| Long name: |
Jak3 Primary Polyclonal Antibody |
| Also known as: |
Jak3 PAb |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
Jak3 |
| Specificity: |
This has 85% sequence similarity with JAK1 and may cross-react, This is a highly specific antibody against Jak3 |
| Modification(s): |
None |
| Modification site(s): |
Unmodified antibody |
| Clonality: |
Polyclonal antibody |
| Clone number: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen range: |
610-660/1124 |
| Subcellular location: |
Cytoplasm |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human Jak3 |
| Gene ID number: |
3718 |
| Swiss Prot: |
P52333 |
| Tested Applications: |
IF(IHC-P), IHC-P, WB |
| Recommended dilutions: |
IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity: |
Mouse, Rat, Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
Following ligand binding to cell surface receptors, For example, IL15R and IL21R, IL4R, IL7R, IL9R, In the cytoplasm, JAK1 and JAK3 molecules bind to IL2R beta (IL2RB) and gamma chain (IL2RG) subunits inducing the tyrosine phosphorylation of both receptor subunits on their cytoplasmic domain, Mediates essential signaling events in both innate and adaptive immunity and plays a crucial role in hematopoiesis during T-cells development, Once activated, Phosphorylated STATs then form homodimer or heterodimers and translocate to the nucleus to activate gene transcription, STAT5A AND STAT5B are recruited, Subsequently, Then, creating docking sites for STATs proteins, development, dimerized STAT5 translocates to the nucleus and promotes the transcription of specific target genes in a cytokine-specific fashion, or differentiation, phosphorylated and activated by JAK1 and JAK3, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, phosphorylates the STATs proteins once they are recruited to the receptor, plays a pivotal role in signal transduction via its association with type I receptors sharing the common subunit gamma such as IL2R, upon IL2R activation by IL2, Non-receptor tyrosine kinase involved in various processes such as cell growth |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
JAK-3, JAK3, JAK3_HUMAN, Janus kinase 3, L-JAK, LJAK, Leukocyte janus kinase, Tyrosine-protein kinase JAK3, JAKL |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
Jak3 |
| Short name: |
Jak3 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
Janus kinase 3 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
6193 |
| Gene: |
JAK3 |
More about : JAK3 |
| Long gene name: |
Janus kinase 3 |
| Synonyms: |
L-JAK JAKL LJAK JAK3_HUMAN JAK-3 |
| Synonyms name: |
tyrosine-protein kinase JAK3 leukocyte Janus kinase |
| Locus: |
19p13, 11 |
| Discovery year: |
1994-12-19 |
| GenBank acession: |
U31601 |
| Entrez gene record: |
3718 |
| Pubmed identfication: |
8921370 9226382 |
| RefSeq identity: |
NM_000215 |
| Havana BLAST/BLAT: |
OTTHUMG00000165648 |
| Locus Specific Databases: |
JAK3base: Mutation registry for autosomal recessive severe combined JAK3 deficiency LRG_77 |