| Long name: |
Recombinant Human Gremlin-1 (GREM1) |
| Alternative names: |
BMP antagonist 1, BMP antagonist 1, Cell proliferation-inducing gene 2 protein, Cysteine knot superfamily 1, DAN domain family member 2, DAN domain family member 2, DAN family BMP antagonist, Down-regulated in Mos-transformed cells protein, Gremlin-1, IHG-2, Increased in high glucose protein 2, cell proliferation-inducing gene 2 protein, colorectal adenoma and carcinoma 1, cysteine knot superfamily, cysteine knot superfamily 1, down-regulated in Mos-transformed cells protein, gremlin 1, gremlin 1, gremlin 1-like protein, gremlin-1, homolog, increased in high glucose-2, gremlin-1 isoform 2 |
| Gene name: |
GREM1 |
| Other gene names: |
CKTSF1B1, CKTSF1B1, CRAC1, DAND2, DAND2, DRM, DRM, GREM1, GREMLIN, HMPS, IHG-2, IHG-2, PIG2, GREM1 |
| General description: |
All of our recombinant proteins are manufactured in strictly controlled facilities and by using a well established technology which guarantees full batch-to-bact consistency and experiment reproducibility, The protein can be with or without a His-Tag or other tag in accordance to customer's request, Gremlin-1 (GREM1) is a recombinant protein expressed in Mammalian Cell |
| Product category: |
Recombinant Proteins |
| Expression system: |
Mammalian Cell |
| Available also expressed in:: |
Baculovirus , Mammalian Cell, Yeast , E Coli |
| Purity: |
Greater than 90% (determined by SDS-PAGE) |
| Form: |
Lyophilized protein |
| Storage: |
Avoid cycles of freezing and thawing as they might denaturate the polypeptide chains, For extended periods of time it is recommended to keep the protein frozen at -40 or -80 degrees Celsius, This protein can be stored at -20 degrees Celsius |
| Applications: |
IFA, RIA, Western Blot, etc, This protein can be used as a positive control for applications such as ELISA |
| Properties: |
Depending on the epitopes used human ELISA kits can be cross reactive to many other species, Mainly analyzed are human serum, Modern , cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies, human cell culture supernatants and biological samples, plasma, primarily , saliva, urine, , (Homo sapiens, Homo sapiens sapiens), Human proteins, humans , ssp |
| Gene target: |
Gremlin-1 (GREM1) |
| Short name: |
Gremlin-1 (GREM1) |
| Species: |
Humans, Human |
| Alternative name: |
sapiens Gremlin-1 (gremlin 1), H |
| Alternative to gene target: |
DNA-templated and biological process this GO :0045893 and positive regulation of transcription, DNA-templated and biological process this GO :0045944 and positive regulation of transcription from RNA polymerase II promoter and biological process this GO :0046851 and negative regulation of bone remodeling and biological process this GO :0048018 and receptor a this GO nist activity and molecular function this GO :0048263 and determination of dorsal identity and biological process this GO :0051092 and positive regulation of NF-kappaB transcription factor activity and biological process this GO :0051893 and regulation of focal adhesion assembly and biological process this GO :0051973 and positive regulation of telomerase activity and biological process this GO :0060394 and negative regulation of pathway-restricted SMAD protein phosphorylation and biological process this GO :0060676 and ureteric bud formation and biological process this GO :0061098 and positive regulation of protein tyrosine kinase activity and biological process this GO :0090027 and negative regulation of monocyte chemotaxis and biological process this GO :0090090 and negative regulation of canonical Wnt signaling pathway and biological process this GO :0090190 and positive regulation of branching involved in ureteric bud morphogenesis and biological process this GO :0090191 and negative regulation of branching involved in ureteric bud morphogenesis and biological process this GO :0090291 and negative regulation of osteoclast proliferation and biological process this GO :1900086 and positive regulation of peptidyl-tyrosine autophosphorylation and biological process this GO :1900155 and negative regulation of bone trabecula formation and biological process this GO :1900158 and negative regulation of bone mineralization involved in bone maturation and biological process this GO :2000273 and positive regulation of receptor activity and biological process this GO :2000727 and positive regulation of cardiac muscle cell differentiation and biological process, Extracellular, GREM1 and IDBG-5193 and ENSG00000166923 and 26585, GREM1 and IDBG-648566 and ENSBTAG00000046604 and 539079, Grem1 and IDBG-197200 and ENSMUSG00000074934 and 23892, receptor a this GO nist activity, this GO :0000902 and cell morphogenesis and biological process this GO :0001525 and angiogenesis and biological process this GO :0001658 and branching involved in ureteric bud morphogenesis and biological process this GO :0002042 and cell migration involved in sprouting angiogenesis and biological process this GO :0002092 and positive regulation of receptor internalization and biological process this GO :0002689 and negative regulation of leukocyte chemotaxis and biological process this GO :0003257 and positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation and biological process this GO :0003337 and mesenchymal to epithelial transition involved in metanephros morphogenesis and biological process this GO :0005125 and cytokine activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005615 and extracellular space and cellular component this GO :0006915 and apoptotic process and biological process this GO :0007165 and signal transduction and biological process this GO :0007171 and activation of transmembrane receptor protein tyrosine kinase activity and biological process this GO :0007267 and cell-cell signaling and biological process this GO :0008284 and positive regulation of cell proliferation and biological process this GO :0009887 and organ morphogenesis and biological process this GO :0009954 and proximal/distal pattern formation and biological process this GO :0009986 and cell surface and cellular component this GO :0010717 and regulation of epithelial to mesenchymal transition and biological process this GO :0016015 and morphogen activity and molecular function this GO :0030199 and collagen fibril organization and biological process this GO :0030297 and transmembrane receptor protein tyrosine kinase activator activity and molecular function this GO :0030308 and negative regulation of cell growth and biological process this GO :0030326 and embryonic limb morphogenesis and biological process this GO :0030502 and negative regulation of bone mineralization and biological process this GO :0030514 and negative regulation of BMP signaling pathway and biological process this GO :0033689 and negative regulation of osteoblast proliferation and biological process this GO :0036122 and BMP binding and molecular function this GO :0042346 and positive regulation of NF-kappaB import into nucleus and biological process this GO :0043184 and vascular endothelial growth factor receptor 2 binding and molecular function this GO :0043542 and endothelial cell migration and biological process this GO :0045766 and positive regulation of angiogenesis and biological process this GO :0045892 and negative regulation of transcription, this GO :0005125 : cytokine activity, this GO :0005125 : cytokine activity and also this GO :0005515 : protein binding and also this GO :0016015 : morphogen activity and also this GO :0030297 : transmembrane receptor protein tyrosine kinase activator activity and also this GO :0036122 : BMP binding and also this GO :0043184 : vascular endothelial growth factor receptor 2 binding and also this GO :0048018 : receptor a this GO nist activity, this GO :0005515 : protein binding, this GO :0016015 : morphogen activity, this GO :0030297 : transmembrane receptor protein tyrosine kinase activator activity, this GO :0036122 : BMP binding, this GO :0043184 : vascular endothelial growth factor receptor 2 binding, this GO :0048018 : receptor a this GO nist activity, gremlin 1 |
| Identity: |
2001 |
| Gene: |
GREM1 |
More about : GREM1 |
| Long gene name: |
DAN family BMP antagonist , gremlin 1 |
| Synonyms gene: |
CKTSF1B1 CRAC1 |
| Synonyms gene name: |
BMP antagonist 1 gremlin 1, cysteine knot superfamily, cysteine knot superfamily 1, homolog (Xenopus laevis) gremlin 1 colorectal adenoma and carcinoma 1 |
| Synonyms: |
DRM gremlin DAND2 HMPS |
| Locus: |
15q13, 3 |
| Discovery year: |
1999-12-02 |
| Entrez gene record: |
26585 |
| Pubmed identfication: |
9660951 10026205 22561515 27385727 |
| RefSeq identity: |
NM_013372 |
| Classification: |
DAN family |
| Havana BLAST/BLAT: |
OTTHUMG00000129319 |