| Long name: |
IKK alpha / IKKB (Thr23) Antibody |
| Also known as: |
IKK alpha / IKKB (Thr23) Antibody |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
IKK alpha / IKKB Thr23 |
| Specificity: |
This is a highly specific antibody against IKK alpha / IKKB Thr23 |
| Modification(s): |
Phosphorylation |
| Modification site(s): |
Thr23 |
| Clonality: |
Polyclonal antibody |
| Clone number: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Source: |
KLH conjugated synthetic phosphopeptide derived from mouse IKK alpha around the phosphorylation site of Thr23 |
| Gene ID number: |
1147 |
| Tested Applications: |
IF(IHC-P), IHC-P, WB |
| Recommended dilutions: |
IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity: |
Mouse, Rat, Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
Acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B on serine residues, Additionally, As part of the non-canonical pathway of NF-kappa-B activation, CHUK plays a key role in the negative feedback of NF-kappa-B canonical signaling to limit inflammatory gene activation, DNA damages or other cellular stresses, In turn, In turn, Modulates chromatin accessibility at NF-kappa-B-responsive promoters by phosphorylating histones H3 at 'Ser-10' that are subsequently acetylated at 'Lys-14' by CREBBP, Negatively regulates the pathway by phosphorylating the scaffold protein TAXBP1 and thus promoting the assembly of the A20/TNFAIP3 ubiquitin-editing complex (composed of A20/TNFAIP3, Participates also in the negative feedback of the non-canonical NF-kappa-B signaling pathway by phosphorylating and destabilizing MAP3K14/NIK, TAX1BP1, Therefore, These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome, Within the nucleus, and the E3 ligases ITCH and RNF11), bacterial or viral products, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, inducing its proteolytic processing to NFKB2/p52 and the formation of NF-kappa-B RelB-p52 complexes, or protection against apoptosis, phosphorylates CREBBP and consequently increases both its transcriptional and histone acetyltransferase activities, phosphorylates the CREBBP-interacting protein NCOA3, the MAP3K14-activated CHUK/IKKA homodimer phosphorylates NFKB2/p100 associated with RelB, these complexes regulate genes encoding molecules involved in B-cell survival and lymphoid organogenesis, Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
CHUK, Conserved helix-loop-helix ubiquitous kinase, I-kappa-B kinase 1, I-kappa-B kinase alpha, IKK-A, IKK-alpha, IKK1, IKKA, IkBKA, IkappaB kinase, NFKBIKA, Nuclear factor NF-kappa-B inhibitor kinase alpha, TCF-16, TCF16, Transcription factor 16, Inhibitor of nuclear factor kappa-B kinase subunit alpha |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
IKK alpha / IKKB (Thr23) |
| Short name: |
IKK alpha / IKKB (Thr23) Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
IKK a / IKKB (Thr23) (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
5960 |
| Gene: |
IKBKB |
More about : IKBKB |
| Long gene name: |
inhibitor of nuclear factor kappa B kinase subunit beta |
| Synonyms gene name: |
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta |
| Synonyms: |
IKK2 NFKBIKB IKK-beta IKKB |
| Locus: |
8p11, 21 |
| Discovery year: |
1998-02-11 |
| GenBank acession: |
AF029684 |
| Entrez gene record: |
3551 |
| Pubmed identfication: |
9878263 9763654 18308615 |
| Havana BLAST/BLAT: |
OTTHUMG00000164092 |