| Long name: |
HRP Conjugated, ALK (Y1278 + Y1282 + Y1283) Antibody |
| Category: |
Conjugated Primary Antibodies |
| Conjugation: |
HRP Conjugated |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
ALK Tyr1278 + Tyr1282 + Tyr1283 |
| Specificity: |
This is a highly specific antibody against ALK Tyr1278 + Tyr1282 + Tyr1283 |
| Modification: |
Phosphorylation |
| Modification site: |
Tyr1278 + Tyr1282 + Tyr1283 |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen_range: |
1250-1290/1620 |
| Subcellular location: |
Cytoplasm |
| Source: |
KLH conjugated synthetic phosphopeptide derived from human ALK around the phosphorylation site of Tyr1278/1282/1283 |
| Gene ID number: |
238 |
| Swiss Prot: |
Q9UM73 |
| Tested applications: |
IHC-P, WB |
| Recommended dilutions: |
IHC-P(1:100-500), WB(1:100-1000) |
| Crossreactivity: |
Human |
| Crossreactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Antigen background: |
ALK induces tyrosine phosphorylation of CBL, Acts as a receptor for ligands pleiotrophin (PTN), Drives NF-kappa-B activation, FRS2, Following activation by ligand, IRS1 and SHC1, MDK-binding induces phosphorylation of the ALK target insulin receptor substrate (IRS1), PTN-binding induces MAPK pathway activation, Phosphorylates almost exclusively at the first tyrosine of the Y-x-x-x-Y-Y motif, Recruitment of IRS1 to activated ALK and the activation of NF-kappa-B are essential for the autocrine growth and survival signaling of MDK, Transduces signals from ligands at the cell surface, a PTN-related factor, a secreted growth factor, activates mitogen-activated protein kinases (MAPKs) and PI3-kinase, and midkine (MDK), as well as of the MAP kinases MAPK1/ERK2 and MAPK3/ERK1, probably through IRS1 and the activation of the AKT serine/threonine kinase, resulting also in cell proliferation induction, through specific activation of the mitogen-activated protein kinase (MAPK) pathway, thus participating in PTN and MDK signal transduction, which is important for the anti-apoptotic signaling of PTN and regulation of cell proliferation, Neuronal orphan receptor tyrosine kinase that is essentially and transiently expressed in specific regions of the central and peripheral nervous systems and plays an important role in the genesis and differentiation of the nervous system |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% Gentamicin, Keep the antibody in an aqueous buffered solution containing 1% BSA |
| Synonyms: |
CD246 |
| Properties: |
Also monoclonal HRP conjugates are often used for Western Blot, HRP conjugates are often primary rabbit polyclonal antibodies couples to the , found in the roots of , (HRP), C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°, enzyme , horseradish, horseradish peroxidase |
| Gene target: |
ALK (Y1278 + Y1282 + Y1283) Conjugated |
| Short name: |
Conjugated, ALK (Y1278 + Y1282 + Y1283) Antibody |
| Technique: |
antibodies against human proteins, antibodies for, antibody Conjugates, Antibody |
| Label: |
HRP |
| Alternative name: |
horseradish peroxidase coupled, anaplastic lymphoma receptor tyrosine kinase (Y1278 and Y1282 and Y1283) (Antibody to) |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
ALK and IDBG-42084 and ENSG00000171094 and 238, ALK and IDBG-636042 and ENSBTAG00000007379 and 536642, Alk and IDBG-197259 and ENSMUSG00000055471 and 11682, CD246 and NBLST3, Plasma membranes, this GO :0000187 and activation of MAPK activity and biological process this GO :0004672 and protein kinase activity and molecular function this GO :0004704 and NF-kappaB-inducing kinase activity and molecular function this GO :0004713 and protein tyrosine kinase activity and molecular function this GO :0004714 and transmembrane receptor protein tyrosine kinase activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005524 and ATP binding and molecular function this GO :0005887 and integral component of plasma membrane and cellular component this GO :0006468 and protein phosphorylation and biological process this GO :0007165 and signal transduction and biological process this GO :0007169 and transmembrane receptor protein tyrosine kinase signaling pathway and biological process this GO :0007399 and nervous system development and biological process this GO :0008283 and cell proliferation and biological process this GO :0016020 and membrane and cellular component this GO :0016310 and phosphorylation and biological process this GO :0016772 and transferase activity, this GO :0004672 : protein kinase activity, this GO :0004672 : protein kinase activity and also this GO :0004704 : NF-kappaB-inducing kinase activity and also this GO :0004713 : protein tyrosine kinase activity and also this GO :0004714 : transmembrane receptor protein tyrosine kinase activity and also this GO :0005515 : protein binding and also this GO :0005524 : ATP binding and also this GO :0016772 : transferase activity, this GO :0004704 : NF-kappaB-inducing kinase activity, this GO :0004713 : protein tyrosine kinase activity, this GO :0004714 : transmembrane receptor protein tyrosine kinase activity, this GO :0005515 : protein binding, this GO :0005524 : ATP binding, this GO :0016772 : transferase activity, transferase activity, transferring phosphorus-containing groups, transferring phosphorus-containing groups, transferring phosphorus-containing groups and molecular function this GO :0018108 and peptidyl-tyrosine phosphorylation and biological process this GO :0038061 and NIK/NF-kappaB signaling and biological process this GO :0042981 and regulation of apoptotic process and biological process this GO :0043234 and protein complex and cellular component this GO :0046777 and protein autophosphorylation and biological process this GO :0048666 and neuron development and biological process this GO :0051092 and positive regulation of NF-kappaB transcription factor activity and biological process this GO :0070062 and extracellular vesicular exosome and cellular component, anaplastic lymphoma receptor tyrosine kinase |
| Identity: |
427 |
| Gene: |
ALK |
More about : ALK |
| Long gene name: |
anaplastic lymphoma receptor tyrosine kinase |
| Synonyms gene name: |
anaplastic lymphoma kinase (Ki-1) |
| Locus: |
2p23, 1 , 2-p23 |
| Discovery year: |
1993-08-24 |
| GenBank acession: |
D45915 |
| Entrez gene record: |
238 |
| Pubmed identfication: |
8122112 |
| RefSeq identity: |
NM_004304 |
| Classification: |
CD molecules Receptor Tyrosine Kinases |
| Havana BLAST/BLAT: |
OTTHUMG00000152034 |
| Locus Specific Databases: |
LRG_488 |