| Long name: |
SQSTM1 Primary Polyclonal Antibody |
| Also known as: |
SQSTM1 PAb |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
SQSTM1 |
| Specificity: |
This is a highly specific antibody against SQSTM1 |
| Modification(s): |
None |
| Modification site(s): |
Unmodified antibody |
| Clonality: |
Polyclonal antibody |
| Clone number: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen range: |
80-130/440 |
| Subcellular location: |
Nucleus, Cytoplasm |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human SQSTM1/Ubiquitin-binding protein p62 |
| Gene ID number: |
8878 |
| Swiss Prot: |
Q13501 |
| Tested Applications: |
IF(IHC-P), IHC-P, WB |
| Recommended dilutions: |
IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity: |
Mouse, Rat, Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
Adapter that mediates the interaction between TRAF6 and CYLD (By similarity), Involved in midbody ring degradation, May be involved in cell differentiation, May play a role in titin/TTN downstream signaling in muscle cells, May regulate signaling cascades through ubiquitination, May regulate the activation of NFKB1 by TNF-alpha, Required both for the formation and autophagic degradation of polyubiquitin-containing bodies, apoptosis, called ALIS (aggresome-like induced structures) and links ALIS to the autophagic machinery, immune response and regulation of K(+) channels, nerve growth factor (NGF) and interleukin-1, Autophagy receptor that interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
A170, EBI3-associated protein of 60 kDa, EBIAP, ORCA, OSIL, PDB3, Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa, SQSTM1, Sequestosome-1, Ubiquitin-binding protein p62, ZIP3, p62, p62B, p60 |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
SQSTM1 |
| Short name: |
SQSTM1 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
sequestosome 1 (Antibody to) |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
A170 and OSIL and p60 and p62 and p62B and PDB3 and ZIP3, BT, K63-linked polyubiquitin binding, SQSTM1 and IDBG-61811 and ENSG00000161011 and 8878, Sqstm1 and IDBG-168358 and ENSMUSG00000015837 and 18412, nuclei, this GO :0000407 and pre-autopha this GO somal structure and cellular component this GO :0000932 and cytoplasmic mRNA processing body and cellular component this GO :0001934 and positive regulation of protein phosphorylation and biological process this GO :0002376 and immune system process and biological process this GO :0004674 and protein serine/threonine kinase activity and molecular function this GO :0005080 and protein kinase C binding and molecular function this GO :0005515 and protein binding and molecular function this GO :0005654 and nucleoplasm and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0005764 and lysosome and cellular component this GO :0005770 and late endosome and cellular component this GO :0005776 and autophagic vacuole and cellular component this GO :0005783 and endoplasmic reticulum and cellular component this GO :0005829 and cytosol and cellular component this GO :0006468 and protein phosphorylation and biological process this GO :0006511 and ubiquitin-dependent protein catabolic process and biological process this GO :0006914 and autophagy and biological process this GO :0006950 and response to stress and biological process this GO :0008104 and protein localization and biological process this GO :0008270 and zinc ion binding and molecular function this GO :0016197 and endosomal transport and biological process this GO :0016234 and inclusion body and cellular component this GO :0016235 and aggresome and cellular component this GO :0016236 and macroautophagy and biological process this GO :0016239 and positive regulation of macroautophagy and biological process this GO :0016605 and PML body and cellular component this GO :0019901 and protein kinase binding and molecular function this GO :0030154 and cell differentiation and biological process this GO :0030971 and receptor tyrosine kinase binding and molecular function this GO :0031410 and cytoplasmic vesicle and cellular component this GO :0035556 and intracellular signal transduction and biological process this GO :0042169 and SH2 domain binding and molecular function this GO :0042802 and identical protein binding and molecular function this GO :0042803 and protein homodimerization activity and molecular function this GO :0043065 and positive regulation of apoptotic process and biological process this GO :0043066 and negative regulation of apoptotic process and biological process this GO :0043122 and regulation of I-kappaB kinase/NF-kappaB signaling and biological process this GO :0043130 and ubiquitin binding and molecular function this GO :0045087 and innate immune response and biological process this GO :0045944 and positive regulation of transcription from RNA polymerase II promoter and biological process this GO :0046578 and regulation of Ras protein signal transduction and biological process this GO :0048011 and neurotrophin TRK receptor signaling pathway and biological process this GO :0051291 and protein heterooli this GO merization and biological process this GO :0070062 and extracellular vesicular exosome and cellular component this GO :0070530 and K63-linked polyubiquitin binding and molecular function this GO :0097190 and apoptotic signaling pathway and biological process, this GO :0004674 : protein serine/threonine kinase activity, this GO :0004674 : protein serine/threonine kinase activity and also this GO :0005080 : protein kinase C binding and also this GO :0005515 : protein binding and also this GO :0008270 : zinc ion binding and also this GO :0019901 : protein kinase binding and also this GO :0030971 : receptor tyrosine kinase binding and also this GO :0042169 : SH2 domain binding and also this GO :0042802 : identical protein binding and also this GO :0042803 : protein homodimerization activity and also this GO :0043130 : ubiquitin binding and also this GO :0070530 : K63-linked polyubiquitin binding, this GO :0005080 : protein kinase C binding, this GO :0005515 : protein binding, this GO :0008270 : zinc ion binding, this GO :0019901 : protein kinase binding, this GO :0030971 : receptor tyrosine kinase binding, this GO :0042169 : SH2 domain binding, this GO :0042802 : identical protein binding, this GO :0042803 : protein homodimerization activity, this GO :0043130 : ubiquitin binding, this GO :0070530 : K63-linked polyubiquitin binding, 105440 and IDBG-640935 and ENSBTAG00000015591 and 338045, sequestosome 1 |
| Identity: |
11280 |
| Gene: |
SQSTM1 |
More about : SQSTM1 |
| Long gene name: |
sequestosome 1 |
| Synonyms gene: |
PDB3 OSIL |
| Synonyms gene name: |
Paget disease of bone 3 oxidative stress induced like |
| Synonyms: |
p62 p60 p62B A170 |
| Locus: |
5q35, 3 |
| Discovery year: |
2000-06-13 |
| GenBank acession: |
U46751 |
| Entrez gene record: |
8878 |
| Pubmed identfication: |
8650207 8551575 |
| Classification: |
Zinc fingers ZZ-type |
| Havana BLAST/BLAT: |
OTTHUMG00000150643 |