MSK1/2 Antibody, FITC Conjugated

Catalog number:	bs-2995R-FITC Buy Now
Price:	350 €
Supplier:	Bioss Primary Conjugated Antibodies
Product name:	MSK1/2 Antibody, FITC Conjugated
Quantity:	0.1ml
Related search:	msk antibody kinase conjugated protein gene ser fluorescent phosphorylation

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Long name:	FITC Conjugated, MSK1/2 Polyclonal Antibody
Category:	Conjugated Primary Antibodies
Conjugation:	Anti-FITC Antibody
Host Organism:	Rabbit (Oryctolagus cuniculus)
Target Antigen:	MSK1/2
Specificity:	This is a highly specific antibody against MSK1/2
Modification:	Unmodified
Modification site:	None
Clonality:	Polyclonal
Clone:	Polyclonal antibody
Concentration:	1ug per 1ul
Immunogen_range:	49-94/802
Subcellular location:	Nucleus
Source:	KLH conjugated synthetic peptide derived from human MSK1
Gene ID number:	8986, 9252
Tested applications:	IF(IHC-P)
Recommended dilutions:	IF(IHC-P)(1:50-200)
Crossreactivity:	Mouse, Rat, Human
Crossreactive species details:	not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Antigen background:	ATF1 H3 and HMG14 in response to mitogen and stress, Functions probably by inducing transcription of the MAP kinase phosphatase DUSP1 and the anti-inflammatory cytokine interleukin 10 (IL10), In lipopolysaccharide-stimulated primary macrophages, It is also known to be required for the phosphorylation of CREB, MSK1 autophosphorylate on at least 5 sites, MSK1 can be activated by ERK1/2 and SAPK2/p38 MAP kinase, MSK1 contains two kinase domains (N term and a C term), MSK2 plays an essential role in the control of RELA transcriptional activity in response to TNF, May also phosphorylate 'Ser-28' of histone H3, Mediates the mitogen- and stress-induced phosphorylation of high mobility group protein 1 (HMGN1/HMG14), Of these autophosphorylation sites Ser212 and Ser376 get phosphorylated by the C terminal kinase domain of MSK1 which is essential for the catalytic activity of the N terminal kinase domain, Once phosphorylated on Thr581 and Ser360 by ERK1/2 and SAPK2/p38, Phosphorylates 'Ser-10' of histone H3 in response to mitogenics, Similar to RSK, acts downstream of the Toll-like receptor TLR4 to limit the production of pro-inflammatory cytokines, including proto-oncogenes c-fos/FOS and c-jun/JUN, stress stimuli and EGF, via CREB1 and ATF1 transcription factors, which results in the transcriptional activation of several immediate early genes, MSK1 is a mitogen and stress activated protein kinase 1 which belongs to the AGC family of kinases and is related in structure to the ribosomal p70 S6 kinase subfamily
Purification method:	This antibody was purified via Protein A
Storage conditions:	50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA
Excitation Emission:	494nm/518nm
Synonyms:	MSK1 RLPK
Properties:	Bioss Primary Conjugated Antibodies FITC is highly sensitive to pH extremes, FITC has a green emission that's usually collected at 530 nanometers, FITC has a high quantum yield (efficiency of energy transfer from absorption to emission fluorescence) and approximately half of the absorbed photons are emitted as fluorescent light, For fluorescent microscopy applications, This Bioss Primary Conjugated Antibodies Fluorescein isothiocyanate (FITC) antibody is currently after some BD antibodies the most commonly used fluorescent dye for FACS, When excited at 488 nanometers, its photo bleaching effects are not observed due to a very brief interaction at the laser intercept, the 1 FITC is seldom used as it photo bleaches rather quickly though in flow cytometry applications, the FL1 detector of a FACSCalibur or FACScan, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°
Gene target:	MSK1/2 Conjugated
Short name:	FITC Conjugated, MSK1/2 Antibody
Technique:	Fluorescein, antibodies against human proteins, antibodies for, antibody Conjugates, Antibody
Label:	FITC
Alternative name:	fluorecein coupled, MSK1/2 (Antibody to)
Alternative technique:	antibodies
Identity:	10434
Gene:	RPS6KA5 | More about : RPS6KA5
Long gene name:	ribosomal protein S6 kinase A5
Synonyms gene name:	90kD, polypeptide 5 , ribosomal protein S6 kinase
Locus:	14q32, 11
Discovery year:	1999-03-10
GenBank acession:	AF074393
Entrez gene record:	9252
Pubmed identfication:	9687510 10702687
RefSeq identity:	NM_004755
Classification:	Mitogen-activated protein kinase-activated protein kinases
Havana BLAST/BLAT:	OTTHUMG00000171055

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