| Long name: |
PI3KCA Primary Polyclonal Antibody |
| Also known as: |
PI3KCA PAb |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
PI3KCA |
| Specificity: |
This is a highly specific antibody against PI3KCA |
| Modification(s): |
None |
| Modification site(s): |
Unmodified antibody |
| Clonality: |
Polyclonal antibody |
| Clone number: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen range: |
1010-1050/1068 |
| Subcellular location: |
Membrane bound, Cytoplasm |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human PI3KCA |
| Gene ID number: |
5290 |
| Swiss Prot: |
P42336 |
| Tested Applications: |
FCM, IF(IHC-P), IHC-P, WB |
| Recommended dilutions: |
FCM(1:20-100), IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity: |
Mouse, Rat, Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
EIF4EBP1 and HRAS, Essential in endothelial cell migration during vascular development through VEGFA signaling, Has also serine-protein kinase activity: phosphorylates PIK3R1 (p85alpha regulatory subunit), IGF1, Involved in signaling via insulin-receptor substrate (IRS) proteins, Involved in the activation of AKT1 upon stimulation by receptor tyrosine kinases ligands such as EGF, PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, Participates in cardiomyogenesis in embryonic stem cells through a AKT1 pathway, Participates in cellular signaling in response to various growth factors, Participates in vasculogenesis in embryonic stem cells through PDK1 and protein kinase C pathway, PtdIns4P (Phosphatidylinositol 4-phosphate) and PtdIns(4, Regulates invadopodia formation in breast cancer cells through the PDPK1-AKT1 pathway, Required for lymphatic vasculature development, VEGFA and PDGF, activating signaling cascades involved in cell growth, but not by PDGF, including AKT1 and PDPK1, insulin, motility and morphology, possibly by binding to RAS and by activation by EGF and FGF2, possibly by regulating RhoA activity, proliferation, survival, 4, 5)P2 (Phosphatidylinositol 4, 5-bisphosphate) to generate phosphatidylinositol 3, 5-trisphosphate (PIP3), Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns (Phosphatidylinositol) |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
CLOVE, CWS5, MCAP, MCMTC, PI3-kinase subunit alpha, PI3K, PI3K-alpha, PI3Kalpha, PIK3CA, Phosphatidylinositol 4, Phosphatidylinositol 4, Phosphoinositide-3-kinase catalytic alpha polypeptide, PtdIns-3-kinase subunit alpha, PtdIns-3-kinase subunit p11-alpha, Serine/threonine protein kinase PIK3CA, p11-alpha, p11alpha, 5-bisphosphate 3-kinase 11 kDa catalytic subunit alpha, 5-bisphosphate 3-kinase catalytic subunit alpha isoform, MCM |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
PI3KCA |
| Short name: |
PI3KCA Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
PI3KCA (Antibody to) |
| Alternative technique: |
antibodies |