| Long name: |
TREML2 Primary Polyclonal Antibody |
| Also known as: |
TREML2 PAb |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
TREML2 |
| Specificity: |
This is a highly specific antibody against TREML2 |
| Modification(s): |
None |
| Modification site(s): |
Unmodified antibody |
| Clonality: |
Polyclonal antibody |
| Clone number: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Subcellular location: |
Extracellular |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human TREML2 |
| Gene ID number: |
79865 |
| Tested Applications: |
IF(IHC-P), IHC-P, WB |
| Recommended dilutions: |
IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity: |
Mouse, Rat, Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
It is a cell surface receptor that may play a role in the innate and adaptive immune response, Monocytes in the bone marrow or peripheral blood do not express detectable levels of TREML2, TREML2 does not exhibit any of the features associated with classical tyrosine-based signaling, TREML2 is expressed on B lineage cells early in development, TREML2 is located in a gene cluster on chromosome 6 with the single Ig variable (IgV) domain activating receptors TREM1 and TREM2, TREML2 is present on neutrophils in the bone marrow as well as the periphery, TREML2 is unique in that it lacks either the conserved transmembrane lysine residue or ITAM/ITIMs within its own cytoplasmic domain, Thus, and inflammatory stimuli result in a dramatic increase in the expression of TREML2 on these cells in vivo, and it contains 1 Ig-like V-type (immunoglobulin-like) domain, and the highest level of expression is detected on those mature peripheral B cell subpopulations that are involved in the initial humoral immune response against bacterial pathogens, but it has distinct structural and functional properties, but its expression is up-regulated in conjunction with differentiation into macrophages, TREML2 is a single-pass type I membrane protein, TREML2 is expressed throughout B cell development in addition to being expressed on macrophages and neutrophils and is the only TREM molecule to be found on lymphocytes |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
Chromosome 6 open reading frame 76, FLJ13693, MGC149715, MGC149716, TLT 2, TLT2, TREM like transcript 2, TRML2_HUMAN, Trem like transcript 2 protein, Triggering receptor expressed on myeloid cells like 2, Triggering receptor expressed on myeloid cells like protein 2, C6orf76 |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
TREML2 |
| Short name: |
TREML2 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
triggering receptor expressed on myeloid cells-like 2 (Antibody to) |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
Cell surfaces, TREML2 and IDBG-630865 and ENSBTAG00000015707 and 515548, TREML2 and IDBG-86610 and ENSG00000112195 and 79865, Treml2 and IDBG-189835 and ENSMUSG00000071068 and 328833, protein binding, this GO :0004872 and receptor activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005886 and plasma membrane and cellular component this GO :0009986 and cell surface and cellular component this GO :0016021 and integral component of membrane and cellular component this GO :0042110 and T cell activation and biological process this GO :0045087 and innate immune response and biological process, this GO :0004872 : receptor activity, this GO :0004872 : receptor activity and also this GO :0005515 : protein binding, this GO :0005515 : protein binding, triggering receptor expressed on myeloid cells-like 2 |
| Identity: |
21092 |
| Gene: |
TREML2 |
More about : TREML2 |
| Long gene name: |
triggering receptor expressed on myeloid cells like 2 |
| Synonyms gene: |
C6orf76 |
| Synonyms gene name: |
chromosome 6 open reading frame 76 triggering receptor expressed on myeloid cells-like 2 |
| Synonyms: |
FLJ13693 TLT2 dJ238O23, 1 |
| Synonyms name: |
TREM-like transcript 2 |
| Locus: |
6p21, 1 |
| Discovery year: |
2003-05-19 |
| GenBank acession: |
AK023755 |
| Entrez gene record: |
79865 |
| Pubmed identfication: |
12645956 |
| RefSeq identity: |
NM_024807 |
| Classification: |
V-set domain containing |
| Havana BLAST/BLAT: |
OTTHUMG00000016349 |