| Long name: |
FoxO1 (Ser319) Primary Polyclonal Antibody |
| Also known as: |
FoxO1 (Ser319) PAb |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
FoxO1 Ser319 |
| Specificity: |
Ser313 in rat, This phosphorylation site is found at Ser316 in mouse, This is a highly specific antibody against FoxO1 Ser319 |
| Modification(s): |
Phosphorylation |
| Modification site(s): |
Ser319 |
| Clonality: |
Polyclonal antibody |
| Clone number: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen range: |
315-325/655 |
| Subcellular location: |
Nucleus, Cytoplasm |
| Source: |
KLH conjugated synthetic phosphopeptide derived from human FoxO1 around the phosphorylation site of Ser319 [TS(p-S)NA] |
| Gene ID number: |
2308 |
| Swiss Prot: |
Q12778 |
| Tested Applications: |
IF(IHC-P), IHC-P, WB |
| Recommended dilutions: |
IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity: |
Mouse, Rat, Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
Activity suppressed by insulin, Acts synergistically with ATF4 to suppress osteocalcin/BGLAP activity, Also suppresses the transcriptional activity of RUNX2, Binds to the insulin response element (IRE) with consensus sequence 5'-TT[G/A]TTTTG-3' and the related Daf-16 family binding element (DBE) with consensus sequence 5'-TT[G/A]TTTAC-3', G6PC and PCK1, Important regulator of cell death acting downstream of CDK1, In hepatocytes, Main regulator of redox balance and osteoblast numbers and controls bone mass, Mediates insulin action on adipose tissue, Orchestrates the endocrine function of the skeleton in regulating glucose metabolism, PKB/AKT1 and SKT4/MST1, Promotes neural cell death, Regulates the expression of adipogenic genes such as PPARG during preadipocyte differentiation and, Regulates the transcriptional activity of GADD45A and repair of nitric oxide-damaged DNA in beta-cells, Required for the autophagic cell death induction in response to starvation or oxidative stress in a transcription-independent manner, adipocyte size and adipose tissue-specific gene expression in response to excessive calorie intake, an upstream activator of osteocalcin/BGLAP, increasing glucose levels and triggering glucose intolerance and insulin insensitivity, promotes gluconeogenesis by acting together with PPARGC1A and CEBPA to activate the expression of genes such as IGFBP1, Transcription factor that is the main target of insulin signaling and regulates metabolic homeostasis in response to oxidative stress |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
FKHR, FOXO1, FOXO1A, Forkhead box protein O1, Forkhead box protein O1A, Forkhead in rhabdomyosarcoma, FKH1 |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
FoxO1 (Ser319) |
| Short name: |
FoxO1 (Ser319) Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
forkhead box O1 (Ser319) (Antibody to) |
| Alternative technique: |
antibodies |