| Long name: |
ALEXA FLUOR 555 Conjugated, TNFAIP3 Polyclonal Antibody |
| Also known as: |
Anti-TNFAIP3 PAb ALEXA FLUOR 555 |
| Category: |
Conjugated Primary Antibodies |
| Conjugated with: |
555, ALEXA FLUOR® |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
TNFAIP3 |
| Specificity: |
This is a highly specific antibody against TNFAIP3 |
| Modification: |
Unmodified |
| Modification Site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen range: |
80-103/790 |
| Subcellular location: |
Lysosome, Nucleus, Cytoplasm |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human TNFAIP3 |
| Gene ID Number: |
7128 |
| Swiss Prot: |
P21580 |
| Tested applications: |
IF(IHC-P) |
| Recommended dilutions: |
IF(IHC-P)(1:50-200) |
| Crossreactivity: |
Mouse, Rat, Human |
| Cross-reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the antigen: |
'Lys-48'- and 'Lys-63' polyubiquitin chains, Can also inhibit I-kappa-B-kinase (IKK) through a non-catalytic mechanism which involves polyubiquitin, Deubiquitinates NEMO/IKBKG, Deubiquitinates TRAF6 probably acting on 'Lys-63'-linked polyubiquitin, Essential component of a ubiquitin-editing protein complex, ITCH and TAX1BP1, In cooperation with TAX1BP1 promotes disassembly of E2-E3 ubiquitin protein ligase complexes in IL-1R and TNFR-1 pathways, In cooperation with TAX1BP1 promotes ubiquitination of UBE2N and proteasomal degradation of UBE2N and UBE2D3, In vitro able to deubiquitinate 'Lys-11'-, Inhibitor of programmed cell death, Involved in immune and inflammatory responses signaled by cytokines, TRAF2 and BIRC2, Targets TRAF2 for lysosomal degradation, This leads to RIPK1 proteasomal degradation and consequently termination of the TNF- or LPS-mediated activation of NF-kappa-B, Upon T-cell receptor (TCR)-mediated T-cell activation, Upon TNF stimulation, Upon stimulation by bacterial peptidoglycans, affected are at least E3 ligases TRAF6, and E2 ubiquitin-conjugating enzymes UBE2N and UBE2D3, comprising also RNF11, deubiquitinates 'Lys-63'-polyubiquitin chains on MALT1 thereby mediating disassociation of the CBM (CARD11:BCL10:MALT1) and IKK complexes and preventing sustained IKK activation, deubiquitinates 'Lys-63'-polyubiquitin chains on RIPK1 and catalyzes the formation of 'Lys-48'-polyubiquitin chains, or pathogens via Toll-like receptors (TLRs) through terminating NF-kappa-B activity, polyubiquitin promotes association with IKBKG and prevents IKK MAP3K7-mediated phosphorylation, probably deubiquitinates RIPK2, such as TNF-alpha and IL-1 beta, that ensures the transient nature of inflammatory signaling pathways, the function is facilitated by TNIP1 and leads to inhibition of NF-kappa-B activation, Ubiquitin-editing enzyme that contains both ubiquitin ligase and deubiquitinase activities |
| Purification: |
Purified by Protein A |
| Storage conditions: |
50% glycerol and 0, Keep refrigerated at 2 to 8 degrees Celcius for up to one year, 09% sodium azide, Store this antibody in aqueous buffered solution containing 1% BSA |
| Excitation emission: |
553nm/568nm |
| Synonyms: |
A20 OTUD7C |
| Properties: |
ALEXA FLUOR they should be stored frozen at - 24°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies, Very high photo stable ALEXA conjugate, C, C for long term storage and for short term at + 5°, For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
ALEXA FLUOR 555, Alexa Fluor |
| Gene target: |
TNFAIP3 |
| Short name: |
TNFAIP3 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Label: |
ALEXA FLUOR 555 |
| Alternative name: |
ALEXA FLUOR 555, a-induced protein 3 (Antibody to), tumor necrosis factor |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
A20 and OTUD7C and TNFA1P2, TNFAIP3 and IDBG-633691 and ENSBTAG00000000436 and 508105, TNFAIP3 and IDBG-97033 and ENSG00000118503 and 7128, Tnfaip3 and IDBG-135792 and ENSMUSG00000019850 and 21929, alpha-induced protein 3, leucine rich repeat containing receptor signaling pathway and biological process this GO :0043124 and negative regulation of I-kappaB kinase/NF-kappaB signaling and biological process this GO :0043130 and ubiquitin binding and molecular function this GO :0043621 and protein self-association and molecular function this GO :0045087 and innate immune response and biological process this GO :0045732 and positive regulation of protein catabolic process and biological process this GO :0045736 and negative regulation of cyclin-dependent protein serine/threonine kinase activity and biological process this GO :0045779 and negative regulation of bone resorption and biological process this GO :0045824 and negative regulation of innate immune response and biological process this GO :0048662 and negative regulation of smooth muscle cell proliferation and biological process this GO :0050691 and regulation of defense response to virus by host and biological process this GO :0050728 and negative regulation of inflammatory response and biological process this GO :0050869 and negative regulation of B cell activation and biological process this GO :0051259 and protein oli this GO merization and biological process this GO :0060548 and negative regulation of cell death and biological process this GO :0061043 and regulation of vascular wound healing and biological process this GO :0070062 and extracellular vesicular exosome and cellular component this GO :0070301 and cellular response to hydrogen peroxide and biological process this GO :0070423 and nucleotide-binding oli this GO merization domain containing signaling pathway and biological process this GO :0070429 and negative regulation of nucleotide-binding oli this GO merization domain containing 1 signaling pathway and biological process this GO :0070433 and negative regulation of nucleotide-binding oli this GO merization domain containing 2 signaling pathway and biological process this GO :0070536 and protein K63-linked deubiquitination and biological process this GO :0070936 and protein K48-linked ubiquitination and biological process this GO :0071108 and protein K48-linked deubiquitination and biological process this GO :0071222 and cellular response to lipopolysaccharide and biological process this GO :0072573 and tolerance induction to lipopolysaccharide and biological process this GO :0090291 and negative regulation of osteoclast proliferation and biological process this GO :1902042 and negative regulation of extrinsic apoptotic signaling pathway via death domain receptors and biological process this GO :2000347 and positive regulation of hepatocyte proliferation and biological process this GO :2000349 and negative regulation of CD40 signaling pathway and biological process this GO :2000352 and negative regulation of endothelial cell apoptotic process and biological process, nuclei, protein self-association, this GO :0001922 and B-1 B cell homeostasis and biological process this GO :0002020 and protease binding and molecular function this GO :0002237 and response to molecule of bacterial origin and biological process this GO :0002634 and regulation of germinal center formation and biological process this GO :0002677 and negative regulation of chronic inflammatory response and biological process this GO :0003677 and DNA binding and molecular function this GO :0004221 and ubiquitin thiolesterase activity and molecular function this GO :0004842 and ubiquitin-protein transferase activity and molecular function this GO :0004843 and ubiquitin-specific protease activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0005764 and lysosome and cellular component this GO :0005813 and centrosome and cellular component this GO :0005829 and cytosol and cellular component this GO :0006508 and proteolysis and biological process this GO :0006915 and apoptotic process and biological process this GO :0006954 and inflammatory response and biological process this GO :0008270 and zinc ion binding and molecular function this GO :0016579 and protein deubiquitination and biological process this GO :0016874 and ligase activity and molecular function this GO :0019900 and kinase binding and molecular function this GO :0031397 and negative regulation of protein ubiquitination and biological process this GO :0032088 and negative regulation of NF-kappaB transcription factor activity and biological process this GO :0032480 and negative regulation of type I interferon production and biological process this GO :0032495 and response to muramyl dipeptide and biological process this GO :0032691 and negative regulation of interleukin-1 beta production and biological process this GO :0032703 and negative regulation of interleukin-2 production and biological process this GO :0032715 and negative regulation of interleukin-6 production and biological process this GO :0032720 and negative regulation of tumor necrosis factor production and biological process this GO :0034136 and negative regulation of toll-like receptor 2 signaling pathway and biological process this GO :0034140 and negative regulation of toll-like receptor 3 signaling pathway and biological process this GO :0034144 and negative regulation of toll-like receptor 4 signaling pathway and biological process this GO :0034148 and negative regulation of toll-like receptor 5 signaling pathway and biological process this GO :0035871 and protein K11-linked deubiquitination and biological process this GO :0035872 and nucleotide-binding domain, this GO :0002020 : protease binding, this GO :0002020 : protease binding and also this GO :0003677 : DNA binding and also this GO :0004221 : ubiquitin thiolesterase activity and also this GO :0004842 : ubiquitin-protein transferase activity and also this GO :0004843 : ubiquitin-specific protease activity and also this GO :0005515 : protein binding and also this GO :0008270 : zinc ion binding and also this GO :0016874 : ligase activity and also this GO :0019900 : kinase binding and also this GO :0043130 : ubiquitin binding and also this GO :0043621 : protein self-association, this GO :0003677 : DNA binding, this GO :0004221 : ubiquitin thiolesterase activity, this GO :0004842 : ubiquitin-protein transferase activity, this GO :0004843 : ubiquitin-specific protease activity, this GO :0005515 : protein binding, this GO :0008270 : zinc ion binding, this GO :0016874 : ligase activity, this GO :0019900 : kinase binding, this GO :0043130 : ubiquitin binding, this GO :0043621 : protein self-association, tumor necrosis factor |
| Identity: |
11896 |
| Gene: |
TNFAIP3 |
More about : TNFAIP3 |
| Long gene name: |
TNF alpha induced protein 3 |
| Synonyms gene name: |
alpha-induced protein 3 , tumor necrosis factor |
| Locus: |
6q23, 3 |
| Discovery year: |
1992-10-20 |
| GenBank acession: |
M59465 |
| Entrez gene record: |
7128 |
| Pubmed identfication: |
2118515 |
| Classification: |
OTU domain containing |
| Havana BLAST/BLAT: |
OTTHUMG00000015664 |