT: |
OTTHUMG00000170100 |