| Long name: |
CRLF2 Primary Polyclonal Antibody |
| Also known as: |
CRLF2 PAb |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
CRLF2 |
| Specificity: |
This is a highly specific antibody against CRLF2 |
| Modification(s): |
None |
| Modification site(s): |
Unmodified antibody |
| Clonality: |
Polyclonal antibody |
| Clone number: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Subcellular location: |
Extracellular |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human CRLF2 |
| Gene ID number: |
64109 |
| Tested Applications: |
IF(IHC-P), IHC-P, WB |
| Recommended dilutions: |
IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity: |
Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
Expression has also been reported in heart, Ligand receptor interactions haves been implicated in the development of the hematopoietic system, STAT3 and STAT5 to stimulate cell proliferation, TSLP binding to the heterodimeric functional receptor (TSLPR and IL7R) activates JAK2, TSLPR has a predicted molecular weight approximately 41 kD, The TSLP R contains a WSXWS motif required for proper protein folding and a box1 motif important for association with the JAKs, The TSLPR is expressed preferentially in myeloid cells including dendritic cells and activated monocytes, and is weakly expressed in T cells, and kidney tissues, and the maintenance and polarization of human Th2 memory T cells in allergic diseases, and two further isoforms have been reported that are produced by alternative splicing, dendritic cell maturation, skeletal muscle, TSLPR is a type I membrane receptor that forms a functional heterodimeric complex with IL7R to bind TSLP |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
CRL 2, CRL2, CRLF 2, CRLF2, CRLF2Y, Cytokine receptor CRL2 precusor, Cytokine receptor like 2, Cytokine receptor like factor 2, Cytokine receptor like factor 2 precursor, IL XR, ILXR, TSLP receptor, TSLPR, Thymic stromal derived lymphopoietin receptor, Thymic stromal lymphopoietin protein receptor, Thymic stromal lymphopoietin receptor, TSLPR |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
CRLF2 |
| Short name: |
CRLF2 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
cytokine receptor-like factor 2 (Antibody to) |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
CRLF2 and IDBG-39359 and ENSG00000205755 and 64109, CRLF2 and IDBG-645338 and ENSBTAG00000020242 and 529792, Crlf2 and IDBG-188983 and ENSMUSG00000033467 and 57914, Extracellular, protein binding, this GO :0002380 and immunoglobulin secretion involved in immune response and biological process this GO :0005515 and protein binding and molecular function this GO :0005576 and extracellular region and cellular component this GO :0005886 and plasma membrane and cellular component this GO :0006954 and inflammatory response and biological process this GO :0016021 and integral component of membrane and cellular component this GO :0035745 and T-helper 2 cell cytokine production and biological process, this GO :0005515 : protein binding, this GO :0005515 : protein binding, cytokine receptor-like factor 2 |
| Identity: |
14281 |
| Gene: |
CRLF2 |
More about : CRLF2 |
| Long gene name: |
cytokine receptor-like factor 2 |
| Synonyms: |
CRL2 TSLPR |
| Locus: |
Xp22, 3 , 3 and Yp11 |
| Discovery year: |
2001-02-06 |
| GenBank acession: |
AF142570 |
| Entrez gene record: |
64109 |
| Pubmed identfication: |
11237741 11474172 |
| RefSeq identity: |
NM_022148 |
| Classification: |
Fibronectin type III domain containing Pseudoautosomal region 1 |
| Havana BLAST/BLAT: |
OTTHUMG00000067432 |