| Long name: |
Aconitase 2/ACO2 Primary Polyclonal Antibody |
| Also known as: |
Aconitase 2/ACO2 PAb |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
Aconitase 2/ACO2 |
| Specificity: |
This is a highly specific antibody against Aconitase 2/ACO2 |
| Modification(s): |
None |
| Modification site(s): |
Unmodified antibody |
| Clonality: |
Polyclonal antibody |
| Clone number: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human Aconitase 2 |
| Gene ID number: |
50 |
| Tested Applications: |
IF(IHC-P), IHC-P, WB |
| Recommended dilutions: |
IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity: |
Mouse, Rat, Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
ACO2 activity is dependent on the state of this cluster as well as the presence of two conserved cysteine residues, ACO2 contains a redox-sensitive iron-sulfur cluster that exists in two states: active (Fe4S4) and inactive (Fe3S4), In malignant prostate cells zinc is unable to accumulate, In normal prostate epithelial cells ACO2 activity is prevented due to the high levels of zinc inhibiting the enzyme, In these citrate-producing epithelial cells citrate oxidation is impaired allowing citrate to accumulate and exhibit a citrate:isocitrate ratio of approximately 30:1, It is expressed in the mitochondria and maintains a citrate:isocitrate ratio of approximately 10:1, also referred to as aconitate hydratase, citrate hydrolyase or aconitase, is an iron-sulfur hydrolyase that catalyzes the non-limiting interconversion of citrate and isocitrate in the tricarboxylic acid cycle, therefore ACO2 activity resumes and citrate is oxidized, ACO2 |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
ACO2, ACONM, Aconitase, Aconitase 2 mitochondrial, Aconitase2, Aconitate hydratase, Aconitate hydratase mitochondrial, Citrate hydro lyase, aconitase 2, ACO 2 |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
Aconitase 2/ACO2 |
| Short name: |
Aconitase 2/ACO2 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
Aconitase 2/ACO2 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
118 |
| Gene: |
ACO2 |
More about : ACO2 |
| Long gene name: |
aconitase 2 |
| Synonyms gene name: |
aconitase 2, mitochondrial |
| Synonyms: |
ACONM |
| Synonyms name: |
aconitate hydratase, mitochondrial mitochondrial aconitase |
| Locus: |
22q13, 2 |
| Discovery year: |
1986-01-01 |
| GenBank acession: |
AH006514 |
| Entrez gene record: |
50 |
| Pubmed identfication: |
10591208 |
| RefSeq identity: |
NM_001098 |
| Havana BLAST/BLAT: |
OTTHUMG00000030544 |