| Long name: |
EphA2 (Tyr594) Primary Polyclonal Antibody |
| Also known as: |
EphA2 (Tyr594) PAb |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
EphA2 Tyr594 |
| Specificity: |
Due to the highly conserved nature of this protein to EphA4 and EphA5, This phosphorylation site is homologous to Tyr595 in Mouse and Rat, Tyr495 in Mouse, and Tyr658 in Rat, mu, rt) and EphA5 when phosphorylated at Tyr656 in Human, this antibody may react with these EphA4 when phosphorylated at Tyr602 (hu, This is a highly specific antibody against EphA2 Tyr594 |
| Modification(s): |
Phosphorylation |
| Modification site(s): |
Tyr594 |
| Clonality: |
Polyclonal antibody |
| Clone number: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen range: |
570-610/976 |
| Subcellular location: |
Cytoplasm |
| Source: |
KLH conjugated synthetic phosphopeptide derived from human EphA2 around the phosphorylation site of Tyr594 |
| Gene ID number: |
1969 |
| Swiss Prot: |
P29317 |
| Tested Applications: |
IF(IHC-P), IHC-P, WB |
| Recommended dilutions: |
IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity: |
Mouse, Rat, Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
Activated by the ligand ephrin-A1/EFNA1 regulates migration, During development, Engaged by the ligand ephrin-A5/EFNA5 may regulate lens fiber cells shape and interactions and be important for lens transparency development and maintenance, Involved for instance in angiogenesis, May also participate in UV radiation-induced apoptosis and have a ligand-independent stimulatory effect on chemotactic cell migration, Regulates cell adhesion and differentiation through DSG1/desmoglein-1 and inhibition of the ERK1/ERK2 (MAPK3/MAPK1, The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling, With ephrin-A2/EFNA2 may play a role in bone remodeling through regulation of osteoclastogenesis and osteoblastogenesis, in early hindbrain development and epithelial proliferation and branching morphogenesis during mammary gland development, integrin-mediated adhesion, leading to contact-dependent bidirectional signaling into neighboring cells, may function in distinctive aspects of pattern formation and subsequently in development of several fetal tissues, proliferation and differentiation of cells, respectively) signaling pathway, Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
ARCC2, CTPA, CTPP1, CTRCT6, EPHA2, Ephrin type-A receptor 2, Epithelial cell kinase, Tyrosine-protein kinase receptor ECK, ECK |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
EphA2 (Tyr594) |
| Short name: |
EphA2 (Tyr594) Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
EPH receptor A2 (Tyr594) (Antibody to) |
| Alternative technique: |
antibodies |