| Long name: |
ALEXA FLUOR 647 Conjugated, DAXX Polyclonal Antibody |
| Also known as: |
Anti-DAXX PAb ALEXA FLUOR 647 |
| Category: |
Conjugated Primary Antibodies |
| Conjugated with: |
647, ALEXA FLUOR® |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
DAXX |
| Specificity: |
This is a highly specific antibody against DAXX |
| Modification: |
Unmodified |
| Modification Site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human DAXX |
| Gene ID Number: |
1616 |
| Tested applications: |
IF(IHC-P) |
| Recommended dilutions: |
IF(IHC-P)(1:50-200) |
| Crossreactivity: |
Mouse, Rat, Human |
| Cross-reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the antigen: |
Down-regulates basal and activated transcription, In contrast, Interaction with HSPB1/HSP27 may prevent interaction with TNFRSF6 and MAP3K5 and block DAXX-mediated apoptosis, Its transcription repressor activity is modulated by recruiting it to subnuclear compartments like the nucleolus or PML/POD/ND10 nuclear bodies through interactions with MCSR1 and PML, MDM2 degradation, Modulates PAX5 activity, Proposed to mediate activation of the JNK pathway and apoptosis via MAP3K5 in response to signaling from TNFRSF6 and TGFBR2, Seems to act as a transcriptional corepressor and inhibits PAX3 and ETS1 through direct protein-protein interaction, Seems to regulate transcription in PML/POD/ND10 nuclear bodies together with PML and may influence TNFRSF6-dependent apoptosis thereby, Under non-stress condition, Upon DNA damage, in association with the deubiquitinating USP7, in lymphoid cells JNC activation and TNFRSF6-mediated apoptosis may not involve DAXX, its association with MDM2 and USP7 is disrupted, prevents MDM2 self-ubiquitination and enhances the intrinsic E3 ligase activity of MDM2 towards TP53, respectively, resulting in increased MDM2 autoubiquitination and consequently, thereby promoting TP53 ubiquitination and subsequent proteasomal degradation, which leads to TP53 stabilization, Acts as an adapter protein in a MDM2-DAXX-USP7 complex by regulating the RING-finger E3 ligase MDM2 ubiquitination activity |
| Purification: |
Purified by Protein A |
| Storage conditions: |
50% glycerol and 0, Keep refrigerated at 2 to 8 degrees Celcius for up to one year, 09% sodium azide, Store this antibody in aqueous buffered solution containing 1% BSA |
| Excitation emission: |
650nm/665nm |
| Synonyms: |
DAP6 |
| Properties: |
ALEXA FLUOR made this Alexa Fluor 633 conjugate that can be used in multi-color flow cytometry with instruments equipped with a second red laser or red diode, ALEXA FLUOR they should be stored frozen at - 24°, Alexa Fluor 633 is a practical alternative to APC as well as Cy5, Bioss Primary Conjugated Antibodies, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies, It is detected in the FL4 detector of the core's upgraded 2-laser FACScans, Like other Alexa Fluor dyes, exhibits uncommon photo stability, making it an ideal choice for fluorescent microscopy, the DAXX Antibody, C, C for long term storage and for short term at + 5°, For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
ALEXA FLUOR 647, Alexa Fluor |
| Gene target: |
DAXX |
| Short name: |
DAXX Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Label: |
ALEXA FLUOR 647 |
| Alternative name: |
ALEXA FLUOR 647, death-domain associated protein (Antibody to) |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
BING2 and DAP6 and EAP1, DAXX and IDBG-629026 and ENSBTAG00000016830 and 504336, DAXX and IDBG-82726 and ENSG00000204209 and 102723452, DNA-templated and biological process this GO :0006355 and regulation of transcription, DNA-templated and biological process this GO :0006915 and apoptotic process and biological process this GO :0007257 and activation of JUN kinase activity and biological process this GO :0008134 and transcription factor binding and molecular function this GO :0008625 and extrinsic apoptotic signaling pathway via death domain receptors and biological process this GO :0016032 and viral process and biological process this GO :0016605 and PML body and cellular component this GO :0019899 and enzyme binding and molecular function this GO :0019901 and protein kinase binding and molecular function this GO :0030295 and protein kinase activator activity and molecular function this GO :0030521 and androgen receptor signaling pathway and biological process this GO :0031072 and heat shock protein binding and molecular function this GO :0031396 and regulation of protein ubiquitination and biological process this GO :0031625 and ubiquitin protein ligase binding and molecular function this GO :0042393 and histone binding and molecular function this GO :0042803 and protein homodimerization activity and molecular function this GO :0045860 and positive regulation of protein kinase activity and biological process this GO :0045892 and negative regulation of transcription, DNA-templated and biological process this GO :0047485 and protein N-terminus binding and molecular function this GO :0050681 and androgen receptor binding and molecular function this GO :0070603 and SWI/SNF superfamily-type complex and cellular component this GO :0097190 and apoptotic signaling pathway and biological process this GO :1901216 and positive regulation of neuron death and biological process this GO :2001235 and positive regulation of apoptotic signaling pathway and biological process, Daxx and IDBG-168138 and ENSMUSG00000002307 and 13163, androgen receptor binding, centromeric region and cellular component this GO :0000792 and heterochromatin and cellular component this GO :0001934 and positive regulation of protein phosphorylation and biological process this GO :0002039 and p53 binding and molecular function this GO :0003714 and transcription corepressor activity and molecular function this GO :0005057 and receptor signaling protein activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005730 and nucleolus and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0005829 and cytosol and cellular component this GO :0006334 and nucleosome assembly and biological process this GO :0006338 and chromatin remodeling and biological process this GO :0006351 and transcription, nuclei, this GO :0000281 and mitotic cytokinesis and biological process this GO :0000775 and chromosome, this GO :0002039 : p53 binding, this GO :0002039 : p53 binding and also this GO :0003714 : transcription corepressor activity and also this GO :0005057 : receptor signaling protein activity and also this GO :0005515 : protein binding and also this GO :0008134 : transcription factor binding and also this GO :0019899 : enzyme binding and also this GO :0019901 : protein kinase binding and also this GO :0030295 : protein kinase activator activity and also this GO :0031072 : heat shock protein binding and also this GO :0031625 : ubiquitin protein ligase binding and also this GO :0042393 : histone binding and also this GO :0042803 : protein homodimerization activity and also this GO :0047485 : protein N-terminus binding and also this GO :0050681 : androgen receptor binding, this GO :0003714 : transcription corepressor activity, this GO :0005057 : receptor signaling protein activity, this GO :0005515 : protein binding, this GO :0008134 : transcription factor binding, this GO :0019899 : enzyme binding, this GO :0019901 : protein kinase binding, this GO :0030295 : protein kinase activator activity, this GO :0031072 : heat shock protein binding, this GO :0031625 : ubiquitin protein ligase binding, this GO :0042393 : histone binding, this GO :0042803 : protein homodimerization activity, this GO :0047485 : protein N-terminus binding, this GO :0050681 : androgen receptor binding, 1616, death-domain associated protein |
| Identity: |
2681 |
| Gene: |
DAXX |
More about : DAXX |
| Long gene name: |
death domain associated protein |
| Synonyms gene name: |
death-associated protein 6 |
| Locus: |
6p21, 32 |
| Discovery year: |
1998-03-25 |
| GenBank acession: |
AF006041 |
| Entrez gene record: |
1616 |
| Pubmed identfication: |
9407001 9215629 |
| Havana BLAST/BLAT: |
OTTHUMG00000031203 |