| Long name: |
FITC Conjugated, ABI1 Polyclonal Antibody |
| Category: |
Conjugated Primary Antibodies |
| Conjugation: |
Anti-FITC Antibody |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
ABI1 |
| Specificity: |
This is a highly specific antibody against ABI1 |
| Modification: |
Unmodified |
| Modification site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen_range: |
140-190/508 |
| Subcellular location: |
Nucleus, Cytoplasm |
| Source: |
KLH conjugated synthetic peptide derived from human ABI1 |
| Gene ID number: |
10006 |
| Swiss Prot: |
Q8IZP0 |
| Tested applications: |
IF(IHC-P) |
| Recommended dilutions: |
IF(IHC-P)(1:50-200) |
| Crossreactivity: |
Mouse, Rat, Human |
| Crossreactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Antigen background: |
EPS8 and SOS1 exhibits Rac specific guanine nucleotide exchange factor (GEF) activity and ABI1 seems to act as an adapter in the complex, In brain, In vitro, Involved in cytoskeletal reorganization and EGFR signaling, May play a role in regulation of EGF-induced Erk pathway activation, Recruits WASF1 to lamellipodia and there seems to regulate WASF1 protein level, Regulates ABL1/c-Abl-mediated phosphorylation of ENAH, Together with EPS8 participates in transduction of signals from Ras to Rac, a trimeric complex of ABI1, seems to regulate the dendritic outgrowth and branching as well as to determine the shape and number of synaptic contacts of developing neurons, May act in negative regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2 |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA |
| Excitation Emission: |
494nm/518nm |
| Synonyms: |
E3B1 ABI-1 |
| Properties: |
Bioss Primary Conjugated Antibodies FITC is highly sensitive to pH extremes, FITC has a green emission that's usually collected at 530 nanometers, FITC has a high quantum yield (efficiency of energy transfer from absorption to emission fluorescence) and approximately half of the absorbed photons are emitted as fluorescent light, For fluorescent microscopy applications, This Bioss Primary Conjugated Antibodies Fluorescein isothiocyanate (FITC) antibody is currently after some BD antibodies the most commonly used fluorescent dye for FACS, When excited at 488 nanometers, its photo bleaching effects are not observed due to a very brief interaction at the laser intercept, the 1 FITC is seldom used as it photo bleaches rather quickly though in flow cytometry applications, the FL1 detector of a FACSCalibur or FACScan, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
ABI1 Conjugated |
| Short name: |
FITC Conjugated, ABI1 Antibody |
| Technique: |
Fluorescein, antibodies against human proteins, antibodies for, antibody Conjugates, Antibody |
| Label: |
FITC |
| Alternative name: |
fluorecein coupled, ABI1 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
11320 |
| Gene: |
ABI1 |
More about : ABI1 |
| Long gene name: |
abl interactor 1 |
| Synonyms gene: |
SSH3BP1 |
| Synonyms gene name: |
spectrin SH3 domain binding protein 1 abl-interactor 1 |
| Locus: |
10p12, 1 |
| Discovery year: |
1999-05-17 |
| GenBank acession: |
U87166 |
| Entrez gene record: |
10006 |
| Pubmed identfication: |
9593709 9010225 |
| RefSeq identity: |
NM_005470 |
| Havana BLAST/BLAT: |
OTTHUMG00000017848 |