| Long name: |
MDM2 (Ser166) Primary Polyclonal Antibody |
| Also known as: |
MDM2 (Ser166) PAb |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
MDM2 Ser166 |
| Specificity: |
This is a highly specific antibody against MDM2 Ser166 |
| Modification(s): |
Phosphorylation |
| Modification site(s): |
Ser166 |
| Clonality: |
Polyclonal antibody |
| Clone number: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Source: |
KLH conjugated synthetic phosphopeptide derived from human MDM2 around the phosphorylation site of Ser166 |
| Gene ID number: |
4193 |
| Tested Applications: |
IF(IHC-P), IHC-P, WB |
| Recommended dilutions: |
IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity: |
Mouse, Rat, Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
ARF(P14), Belongs to the MDM2/MDM4 family, Binds p53, Can interact also with retinoblastoma protein(RB), E1A-associated protein EP300 and the E2F1 transcription factor, Forms a ternary complex with TP53/p53 and WWOX, Functions as a ubiquitin ligase E3, Interacts with, Interacts with CDKN2AIP, Interacts with PYHIN1, Isoform Mdm2-F does not interact with TP53/p53, MTBP, Permits the nuclear export of p53 and targets it for proteasome-mediated proteolysis, TRBG1 and USP7, and ubiquitinates HIV-1 Tat, in the presence of E1 and E2, p73, ribosomal protein L5 and specifically to RNA, toward p53 and itself, Inhibits TP53/p53- and TP73/p73-mediated cell cyclearrest and apoptosis by binding its transcriptional activation domain |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
Double minute 2 protein, HDM2, Hdm 2, MDM 2, MDM2 Ser166, MDM2BP, MTBP, Mdm2 transformed 3T3 cell double minute 2 p53 binding protein mouse binding protein 104kDa, Mouse Double Minute 2, Murine Double Minute Chromosome 2, Oncoprotein Mdm2, Ubiquitin protein ligase E3 Mdm2, p53 Binding Protein Mdm2, MDM2Ser166 |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
MDM2 (Ser166) |
| Short name: |
MDM2 (Ser166) Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
MDM2 (Ser166) (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
6973 |
| Gene: |
MDM2 |
More about : MDM2 |
| Long gene name: |
MDM2 proto-oncogene |
| Synonyms gene name: |
E3 ubiquitin protein ligase , human homolog of, mouse double minute 2, p53 binding protein (mouse) Mdm2 p53 binding protein homolog (mouse) MDM2 proto-oncogene, p53-binding protein Mdm2, transformed 3T3 cell double minute 2 |
| Synonyms: |
HDM2 MGC5370 |
| Locus: |
12q15 |
| Discovery year: |
1993-12-10 |
| Entrez gene record: |
4193 |
| Pubmed identfication: |
1614537 16905769 |
| RefSeq identity: |
NM_006880 |
| Classification: |
Zinc fingers RANBP2-type |
| Havana BLAST/BLAT: |
OTTHUMG00000142827 |