| Long name: |
FLT3 (Tyr842) Primary Polyclonal Antibody |
| Also known as: |
FLT3 (Tyr842) PAb |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
FLT3 Tyr842 |
| Specificity: |
This is a highly specific antibody against FLT3 Tyr842 |
| Modification(s): |
Phosphorylation |
| Modification site(s): |
Tyr842 |
| Clonality: |
Polyclonal antibody |
| Clone number: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen range: |
820-870/993 |
| Subcellular location: |
Cytoplasm |
| Source: |
KLH conjugated synthetic phosphopeptide derived from human FLT3 around the phosphorylation site of Tyr842 |
| Gene ID number: |
2322 |
| Swiss Prot: |
P36888 |
| Tested Applications: |
IF(IHC-P), IHC-P, WB |
| Recommended dilutions: |
IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity: |
Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
Activation of wild-type FLT3 causes only marginal activation of STAT5A or STAT5B, FER, Mutations that cause constitutive kinase activity promote cell proliferation and resistance to apoptosis via the activation of multiple signaling pathways, PLCG1, PTPN11/SHP-2, PTPN6/SHP, Promotes activation of RAS signaling and phosphorylation of downstream kinases, Promotes phosphorylation of FES, Promotes phosphorylation of SHC1 and AKT1, and STAT5A and/or STAT5B, and activation of the downstream effector MTOR, including MAPK1/ERK2 and/or MAPK3/ERK1, proliferation and survival of hematopoietic progenitor cells and of dendritic cells, Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine FLT3LG and regulates differentiation |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
CD135, FL cytokine receptor, FLK-2, FLT-3, FLT3, Fetal liver kinase-2, Fms-like tyrosine kinase 3, Receptor-type tyrosine-protein kinase FLT3, STK-1, STK1, Stem cell tyrosine kinase 1, FLK2 |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
FLT3 (Tyr842) |
| Short name: |
FLT3 (Tyr842) Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
fms-related tyrosine kinase 3 (Tyr842) (Antibody to) |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
BT, CD135 and FLK-2 and FLK2 and STK1, FLT3 and IDBG-19891 and ENSG00000122025 and 2322, Flt3 and IDBG-209045 and ENSMUSG00000042817 and 14255, nuclei, this GO :0001776 and leukocyte homeostasis and biological process this GO :0001934 and positive regulation of protein phosphorylation and biological process this GO :0002318 and myeloid progenitor cell differentiation and biological process this GO :0002320 and lymphoid progenitor cell differentiation and biological process this GO :0002328 and pro-B cell differentiation and biological process this GO :0002572 and pro-T cell differentiation and biological process this GO :0004672 and protein kinase activity and molecular function this GO :0004713 and protein tyrosine kinase activity and molecular function this GO :0004714 and transmembrane receptor protein tyrosine kinase activity and molecular function this GO :0004896 and cytokine receptor activity and molecular function this GO :0005021 and vascular endothelial growth factor-activated receptor activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005524 and ATP binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0005788 and endoplasmic reticulum lumen and cellular component this GO :0005829 and cytosol and cellular component this GO :0005886 and plasma membrane and cellular component this GO :0005887 and integral component of plasma membrane and cellular component this GO :0006468 and protein phosphorylation and biological process this GO :0007169 and transmembrane receptor protein tyrosine kinase signaling pathway and biological process this GO :0008284 and positive regulation of cell proliferation and biological process this GO :0008285 and negative regulation of cell proliferation and biological process this GO :0009897 and external side of plasma membrane and cellular component this GO :0009986 and cell surface and cellular component this GO :0010243 and response to organonitrogen compound and biological process this GO :0014068 and positive regulation of phosphatidylinositol 3-kinase signaling and biological process this GO :0016020 and membrane and cellular component this GO :0016021 and integral component of membrane and cellular component this GO :0016772 and transferase activity, this GO :0004672 : protein kinase activity, this GO :0004672 : protein kinase activity and also this GO :0004713 : protein tyrosine kinase activity and also this GO :0004714 : transmembrane receptor protein tyrosine kinase activity and also this GO :0004896 : cytokine receptor activity and also this GO :0005021 : vascular endothelial growth factor-activated receptor activity and also this GO :0005515 : protein binding and also this GO :0005524 : ATP binding and also this GO :0016772 : transferase activity, this GO :0004713 : protein tyrosine kinase activity, this GO :0004714 : transmembrane receptor protein tyrosine kinase activity, this GO :0004896 : cytokine receptor activity, this GO :0005021 : vascular endothelial growth factor-activated receptor activity, this GO :0005515 : protein binding, this GO :0005524 : ATP binding, this GO :0016772 : transferase activity, this GO :0032403 : protein complex binding, this GO :0035259 : glucocorticoid receptor binding, this GO :0042803 : protein homodimerization activity, this GO :0043548 : phosphatidylinositol 3-kinase binding, transferase activity, transferring phosphorus-containing groups, transferring phosphorus-containing groups and also this GO :0032403 : protein complex binding and also this GO :0035259 : glucocorticoid receptor binding and also this GO :0042803 : protein homodimerization activity and also this GO :0043548 : phosphatidylinositol 3-kinase binding, transferring phosphorus-containing groups and molecular function this GO :0018108 and peptidyl-tyrosine phosphorylation and biological process this GO :0019221 and cytokine-mediated signaling pathway and biological process this GO :0030097 and hemopoiesis and biological process this GO :0030098 and lymphocyte differentiation and biological process this GO :0030183 and B cell differentiation and biological process this GO :0031100 and organ regeneration and biological process this GO :0032403 and protein complex binding and molecular function this GO :0035259 and glucocorticoid receptor binding and molecular function this GO :0035726 and common myeloid progenitor cell proliferation and biological process this GO :0038084 and vascular endothelial growth factor signaling pathway and biological process this GO :0042531 and positive regulation of tyrosine phosphorylation of STAT protein and biological process this GO :0042803 and protein homodimerization activity and molecular function this GO :0042981 and regulation of apoptotic process and biological process this GO :0043234 and protein complex and cellular component this GO :0043406 and positive regulation of MAP kinase activity and biological process this GO :0043410 and positive regulation of MAPK cascade and biological process this GO :0043548 and phosphatidylinositol 3-kinase binding and molecular function this GO :0043552 and positive regulation of phosphatidylinositol 3-kinase activity and biological process this GO :0045578 and negative regulation of B cell differentiation and biological process this GO :0046651 and lymphocyte proliferation and biological process this GO :0046777 and protein autophosphorylation and biological process this GO :0071345 and cellular response to cytokine stimulus and biological process this GO :0071385 and cellular response to glucocorticoid stimulus and biological process this GO :0097028 and dendritic cell differentiation and biological process, 28173 and IDBG-630678 and ENSBTAG00000018572 and 512700, fms-related tyrosine kinase 3 |
| Identity: |
3765 |
| Gene: |
FLT3 |
More about : FLT3 |
| Long gene name: |
fms related tyrosine kinase 3 |
| Synonyms gene name: |
fms-related tyrosine kinase 3 |
| Synonyms: |
STK1 FLK2 CD135 |
| Locus: |
13q12, 2 |
| Discovery year: |
1990-07-30 |
| GenBank acession: |
U02687 |
| Entrez gene record: |
2322 |
| Pubmed identfication: |
8394751 |
| Classification: |
CD molecules Immunoglobulin like domain containing Receptor Tyrosine Kinases |
| Havana BLAST/BLAT: |
OTTHUMG00000016646 |
| Locus Specific Databases: |
LRG_457 |